Investigation of C9orf72 repeat expansions in Parkinson's disease.

abstract：:Recent findings seem to converge towards a unified hypothesis trying to relate Down's syndrome (DS), trisomy 21 and Alzheimer's disease (AD). The majority of DS individuals develop neuropathological characteristics of AD by the age of 40. Previous cytogenetic studies performed by us showed an increased frequency of an...

journal_title：Neurobiology of aging

authors： Migliore L,Boni G,Bernardini R,Trippi F,Colognato R,Fontana I,Coppedè F,Sbrana I

更新日期：2006-05-01 00:00:00

abstract：:Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....

journal_title：Neurobiology of aging

authors： Steinmetz AB,Johnson SA,Iannitelli DE,Pollonini G,Alberini CM

更新日期：2016-08-01 00:00:00

abstract：:Distortions in the rest-activity rhythm in aging are commonly observed. Neurodegenerative changes of the suprachiasmatic nucleus have been proposed to underlie this disrupted rhythm. However, based on previous studies, it can be proposed that white matter hyperintensities (WMH) may also play a role in the altered rest...

journal_title：Neurobiology of aging

authors： Oosterman J,van Harten B,Vogels R,Gouw A,Weinstein H,Scheltens P,Scherder E

更新日期：2008-08-01 00:00:00

abstract：:Activated astrocytes have been identified as the main source of the serine protease inhibitor alpha 1-antichymotrypsin (ACT), an acute phase protein that is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. We analyzed the synthesis of ACT by cultured murine...

journal_title：Neurobiology of aging

authors： Kanemaru K,Meckelein B,Marshall DC,Sipe JD,Abraham CR

更新日期：1996-09-01 00:00:00

abstract：:Accumulating evidence indicates that white matter degeneration contributes to the neural disconnections that underlie Alzheimer's disease pathophysiology. Although this white matter degeneration is partly attributable to axonopathy associated with neuronal degeneration, amyloid β (Aβ) protein-mediated damage to oligod...

journal_title：Neurobiology of aging

authors： Horiuchi M,Maezawa I,Itoh A,Wakayama K,Jin LW,Itoh T,Decarli C

更新日期：2012-03-01 00:00:00

abstract：:Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but have yet to be thoroughly investigated in sIBM. A candidate gene analys...

journal_title：Neurobiology of aging

authors： Gang Q,Bettencourt C,Machado PM,Brady S,Holton JL,Pittman AM,Hughes D,Healy E,Parton M,Hilton-Jones D,Shieh PB,Needham M,Liang C,Zanoteli E,de Camargo LV,De Paepe B,De Bleecker J,Shaibani A,Ripolone M,Violano R,Mo

更新日期：2016-11-01 00:00:00

abstract：:Age-related changes in resting levels of the free intracellular calcium concentration ([Ca2+]i) as well as alterations of the rise in [Ca2+]i following depolarization have been investigated in acutely isolated brain cells of various regions of the rat brain. Characterization of the Ca2+ responses following KCl depolar...

journal_title：Neurobiology of aging

authors： Hartmann H,Velbinger K,Eckert A,Müller WE

更新日期：1996-07-01 00:00:00

abstract：:Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been foun...

journal_title：Neurobiology of aging

authors： Siitonen A,Nalls MA,Hernández D,Gibbs JR,Ding J,Ylikotila P,Edsall C,Singleton A,Majamaa K

更新日期：2017-05-01 00:00:00

abstract：:Elevated serum and cerebrospinal fluid concentrations of S100β, a protein predominantly found in glia, are associated with intracranial injury and neurodegeneration, although concentrations are also influenced by several other factors. The longitudinal association between serum S100β concentrations and brain health in...

journal_title：Neurobiology of aging

authors： Cox SR,Allerhand M,Ritchie SJ,Muñoz Maniega S,Valdés Hernández M,Harris SE,Dickie DA,Anblagan D,Aribisala BS,Morris Z,Sherwood R,Abbott NJ,Starr JM,Bastin ME,Wardlaw JM,Deary IJ

更新日期：2018-09-01 00:00:00

abstract：:Age-related changes in the interactive behavior of default mode network (DMN) with other resting state networks are poorly understood. We hypothesized that age would positively correlate with inter-network connectivity in late life and intellectual functioning was expected to moderate this relationship. The sample con...

