The levels of cerebrospinal fluid Abeta40 and Abeta42(43) are regulated age-dependently.

abstract：:Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia. However, limited information is available on the effect of age, the major risk factor of AD, on Reelin expression. Here, ...

journal_title：Neurobiology of aging

authors： Knuesel I,Nyffeler M,Mormède C,Muhia M,Meyer U,Pietropaolo S,Yee BK,Pryce CR,LaFerla FM,Marighetto A,Feldon J

更新日期：2009-05-01 00:00:00

abstract：:In Pick disease and progressive supranuclear palsy (PSP), accumulations of phosphorylated tau are associated with oxidative stress, although the mechanism linking these features remains unknown. However, we suspected that the oxidative stress-induced activation of mitogen-activated protein kinases might lead to tau ph...

journal_title：Neurobiology of aging

authors： Hartzler AW,Zhu X,Siedlak SL,Castellani RJ,Avilá J,Perry G,Smith MA

更新日期：2002-09-01 00:00:00

abstract：:The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer's disease, the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with the right hippocampus volume. Here,...

journal_title：Neurobiology of aging

authors： Teipel SJ,Grothe MJ,Wittfeld K,Hoffmann W,Hegenscheid K,Völzke H,Homuth G,Grabe HJ

更新日期：2015-06-01 00:00:00

abstract：:Iron overload may contribute to the risk of Alzheimer's disease (AD). In the Epistasis Project, with 1757 cases of AD and 6295 controls, we studied 4 variants in 2 genes of iron metabolism: hemochromatosis (HFE) C282Y and H63D, and transferrin (TF) C2 and -2G/A. We replicated the reported interaction between HFE 282Y ...

journal_title：Neurobiology of aging

authors： Lehmann DJ,Schuur M,Warden DR,Hammond N,Belbin O,Kölsch H,Lehmann MG,Wilcock GK,Brown K,Kehoe PG,Morris CM,Barker R,Coto E,Alvarez V,Deloukas P,Mateo I,Gwilliam R,Combarros O,Arias-Vásquez A,Aulchenko YS,Ikram MA

更新日期：2012-01-01 00:00:00

abstract：:Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detriti...

journal_title：Neurobiology of aging

authors： Rogers J,Webster S,Lue LF,Brachova L,Civin WH,Emmerling M,Shivers B,Walker D,McGeer P

更新日期：1996-09-01 00:00:00

abstract：:In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin tra...

journal_title：Neurobiology of aging

authors： Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

更新日期：2012-03-01 00:00:00

abstract：:Amnestic mild cognitive impairment (aMCI) is accompanied by the accelerated cognitive decline and rapid brain degeneration with aging. However, the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown. In this study, we constructed the brain structur...

journal_title：Neurobiology of aging

authors： Zhao T,Sheng C,Bi Q,Niu W,Shu N,Han Y

更新日期：2017-11-01 00:00:00

abstract：:Plasma membrane cellular prion protein (PrP(C)) is a high-affinity receptor for toxic soluble amyloid-β (Aβ) oligomers that mediates synaptic dysfunction. Secreted forms of PrP(C) resulting from PrP(C) α-cleavage (PrPN1) or shedding (shed PrP(C)) display neuroprotective activity in neuronal cultures and in mouse model...

journal_title：Neurobiology of aging

authors： Béland M,Bédard M,Tremblay G,Lavigne P,Roucou X

更新日期：2014-07-01 00:00:00

abstract：:A loss of hippocampal neurons and synapses had been considered a hallmark of normal aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent stereological studies in humans have shown that only a relatively minor neuron loss occurs with aging and that this loss is restricted to spe...

journal_title：Neurobiology of aging

authors： Calhoun ME,Kurth D,Phinney AL,Long JM,Hengemihle J,Mouton PR,Ingram DK,Jucker M

更新日期：1998-11-01 00:00:00

abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

journal_title：Neurobiology of aging

authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

更新日期：2012-04-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

journal_title：Neurobiology of aging

authors： Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

更新日期：2004-11-01 00:00:00

abstract：:Cross-sectional studies show that elevated cerebral amyloid is associated with greater white-matter hyperintensity (WMH) burden in cognitively normal (CN) older adults. However, the relative time courses of amyloid and WMH accrual are unclear. To address this, we tested the associations between known WMH correlates-ag...

journal_title：Neurobiology of aging

authors： Scott JA,Braskie MN,Tosun D,Maillard P,Thompson PM,Weiner M,DeCarli C,Carmichael OT,ADNI.

