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Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.

Abstract：

:In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids including lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha- and beta-carotene) antioxidant micronutrients as well as activities of plasma and red blood cell (RBC) superoxide dismutase (SOD) and of plasma glutathione peroxidase (GPx) were measured in 25 patients with MCI, 63 AD patients and 53 controls. Peripheral levels and activities of antioxidants were similarly lower in MCI and AD patients as compared to controls. As MCI may represent a prodromal stage of AD, and oxidative damage appears to occur as one of the earliest pathophysiological events in AD, an increased intake of antioxidants in patients with MCI could be helpful in lowering the risk of conversion to dementia.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Rinaldi P,Polidori MC,Metastasio A,Mariani E,Mattioli P,Cherubini A,Catani M,Cecchetti R,Senin U,Mecocci P

doi

10.1016/s0197-4580(03)00031-9

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

915-9

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197458003000319

journal_volume

24

pub_type

临床试验,杂志文章

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