Abstract：
:The present study was designed to examine the effects of the aging process on the response of motoneurons to axotomy. Accordingly, in aged cats using intracellular recording techniques, the electrophysiological properties of axotomized lumbar spinal cord motoneurons were compared with those of control (nonaxotomized) motoneurons. In motoneurons that were subjected to axotomy, there was a reduction in axonal conduction velocity compared to that exhibited by control motoneurons. In addition, there were a number of changes in the configuration of the action potential following axotomy. The amplitude of the spike and the overshoot increased as did the slope of the soma-dendritic spike, whereas the delay between the initial segment and the soma-dendritic spikes decreased. The duration of the action potential's afterhyperpolarization increased; its amplitude remained unaffected although the calculated afterhyperpolarization current decreased. Following the spike, most of the axotomized motoneurons exhibited hyperpolarization undershoots and delayed depolarizations. Axotomized motoneurons exhibited a small decrease in the membrane potential and a reduction in the rheobasic current compared to control cells. The changes in the frequency distribution of axonal conduction velocity, afterhyperpolarization duration, afterhyperpolarization current and rheobase measurements suggest that aged motoneurons dedifferentiated following axotomy. These results indicate that axotomy, in aged motoneurons, results in the disruption of a variety of electrophysiological parameters and that the specific patterns of the responses that occur in axotomized motoneurons of adult cats also emerge in axotomized motoneurons of aged animals.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Yamuy J,Englehardt JK,Morales FR,Chase MHdoi
10.1016/0197-4580(92)90035-vsubject
Has Abstractpub_date
1992-03-01 00:00:00pages
231-8issue
2eissn
0197-4580issn
1558-1497pii
0197-4580(92)90035-Vjournal_volume
13pub_type
杂志文章abstract：:The growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg SC) was studied in young and elderly normal subjects as well as in patients with dementia of the Alzheimer type (DAT) and controls matched for age, gender and Quetelet index. The GH response was significantly decrease...
journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
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更新日期：1989-05-01 00:00:00
abstract：:Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition betwee...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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journal_title：Neurobiology of aging
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更新日期：2004-11-01 00:00:00
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journal_title：Neurobiology of aging
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abstract：:Here we employed human SHEP neuroblastoma cells either stably or inducibly expressing the amyloid precursor protein (APP) intracellular domain (AICD) to investigate its ability to modulate stress-induced cell death. Analysis of effector caspase activation revealed that AICD overexpression was specifically associated w...
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
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更新日期：1991-11-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章,meta分析,评审
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1996-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/0197-4580(95)97327-d
更新日期：1995-05-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2011-03-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/s0197-4580(01)00236-6
更新日期：2002-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2006.07.009
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journal_title：Neurobiology of aging
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1998-05-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：1983-07-01 00:00:00
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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abstract：:The complement system has been shown to have a critical pathogenetic role in amyotrophic lateral sclerosis (ALS). Recently a C7 variant in rs3792646 was linked to neurodegenerative diseases in a Chinese population. We used whole exome sequencing to evaluate the role of C7 (rs3792646) in ALS in a Chinese cohort with 19...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2020-11-13 00:00:00
abstract：:There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2015-08-01 00:00:00