更新日期：2016-12-01 00:00:00

abstract：:Accumulating evidence suggests that engagement in leisure activities is associated with favorable trajectories of cognitive aging, but little is known about brain changes related to both activities and cognition. White matter microstructure shows experience-dependent plasticity and declines in aging. Therefore, we inv...

journal_title：Neurobiology of aging

authors： Köhncke Y,Laukka EJ,Brehmer Y,Kalpouzos G,Li TQ,Fratiglioni L,Bäckman L,Lövdén M

更新日期：2016-05-01 00:00:00

abstract：:To investigate whether dramatically waned dentate neurogenesis during aging is linked to diminution in neural stem/progenitor cell (NSC) number, we counted cells immunopositive for Sox-2 (a putative marker of NSCs) in the subgranular zone (SGZ) of young, middle-aged and aged F344 rats. The young SGZ comprised approxim...

journal_title：Neurobiology of aging

authors： Hattiangady B,Shetty AK

更新日期：2008-01-01 00:00:00

abstract：:The levels of tau phosphorylation differ between sexes in Alzheimer's disease (AD). Transcriptome-wide associations of sex by disease interaction could indicate whether specific genes underlie sex differences in tau pathology; however, no such study has been reported yet. We report the first analysis of the effect of ...

journal_title：Neurobiology of aging

authors： Cáceres A,González JR

更新日期：2020-12-01 00:00:00

abstract：:Using a dosing paradigm and an automated behavioral testing procedure designed to maximize potential drug efficacy, we evaluated the ability of clonidine to improve performance of aged monkeys on a trial-specific memory task. These results indicated that neither acutely administered (0.0025-0.04 mg/kg) or subchronical...

journal_title：Neurobiology of aging

authors： Bartus RT,Dean RL

更新日期：1988-07-01 00:00:00

abstract：:Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Severa...

journal_title：Neurobiology of aging

authors： Bullido MJ,Martínez-García A,Artiga MJ,Aldudo J,Sastre I,Gil P,Coria F,Muñoz DG,Hachinski V,Frank A,Valdivieso F

更新日期：2007-04-01 00:00:00

abstract：:We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fo...

journal_title：Neurobiology of aging

authors： Johnson SA,Rogers J,Finch CE

更新日期：1989-11-01 00:00:00

abstract：:The 3-dimensional (3-D) distribution of cholinergic neurons located throughout the extent of the entire basal forebrain of young (4-5 months old) and aged (24-25 months old) Fischer-344 rats was examined using choline acetyltransferase immunocytochemistry (ChAT-IR). The number and 3-D position of ChAT-IR neurons spann...

journal_title：Neurobiology of aging

authors： Smith ML,Deadwyler SA,Booze RM

更新日期：1993-07-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular basement membrane, and have been shown to be altered in patients with Alzheimer's Disease (AD). Although the HSPG agrin clearly orchestrates the differentiation of the neuromuscular junction, its role in the brain remains unclear. G...

journal_title：Neurobiology of aging

authors： Berzin TM,Zipser BD,Rafii MS,Kuo-Leblanc V,Yancopoulos GD,Glass DJ,Fallon JR,Stopa EG

更新日期：2000-03-01 00:00:00

abstract：:Flexible instrumental learning is required to harness the appropriate behaviors to obtain rewards and to avoid punishments. The precise contribution of dopaminergic midbrain regions (substantia nigra/ventral tegmental area [SN/VTA]) to this form of behavioral adaptation remains unclear. Normal aging is associated with...

journal_title：Neurobiology of aging

authors： Chowdhury R,Guitart-Masip M,Lambert C,Dolan RJ,Düzel E

更新日期：2013-10-01 00:00:00

abstract：:Fractal dimensionality (FD) measures the complexity within the folds and ridges of cortical and subcortical structures. We tested the degree that FD might provide a new perspective on the atrophy-compensation hypothesis: age or disease-related atrophy causes a compensatory neural response in the form of increased brai...