journal_title：Neurobiology of aging

authors： Lindbergh CA,Zhao Y,Lv J,Mewborn CM,Puente AN,Terry DP,Renzi-Hammond LM,Hammond BR,Liu T,Miller LS

更新日期：2019-06-01 00:00:00

abstract：:Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were...

journal_title：Neurobiology of aging

authors： Davis S,Markowska AL,Wenk GL,Barnes CA

更新日期：1993-01-01 00:00:00

abstract：:Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent genetic factors contributing to Parkinson's disease (PD). The aim of our study was to explore LRRK2 variants in PD patients within the mainland Han Chinese population. The whole coding regions of LRRK2 from 296 PD patients were seque...

journal_title：Neurobiology of aging

authors： Zhang JR,Jin H,Li K,Mao CJ,Yang YP,Wang F,Gu CC,Zhang HJ,Chen J,Liu CF

更新日期：2018-12-01 00:00:00

abstract：:The low density lipoprotein receptor (LDLR) is an attractive candidate gene for genetic association with Alzheimer's disease (AD) because: (i) the LDLR is an apolipoprotein E (apoE) receptor, alleles of which have been associated with AD, (ii) LDLR resides at chromosome 19p13.3 within a region linked to AD, and (iii) ...

journal_title：Neurobiology of aging

authors： Gopalraj RK,Zhu H,Kelly JF,Mendiondo M,Pulliam JF,Bennett DA,Estus S

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects. METHODS:16 C, 6 CI, and 7 D subjects of comparable age w...

journal_title：Neurobiology of aging

authors： Cardenas VA,Du AT,Hardin D,Ezekiel F,Weber P,Jagust WJ,Chui HC,Schuff N,Weiner MW

更新日期：2003-07-01 00:00:00

abstract：:Age-related structural brain changes have been demonstrated repeatedly but data on the effect of gender on age-related structural brain changes are conflicting. Using high-resolution T1-weighted magnetic resonance imaging and voxel-based morphometry, we examined a population of 133 healthy adults (women, 73; men, 60; ...

journal_title：Neurobiology of aging

authors： Nunnemann S,Wohlschläger AM,Ilg R,Gaser C,Etgen T,Conrad B,Zimmer C,Mühlau M

更新日期：2009-01-01 00:00:00

abstract：:The associations of 4 proteins-AK4, ITPK1, HSPB2, and IGFBP5-with cognitive function in older adults were largely unexplained by known brain pathologies. We examined the extent to which individual protein associations with cognitive decline were attributable to microstructural changes in the brain. This study included...

journal_title：Neurobiology of aging

authors： Kim N,Yu L,Dawe R,Petyuk VA,Gaiteri C,De Jager PL,Schneider JA,Arfanakis K,Bennett DA

更新日期：2019-12-01 00:00:00

abstract：:In Pick disease and progressive supranuclear palsy (PSP), accumulations of phosphorylated tau are associated with oxidative stress, although the mechanism linking these features remains unknown. However, we suspected that the oxidative stress-induced activation of mitogen-activated protein kinases might lead to tau ph...

journal_title：Neurobiology of aging

authors： Hartzler AW,Zhu X,Siedlak SL,Castellani RJ,Avilá J,Perry G,Smith MA

更新日期：2002-09-01 00:00:00

abstract：:Vergence eye movements were recorded with the scleral search-coil system in 32 healthy subjects (ages 19-73 years) to characterize the age-related effects on the dynamic parameters of vergence responses to step (transient components) and ramp or sinusoidal targets (sustained components) under natural viewing condition...

journal_title：Neurobiology of aging

authors： Rambold H,Neumann G,Sander T,Helmchen C

更新日期：2006-01-01 00:00:00

abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

journal_title：Neurobiology of aging

authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

更新日期：2012-04-01 00:00:00

abstract：:Alteration of key regulatory kinases may cause aberrant protein phosphorylation and aggregation in Alzheimer's disease (AD) and Parkinson's disease (PD). In this study, we investigated expression and phosphorylation status of glycogen synthase kinase 3 (GSK-3), protein kinase B (Akt) and tau protein in peripheral bloo...

