Protection of injured retinal ganglion cell dendrites and unfolded protein response resolution after long-term dietary resveratrol.


:Long-term dietary supplementation with resveratrol protects against cardiovascular disease, osteoporesis, and metabolic decline. This study determined how long-term dietary resveratrol treatment protects against retinal ganglion cell (RGC) dendrite loss after optic nerve injury and alters the resolution of the unfolded protein response. Associated changes in markers of endoplasmic reticulum stress in RGCs also were investigated. Young-adult Thy1-yellow fluorescent protein (YFP) and C57BL/6 mice received either control diet or diet containing resveratrol for approximately 1 year. Both groups then received optic nerve crush (ONC). Fluorescent RGC dendrites in the Thy1-YFP mice were imaged weekly for 4 weeks after ONC. There was progressive loss of dendrite length in all RGC types within the mice that received control diet. Resveratrol delayed loss of dendrite complexity and complete dendrite loss for most RGC types. However, there were variations in the rate of retraction among different RGC types. Three weeks after ONC, cytoplasmic binding immunoglobulin protein (BiP) suppression observed in control diet ganglion cell layer neurons was reversed in mice that received resveratrol, nuclear C/EBP homologous protein (CHOP) was near baseline in control diet eyes but was moderately increased by resveratrol; and increased nuclear X-box-binding protein-1 (XBP-1) observed in control diet eyes was reduced in eyes that received resveratrol to the same level as in control diet uncrushed eyes. These results indicate that protection of dendrites by resveratrol after ONC differs among RGC types and suggest that alterations in long-term expression of binding immunoglobulin protein, CHOP, and XBP-1 may contribute to the resveratrol-mediated protection of RGC dendrites after ONC.


Neurobiol Aging


Neurobiology of aging


Lindsey JD,Duong-Polk KX,Hammond D,Leung CK,Weinreb RN




Has Abstract


2015-05-01 00:00:00














  • Brain atrophy associated with baseline and longitudinal measures of cognition.

    abstract::The overall goal was to identify patterns of brain atrophy associated with cognitive impairment and future cognitive decline in non-demented elders. Seventy-one participants were studied with structural MRI and neuropsychological testing at baseline and 1-year follow-up. Deformation-based morphometry was used to exami...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cardenas VA,Chao LL,Studholme C,Yaffe K,Miller BL,Madison C,Buckley ST,Mungas D,Schuff N,Weiner MW

    更新日期:2011-04-01 00:00:00

  • LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation.

    abstract::Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Marras C,Klein C,Lang AE,Wakutani Y,Moreno D,Sato C,Yip E,Munhoz RP,Lohmann K,Djarmati A,Bi A,Rogaeva E

    更新日期:2010-04-01 00:00:00

  • Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation.

    abstract::The brain mechanisms underlying the effect of intellectual enrichment may evolve along the normal aging Alzheimer's disease (AD) cognitive spectrum and may include both protective and compensatory mechanisms. We assessed the association between early intellectual enrichment (education, years) and average cortical flor...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Arenaza-Urquijo EM,Bejanin A,Gonneaud J,Wirth M,La Joie R,Mutlu J,Gaubert M,Landeau B,de la Sayette V,Eustache F,Chételat G

    更新日期:2017-11-01 00:00:00

  • Suggested guidelines for the housing and husbandry of rodents for aging studies.

    abstract::The available published guidelines for the housing of rodents are reviewed, and assessments are made with regard to whether the data on which these guidelines are based appear to be sound. Ambient air temperature, relative humidity, lighting levels and photoperiods, sound levels, cage sizes, and ventilation rates are ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Clough G

    更新日期:1991-11-01 00:00:00

  • Age-related defects in lifespan and learning ability in SAMP8 mice.

    abstract::Pertinent animal models of age-related learning deficiencies are required to elucidate the mechanism of age-related learning deficiencies and to develop novel therapeutic drugs for age-related diseases such as learning defects. Among many strains of accelerated senescence prone, senescence-accelerated mouse (SAM), SAM...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Nomura Y,Okuma Y

    更新日期:1999-03-01 00:00:00

  • White matter loss in healthy ageing: a postmortem analysis.

    abstract::Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

    更新日期:2009-08-01 00:00:00

  • Sleep apnea and nocturnal myoclonus in the elderly.

    abstract::Insomnia, daytime sleepiness, and nocturnal wandering, so common in the elderly, are caused largely by two specific pathophysiologic processes. Sleep apnea is a condition where respiration pauses during sleep, leading to arousal. Sleep apnea is due either to obstruction in the throat or failure of the central respirat...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Kripke DF,Ancoli-Israel S,Okudaira N

    更新日期:1982-01-01 00:00:00

  • Inter-age variability of bona fide unvaried transcripts Normalization of quantitative PCR data in ischemic stroke.

