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Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo.

Abstract：

:Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neurotoxicity induced by the injection of a lentiviral vector encoding a short N-terminal fragment of mutant Huntingtin (mHtt) into the mouse striatum. Neither constitutive Capucin deficiency in knockout mice nor lentiviral vector-mediated Capucin overexpression in the striatum of adult wild type mice significantly modified vulnerability to the mHtt fragment in vivo, suggesting that Capucin has no impact on mHtt toxicity.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Galvan L,Lepejová N,Gaillard MC,Malgorn C,Guillermier M,Houitte D,Bonvento G,Petit F,Dufour N,Héry P,Gérard M,Elalouf JM,Déglon N,Brouillet E,de Chaldée M

doi

10.1016/j.neurobiolaging.2012.01.009

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

1845.e5-6

issue

8

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(12)00025-5

journal_volume

33

pub_type

杂志文章

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