Social housing protects against age-related working memory decline independently of physical enrichment in rats.


:Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for physical enrichment in all groups. In this study, rats were socially housed or nonsocially housed throughout their lifespan and tested in the radial arm maze to measure working memory (WM) and reference memory longitudinally at 3 ages. In old age, exclusively, socially housed rats made significantly less WM errors than nonsocially housed rats, while reference memory errors did not differ between groups at any age. Anxiety, as assessed behaviorally and physiologically, could not account for the observed differences in WM. These data provide the first evidence that social enrichment alone can prevent age-related WM deficits in spite of the effects of practice seen in longitudinal designs. Importantly, our model will facilitate future investigations into the mechanisms underlying the neuroprotective benefits of sociability in old age.


Neurobiol Aging


Neurobiology of aging


Templer VL,Wise TB,Heimer-McGinn VR




Has Abstract


2019-03-01 00:00:00












  • Age-related changes in theta frequency stimulation-induced long-term potentiation.

    abstract::Several signaling mechanisms that are crucial for the induction of long-term potentiation (LTP) by theta frequency (5 Hz) trains of synaptic stimulation are altered in aged animals. To determine whether theta frequency stimulation-induced LTP is particularly sensitive to changes in synaptic function that occur in aged...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Watabe AM,O'Dell TJ

    更新日期:2003-03-01 00:00:00

  • Early exposure to ethanol or red wine and long-lasting effects in aged mice. A study on nerve growth factor, brain-derived neurotrophic factor, hepatocyte growth factor, and vascular endothelial growth factor.

    abstract::Prenatal ethanol exposure produces severe changes in brain, liver, and kidney through mechanisms involving growth factors. These molecules regulate survival, differentiation, maintenance, and connectivity of brain, liver, and kidney cells. Despite the abundant available data on the short and mid-lasting effects of eth...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ceccanti M,Mancinelli R,Tirassa P,Laviola G,Rossi S,Romeo M,Fiore M

    更新日期:2012-02-01 00:00:00

  • Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies.

    abstract::Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We invest...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Nedelska Z,Ferman TJ,Boeve BF,Przybelski SA,Lesnick TG,Murray ME,Gunter JL,Senjem ML,Vemuri P,Smith GE,Geda YE,Graff-Radford J,Knopman DS,Petersen RC,Parisi JE,Dickson DW,Jack CR Jr,Kantarci K

    更新日期:2015-01-01 00:00:00

  • N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice.

    abstract::Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity was localized to the N-terminal res...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Ou-Yang MH,Xu F,Liao MC,Davis J,Robinson JK,Van Nostrand WE

    更新日期:2015-02-01 00:00:00

  • Impact of chronic Helicobacter pylori infection on Alzheimer's disease: preliminary results.

    abstract::Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

    更新日期:2012-05-01 00:00:00

  • Insulin-like growth factor 2 rescues aging-related memory loss in rats.

    abstract::Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Steinmetz AB,Johnson SA,Iannitelli DE,Pollonini G,Alberini CM

    更新日期:2016-08-01 00:00:00

  • The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats.

    abstract::Pituitary-adrenal responsiveness to stress induced by either psychological (novelty) or physiological (ether) stimuli was examined in young (3 to 6 months) and old (24 to 27 months) male and female rats. In Experiment 1, subjects were placed in a novel environment for 3 min. Blood samples were collected at 0, 15, 30, ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Brett LP,Chong GS,Coyle S,Levine S

    更新日期:1983-07-01 00:00:00

  • Opposite patterns of age-associated changes in neurons and glial cells of the thalamus of human brain.

    abstract::In an autopsy series of 19 individuals, age-ranged 24-94, a relatively age-spared region, the anterior-ventral thalamus, was analyzed by immunohistochemical techniques to visualize neurons (neurofilament protein), astrocytes (glial fibrillary acidic protein), microglial cells (CD68) and amyloid precursor protein. The ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Guidolin D,Zunarelli E,Genedani S,Trentini GP,De Gaetani C,Fuxe K,Benegiamo C,Agnati LF

    更新日期:2008-06-01 00:00:00

  • Region-specific downregulation of free intracellular calcium in the aged rat brain.