journal_title：Neurobiology of aging

authors： McDonough IM,Madan CR

更新日期：2020-11-14 00:00:00

abstract：:We studied the hippocampal angle and spatial relationships of medial temporal lobe (MTL) structures, using midbrain colliculi and inter-collicular sulcus (ICS) as landmarks, and measured MTL width on axial 3D-T1-weighted MRI at ICS level in 41 normal, aged participants. Mean hippocampal angle was 29 degrees (range 17-...

journal_title：Neurobiology of aging

authors： Gao FQ,Black SE,Leibovitch FS,Callen DJ,Lobaugh NJ,Szalai JP

更新日期：2003-01-01 00:00:00

abstract：:A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, ag...

journal_title：Neurobiology of aging

authors： Ibanez L,Dube U,Budde J,Black K,Medvedeva A,Davis AA,Perlmutter JS,Benitez BA,Cruchaga C

更新日期：2017-08-01 00:00:00

abstract：:A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET,...

journal_title：Neurobiology of aging

authors： Ross JP,Rayaprolu S,Bernales CQ,Soto-Ortolaza AI,van Gerpen J,Uitti RJ,Wszolek ZK,Rajput A,Rajput AH,Rajput ML,Ross OA,Vilariño-Güell C

更新日期：2014-04-01 00:00:00

abstract：:This study aims to evaluate the clinical validity of [18F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition...

journal_title：Neurobiology of aging

authors： Kang JM,Lee SY,Seo S,Jeong HJ,Woo SH,Lee H,Lee YB,Yeon BK,Shin DH,Park KH,Kang H,Okamura N,Furumoto S,Yanai K,Villemagne VL,Seong JK,Na DL,Ido T,Cho J,Lee KM,Noh Y

更新日期：2017-11-01 00:00:00

abstract：:G4C2 hexanucleotide repeat expansions in the C9orf72 gene seem to be the cause of numerous cases of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). In this study, we investigated the presence of the G4C2 repeat expansion in 463 Brazilian probands, of whom 404 had ALS/motor neuron disease and ...

journal_title：Neurobiology of aging

authors： Cintra VP,Bonadia LC,Andrade HMT,de Albuquerque M,Eusébio MF,de Oliveira DS,Claudino R,Gonçalves MVM,Teixeira AL Jr,de Godoy Rousseff Prado L,de Souza LC,Dourado MET Jr,Oliveira ASB,Tumas V,França MC Jr,Marques W Jr

更新日期：2018-06-01 00:00:00

abstract：:Aging increases the likelihood of cognitive decline after negative life events such as infection or injury. We have modeled this increased vulnerability in aged (24-month-old), but otherwise unimpaired F344xBN rats. In these animals, but not in younger (3-month-old) counterparts, a single intraperitoneal injection of ...

journal_title：Neurobiology of aging

authors： Chapman TR,Barrientos RM,Ahrendsen JT,Hoover JM,Maier SF,Patterson SL

更新日期：2012-04-01 00:00:00

abstract：:We recently reported that mutations in the valosin-containing protein (VCP) gene are a cause of 1%-2% of familial amyotrophic lateral sclerosis (ALS) cases, but their role in the pathogenesis of sporadic ALS is unclear. We undertook mutational screening of VCP in 701 sporadic ALS cases. Three pathogenic variants (p.Ar...

journal_title：Neurobiology of aging

authors： Abramzon Y,Johnson JO,Scholz SW,Taylor JP,Brunetti M,Calvo A,Mandrioli J,Benatar M,Mora G,Restagno G,Chiò A,Traynor BJ

更新日期：2012-09-01 00:00:00

abstract：:Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically...

journal_title：Neurobiology of aging

authors： Tan CH,Low KA,Chiarelli AM,Fletcher MA,Navarra R,Burzynska AZ,Kong TS,Zimmerman B,Maclin EL,Sutton BP,Gratton G,Fabiani M

更新日期：2019-12-01 00:00:00