journal_title：Neurobiology of aging

authors： Armentero MT,Sinforiani E,Ghezzi C,Bazzini E,Levandis G,Ambrosi G,Zangaglia R,Pacchetti C,Cereda C,Cova E,Basso E,Celi D,Martignoni E,Nappi G,Blandini F

更新日期：2011-12-01 00:00:00

abstract：:Oxidative stress is believed to be a significant cause of Parkinson's disease (PD). DJ-1 is thought to be an oxidative sensor that protects cells from oxidative insult. It was reported that the level of total DJ-1 protein was significantly reduced in the substantia nigra of sporadic PD patients, suggesting that abnorm...

journal_title：Neurobiology of aging

authors： Xiong R,Wang Z,Zhao Z,Li H,Chen W,Zhang B,Wang L,Wu L,Li W,Ding J,Chen S

更新日期：2014-03-01 00:00:00

abstract：:Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like...

journal_title：Neurobiology of aging

authors： Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

更新日期：2016-06-01 00:00:00

abstract：:Here we report the relationship between age at onset, clinical course and genotype in a family with combined LRRK2 G2019S and Parkin exon 2 deletions. In the combined mutation carriers the age at onset and clinical course was highly variable and not always younger than in the carriers of LRRK2 G2019S mutations alone. ...

journal_title：Neurobiology of aging

authors： Marras C,Klein C,Lang AE,Wakutani Y,Moreno D,Sato C,Yip E,Munhoz RP,Lohmann K,Djarmati A,Bi A,Rogaeva E

更新日期：2010-04-01 00:00:00

abstract：:The present study was designed to examine the effects of the aging process on the response of motoneurons to axotomy. Accordingly, in aged cats using intracellular recording techniques, the electrophysiological properties of axotomized lumbar spinal cord motoneurons were compared with those of control (nonaxotomized) ...

journal_title：Neurobiology of aging

authors： Yamuy J,Englehardt JK,Morales FR,Chase MH

更新日期：1992-03-01 00:00:00

abstract：:Accumulation of disease-related proteins is a characteristic event observed in the pathogenesis of neurodegenerative diseases. β-secretase (BACE)-1, which initiates generation of β-amyloid (Aβ), is increased in the Alzheimer's diseased brain. However, the mechanisms of BACE1 accumulation in Alzheimer's disease are lar...

journal_title：Neurobiology of aging

authors： Yun SM,Cho SJ,Song JC,Song SY,Jo SA,Jo C,Yoon K,Tanzi RE,Choi EJ,Koh YH

更新日期：2013-03-01 00:00:00

abstract：:To investigate possible age-associated changes in human synaptic connectivity, superior-middle frontal cortex (Brodmann area 9) was evaluated with ultrastructural techniques. Short post mortem autopsy tissue was obtained from 37 cognitive normal individuals ranging in age from 20 to 89 years. A minimum of five subject...

journal_title：Neurobiology of aging

authors： Scheff SW,Price DA,Sparks DL

更新日期：2001-05-01 00:00:00

abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

journal_title：Neurobiology of aging

authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

更新日期：2008-12-01 00:00:00

abstract：:Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neuroto...

journal_title：Neurobiology of aging

authors： Galvan L,Lepejová N,Gaillard MC,Malgorn C,Guillermier M,Houitte D,Bonvento G,Petit F,Dufour N,Héry P,Gérard M,Elalouf JM,Déglon N,Brouillet E,de Chaldée M

更新日期：2012-08-01 00:00:00

abstract：:The density of D-1 and D-2 dopamine receptors in human caudate nucleus and putamen, obtained postmortem, were studied throughout the adult lifespan using [3H]fluphenazine as the dopamine receptor ligand. The D-1 subtype increased progressively with age in both regions, while the D-2 subtype declined in caudate nucleus...

journal_title：Neurobiology of aging

authors： Morgan DG,Marcusson JO,Nyberg P,Wester P,Winblad B,Gordon MN,Finch CE

更新日期：1987-05-01 00:00:00

abstract：:In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids inc...

journal_title：Neurobiology of aging

authors： Rinaldi P,Polidori MC,Metastasio A,Mariani E,Mattioli P,Cherubini A,Catani M,Cecchetti R,Senin U,Mecocci P

更新日期：2003-11-01 00:00:00