    abstract::Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Hartmann H,Velbinger K,Eckert A,Müller WE

    更新日期:1996-07-01 00:00:00

  • Premorbid effects of APOE on synaptic proteins in human temporal neocortex.

    abstract::APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences synaptogenesis. We measured the concentration of two presynaptic proteins, synaptophysin and syntaxin 1, and also postsynaptic density-95 (PSD95), in superior temporal co...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Love S,Siew LK,Dawbarn D,Wilcock GK,Ben-Shlomo Y,Allen SJ

    更新日期:2006-06-01 00:00:00

  • Estradiol treatment improves biological rhythms in a preclinical rat model of menopause.

    abstract::The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Yin W,Borniger JC,Wang X,Maguire SM,Munselle ML,Bezner KS,Tesfamariam HM,Garcia AN,Hofmann HA,Nelson RJ,Gore AC

    更新日期:2019-11-01 00:00:00

  • Transcriptional profiling of Alzheimer blood mononuclear cells by microarray.

    abstract::We evaluated pathomechanisms and systemic manifestations of Alzheimer disease (AD), an aging-related dementing neurodegenerative disorder, by expression profiling. Blood mononuclear cell (BMC) transcriptomes of sporadic AD subjects and aged-matched normal elderly controls (NEC) were compared using the human NIA microa...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Maes OC,Xu S,Yu B,Chertkow HM,Wang E,Schipper HM

    更新日期:2007-12-01 00:00:00

  • Functional and structural aging of the speech sensorimotor neural system: functional magnetic resonance imaging evidence.

    abstract::The ability to perceive and produce speech undergoes important changes in late adulthood. The goal of the present study was to characterize functional and structural age-related differences in the cortical network that support speech perception and production, using magnetic resonance imaging, as well as the relations...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Tremblay P,Dick AS,Small SL

    更新日期:2013-08-01 00:00:00

  • Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation.

    abstract::Astrocytes and microglia from cerebral cortex of 3-, 6-, 12-, and 24-month-old F344 male rat donors showed progressively greater proliferation during primary culture. Microglia from aging donor brains exhibited an amoeboid-like morphology and express antigens characteristic of an activated state (e.g., major histocomp...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rozovsky I,Finch CE,Morgan TE

    更新日期:1998-01-01 00:00:00

  • White matter loss in healthy ageing: a postmortem analysis.

    abstract::Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

    更新日期:2009-08-01 00:00:00

  • Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

    abstract::Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments wi...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Nash KR,Lee DC,Hunt JB Jr,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D

    更新日期:2013-06-01 00:00:00

  • Immunologic and tissue culture approaches to the neurobiology of aging.

    abstract::The neurobiology of aging continues to attract scientists and techniques from the more fundamental disciplines, as witness the great strides now being made from molecular genetic approaches to Alzheimer's disease. The present report is a commentary on reviews of immune mechanisms and tissue culture methods applied to ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rogers J,Rovigatti U

    更新日期:1988-09-01 00:00:00

  • Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease.

    abstract::The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippo...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

    更新日期:2008-09-01 00:00:00

  • BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain.

    abstract::In the axon terminals of the locus coeruleus (LC) neurons, a high level of axonal branching was occurred in the middle-aged brain, and the increased branching was maintained in the aged brain. In the present study, we hypothesized that neurotrophic support is necessary for the morphological age-related changes seen in...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Matsunaga W,Shirokawa T,Isobe K

    更新日期:2004-03-01 00:00:00

  • The frequency of the C9orf72 expansion in a Brazilian population.

    abstract::G4C2 hexanucleotide repeat expansions in the C9orf72 gene seem to be the cause of numerous cases of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). In this study, we investigated the presence of the G4C2 repeat expansion in 463 Brazilian probands, of whom 404 had ALS/motor neuron disease and ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Cintra VP,Bonadia LC,Andrade HMT,de Albuquerque M,Eusébio MF,de Oliveira DS,Claudino R,Gonçalves MVM,Teixeira AL Jr,de Godoy Rousseff Prado L,de Souza LC,Dourado MET Jr,Oliveira ASB,Tumas V,França MC Jr,Marques W Jr