    abstract:BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

    更新日期:2010-04-01 00:00:00

  • CSF pro-orexin and amyloid-β38 expression in Alzheimer's disease and frontotemporal dementia.

    abstract::There is an unmet need for markers that can stratify different forms and subtypes of dementia. Because of similarities in clinical presentation, it can be difficult to distinguish between Alzheimer's disease (AD) and frontotemporal dementia (FTD). Using a multiplex targeted proteomic LC-MS/MS platform, we aimed to ide...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Heywood WE,Hallqvist J,Heslegrave AJ,Zetterberg H,Fenoglio C,Scarpini E,Rohrer JD,Galimberti D,Mills K

    更新日期:2018-12-01 00:00:00

  • Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial.

    abstract::This study evaluated the effect of the alpha-2A-adrenoceptor agonist guanfacine on prefrontally mediated cognitive functions, as well as quality of life and global function in healthy older participants. One hundred twenty-three participants aged 75 years and older were randomly assigned to guanfacine 0.5 mg, 0.1 mg, ...

    journal_title:Neurobiology of aging

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Barcelos NM,Van Ness PH,Wagner AF,MacAvoy MG,Mecca AP,Anderson GM,Trentalange M,Hawkins KA,Sano M,Arnsten AFT,van Dyck CH

    更新日期:2018-10-01 00:00:00

  • JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1.

    abstract::The activity of beta-secretase (BACE1), the endo-protease essential for the production of amyloid beta (Abeta) peptides, is increased in brain of late-onset sporadic Alzheimer's disease (AD), and oxidative stress is the potential cause of this event. Oxidative stress up-regulates the expression and the activity of BAC...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Tamagno E,Guglielmotto M,Giliberto L,Vitali A,Borghi R,Autelli R,Danni O,Tabaton M

    更新日期:2009-10-01 00:00:00

  • Effect of aging on cerebral A1 adenosine receptors: A [18F]CPFPX PET study in humans.

    abstract::Cerebral A(1) adenosine receptors (A(1)AR) fulfill important neuromodulatory and homeostatic functions. The present study examines possible age-related A(1)AR changes in living humans by positron emission tomography (PET) and the A(1)AR ligand [(18)F]CPFPX. Thirty-six healthy volunteers aged 22-74 years were included....

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Meyer PT,Elmenhorst D,Boy C,Winz O,Matusch A,Zilles K,Bauer A

    更新日期:2007-12-01 00:00:00

  • Structural complexity is negatively associated with brain activity: a novel multimodal test of compensation theories of aging.

    abstract::Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atrophy causes a compensatory neural response in the form of increased brai...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: McDonough IM,Madan CR

    更新日期:2020-11-14 00:00:00

  • Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

    abstract::Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

    更新日期:2015-01-01 00:00:00

  • Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function.

    abstract::Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

    更新日期:2010-01-01 00:00:00

  • Everyday memory deficits in very mild Alzheimer's disease.

    abstract::Memory complaints of patients sometimes are not verified via standard cognitive testing. Acquisition of information in everyday life requires memorization in complex three-dimensional environments. The authors mimicked this with a photorealistic virtual environment (VE). Memory for verbal material and spatial scenery ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Widmann CN,Beinhoff U,Riepe MW

    更新日期:2012-02-01 00:00:00

  • Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.

    abstract::Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

    更新日期:2016-06-01 00:00:00

  • Growth hormone response to apomorphine, a dopamine receptor agonist, in normal aging and in dementia of the Alzheimer type.

    abstract::The growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg SC) was studied in young and elderly normal subjects as well as in patients with dementia of the Alzheimer type (DAT) and controls matched for age, gender and Quetelet index. The GH response was significantly decrease...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章,评审


    authors: Lal S,Nair NP,Thavundayil JX,Tawar V,Tesfaye Y,Dastoor D,Gauthier S,Guyda H

    更新日期:1989-05-01 00:00:00

  • Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea.

    abstract::Oxidative stress is considered to be a major contributor to age-related hearing loss (ARHL). Here, we investigated whether pomegranate peel extract (PPE) protected against hearing loss by decreased oxidative stress in the cochlea of D-galactose-induced accelerated aging mice. The aging mice exhibited an increase in he...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Liu S,Xu T,Wu X,Lin Y,Bao D,Di Y,Ma T,Dang Y,Jia P,Xian J,Wang A,Liu Y

    更新日期:2017-11-01 00:00:00

  • Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease.

    abstract::It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

    更新日期:2015-01-01 00:00:00

  • Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model.

