Abstract：
:Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for physical enrichment in all groups. In this study, rats were socially housed or nonsocially housed throughout their lifespan and tested in the radial arm maze to measure working memory (WM) and reference memory longitudinally at 3 ages. In old age, exclusively, socially housed rats made significantly less WM errors than nonsocially housed rats, while reference memory errors did not differ between groups at any age. Anxiety, as assessed behaviorally and physiologically, could not account for the observed differences in WM. These data provide the first evidence that social enrichment alone can prevent age-related WM deficits in spite of the effects of practice seen in longitudinal designs. Importantly, our model will facilitate future investigations into the mechanisms underlying the neuroprotective benefits of sociability in old age.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Templer VL,Wise TB,Heimer-McGinn VRdoi
10.1016/j.neurobiolaging.2018.11.016subject
Has Abstractpub_date
2019-03-01 00:00:00pages
117-125eissn
0197-4580issn
1558-1497pii
S0197-4580(18)30418-4journal_volume
75pub_type
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2011.10.024
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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