    更新日期:2018-06-01 00:00:00

  • Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.

    abstract::Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset lear...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Zhang T,Jiang X,Xu M,Wang H,Sang X,Qin M,Bao P,Wang R,Zhang C,Lu H,Li Y,Ren J,Chang HC,Yan J,Sun Q,Xu J

    更新日期:2018-12-01 00:00:00

  • Associations of carotid arterial compliance and white matter diffusion metrics during midlife: modulation by sex.

    abstract::Sex differences in cerebral white matter (WM) aging have been debated extensively over the past 2 decades without unequivocal resolution. We aimed to determine if the effects of age and arterial stiffness on WM microstructure differ between sexes. Artery elasticity via carotid artery compliance (CAC) and WM diffusion ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Pasha EP,Birdsill AC,Oleson S,Tanaka H,Haley AP

    更新日期:2018-06-01 00:00:00

  • Naltrexone reverses age-induced cognitive deficits in rats.

    abstract::We evaluated young (3-4 months) and aged (22-24 months) male Sprague-Dawley rats in an attentional set-shifting procedure that assessed reversal, intradimensional shift (IDS), and extradimensional shift (EDS) discrimination learning tasks within one test session. These aspects of discrimination learning are sensitive ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Rodefer JS,Nguyen TN

    更新日期:2008-02-01 00:00:00

  • Trajectories of imaging markers in brain aging: the Rotterdam Study.

    abstract::With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal bra...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Vinke EJ,de Groot M,Venkatraghavan V,Klein S,Niessen WJ,Ikram MA,Vernooij MW

    更新日期:2018-11-01 00:00:00

  • Early development of social deficits in APP and APP-PS1 mice.

    abstract::Mimicking relevant behavioral features of the human pathology is one of the most important challenges for animal models of neurological disorders including Alzheimer disease (AD). Indeed, the most popular genetic AD mouse lines bearing mutations of the amyloid precursor protein (APP) and presenilin 1 genes (PS1), ofte...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Pietropaolo S,Delage P,Lebreton F,Crusio WE,Cho YH

    更新日期:2012-05-01 00:00:00

  • Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease.

    abstract::Posterior cingulate cortex (PCC) accumulates amyloid-β (Aβ) early in Alzheimer's disease (AD). The relative concentrations of full-length Aβ and truncated, pyroglutamate-modified Aβ (NpE3) forms, and their correlations to cognitive dysfunction in AD, are unknown. We quantified AβNpE3-42, AβNpE3-40, Aβ1-42, and Aβ1-40 ...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Pivtoraiko VN,Abrahamson EE,Leurgans SE,DeKosky ST,Mufson EJ,Ikonomovic MD

    更新日期:2015-01-01 00:00:00

  • Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory.

    abstract::The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 3...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Wolpe N,Ingram JN,Tsvetanov KA,Henson RN,Wolpert DM,Cam-CAN.,Rowe JB

    更新日期:2020-06-01 00:00:00

  • Cardiorespiratory fitness is associated with atrophy in Alzheimer's and aging over 2 years.

    abstract::We sought to describe change in cardiorespiratory (CR) fitness over 2 years in those with early-stage Alzheimer's disease (AD) and nondemented aging and assess the relationship of CR fitness with cognitive decline, brain atrophy, and dementia progression. Individuals with early-stage AD (n = 37) and without dementia (...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Vidoni ED,Honea RA,Billinger SA,Swerdlow RH,Burns JM

    更新日期:2012-08-01 00:00:00

  • The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.

    abstract::There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease. We measured the concentrations of h...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Selley ML,Close DR,Stern SE

    更新日期:2002-05-01 00:00:00

  • Rare structural genetic variation in human prion diseases.

    abstract::Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutz...

    journal_title:Neurobiology of aging

    pub_type: 杂志文章


    authors: Lukic A,Uphill J,Brown CA,Beck J,Poulter M,Campbell T,Adamson G,Hummerich H,Whitfield J,Ponto C,Zerr I,Lloyd SE,Collinge J,Mead S

    更新日期:2015-05-01 00:00:00