    abstract::Deficits in synaptic structure and function are likely to underlie cognitive impairments in Alzheimer's disease. While synaptic deficits are commonly found in animal models of amyloidosis, it is unclear how amyloid pathology may impair synaptic functions. In some amyloid mouse models of Alzheimer's disease, however, s...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cavanagh C,Tse YC,Nguyen HB,Krantic S,Breitner JC,Quirion R,Wong TP

    更新日期:2016-11-01 00:00:00

  • A reliable MR measurement of medial temporal lobe width from the Sunnybrook Dementia Study.

    abstract::We studied the hippocampal angle and spatial relationships of medial temporal lobe (MTL) structures, using midbrain colliculi and inter-collicular sulcus (ICS) as landmarks, and measured MTL width on axial 3D-T1-weighted MRI at ICS level in 41 normal, aged participants. Mean hippocampal angle was 29 degrees (range 17-...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gao FQ,Black SE,Leibovitch FS,Callen DJ,Lobaugh NJ,Szalai JP

    更新日期:2003-01-01 00:00:00

  • Genetic association of low density lipoprotein receptor and Alzheimer's disease.

    abstract::The low density lipoprotein receptor (LDLR) is an attractive candidate gene for genetic association with Alzheimer's disease (AD) because: (i) the LDLR is an apolipoprotein E (apoE) receptor, alleles of which have been associated with AD, (ii) LDLR resides at chromosome 19p13.3 within a region linked to AD, and (iii) ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gopalraj RK,Zhu H,Kelly JF,Mendiondo M,Pulliam JF,Bennett DA,Estus S

    更新日期:2005-01-01 00:00:00

  • Intrafamilial variable phenotype including corticobasal syndrome in a family with p.P301L mutation in the MAPT gene: first report in South America.

    abstract::Frontotemporal lobar degeneration is a neuropathological disorder that causes a variety of clinical syndromes including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal syndrome (CBS). FTD associated with parkinsonism occurs frequently as a result of mutations in the C9orf72 gene and als...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Gatto EM,Allegri RF,Da Prat G,Chrem Mendez P,Hanna DS,Dorschner MO,Surace EI,Zabetian CP,Mata IF

    更新日期:2017-05-01 00:00:00

  • The transcription factor PITX3 is associated with sporadic Parkinson's disease.

    abstract::Parkinson's disease (PD) is a progressive neurodegenerative disease with typical motor symptoms due to the preferential loss of midbrain dopaminergic (mDA) neurons in the Substantia nigra pars compacta. Several proteins of the homeodomain family are crucial for the development of mDA neurons. These proteins remain exp...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Fuchs J,Mueller JC,Lichtner P,Schulte C,Munz M,Berg D,Wüllner U,Illig T,Sharma M,Gasser T

    更新日期:2009-05-01 00:00:00

  • Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT.

    abstract::This study aimed to investigate cross-sectional and longitudinal changes of regional cerebral blood flow (rCBF) in preclinical dementia using single photon emission computed tomography (SPECT). SPECT and cognitive function were investigated in 39 mild cognitive impairment (MCI) subjects and 20 age-matched controls. Al...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Huang C,Eidelberg D,Habeck C,Moeller J,Svensson L,Tarabula T,Julin P

    更新日期:2007-07-01 00:00:00

  • Intermale aggression and infanticide in aged C57BL/6J male mice: behavioral deficits are not related to serum testosterone (T) levels and are not recovered by supplemental T.

    abstract::Healthy aged adult (24-26 months of age) and young adult (2-4 months of age) c57BL/6J male mice were assessed for intermale aggression, pup-killing behavior (infanticide), and circulating levels of testosterone (T). When compared to young adult male mice, aged adult males were highly variable in the exhibition of both...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Svare B,Mann M,Broida J,Kinsley C,Ghiraldi L,Miele J,Konen C

    更新日期:1983-01-01 00:00:00

  • Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.

    abstract::There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Whittington RA,Virág L,Gratuze M,Petry FR,Noël A,Poitras I,Truchetti G,Marcouiller F,Papon MA,El Khoury N,Wong K,Bretteville A,Morin F,Planel E

    更新日期:2015-08-01 00:00:00

  • Feed efficiency, food choice, and food reward behaviors in young and old Fischer rats.

    abstract::Increased susceptibility to energy imbalance and anorexia in old age are risk factors for malnutrition during aging, but the underlying mechanisms are not well understood. Here, we explored changes in taste-guided hedonic value ("liking") and motivation to obtain ("wanting") palatable foods as potential mediators of a...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Frutos MG,Pistell PJ,Ingram DK,Berthoud HR

    更新日期:2012-01-01 00:00:00

  • Age-related learning and memory deficits in odor-reward association in rats.

    abstract::In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Roman FS,Alescio-Lautier B,Soumireu-Mourat B

    更新日期:1996-01-01 00:00:00