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Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus.

Abstract：

:To investigate whether dramatically waned dentate neurogenesis during aging is linked to diminution in neural stem/progenitor cell (NSC) number, we counted cells immunopositive for Sox-2 (a putative marker of NSCs) in the subgranular zone (SGZ) of young, middle-aged and aged F344 rats. The young SGZ comprised approximately 50,000 Sox-2+ cells and this amount did not diminish with aging. Quantity of GFAP+ cells and vimentin+ radial glia also remained stable during aging in this region. Besides, in all age groups, analogous fractions of Sox-2+ cells expressed GFAP (astrocytes/NSCs), NG-2 (oligodendrocyte-progenitors/NSCs), vimentin (radial glia), S-100beta (astrocytes) and doublecortin (new neurons). Nevertheless, analyses of Sox-2+ cells with proliferative markers insinuated an increased quiescence of NSCs with aging. Moreover, the volume of rat-endothelial-cell-antigen-1+ capillaries (vascular-niches) within the SGZ exhibited an age-related decline, resulting in an increased expanse between NSCs and capillaries. Thus, decreased dentate neurogenesis during aging is not attributable to altered number or phenotype of NSCs. Instead, it appears to be an outcome of increased quiescence of NSCs due to changes in NSC milieu.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Hattiangady B,Shetty AK

doi

10.1016/j.neurobiolaging.2006.09.015

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

129-47

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(06)00340-X

journal_volume

29

pub_type

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