Age and species-dependent differences in the neurokinin B system in rat and human brain.

abstract：:Amyloid plaques are a characteristic feature in Alzheimer's disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Abeta1-30, which is homologous to Abeta, and allows plaque detection in vivo. microMRI was performed on AD model mice and controls prior to and following intracarotid injection with Gd-DTP...

journal_title：Neurobiology of aging

authors： Sigurdsson EM,Wadghiri YZ,Mosconi L,Blind JA,Knudsen E,Asuni A,Scholtzova H,Tsui WH,Li Y,Sadowski M,Turnbull DH,de Leon MJ,Wisniewski T

更新日期：2008-06-01 00:00:00

abstract：:Aged, cognitively-impaired rats (and humans) show hypothalamic-pituitary-adrenal (HPA) hyperactivity that correlates with hippocampal damage. The resultant increase in plasma glucocorticoid exposure is thought to contribute to impaired hippocampal function and to potentiate hippocampal neuron death. In young, adult ra...

journal_title：Neurobiology of aging

authors： Rowe W,Steverman A,Walker M,Sharma S,Barden N,Seckl JR,Meaney MJ

更新日期：1997-09-01 00:00:00

abstract：:We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of br...

journal_title：Neurobiology of aging

authors： Muller M,Appelman AP,van der Graaf Y,Vincken KL,Mali WP,Geerlings MI

更新日期：2011-05-01 00:00:00

abstract：:Low homocysteine levels and B vitamin treatment are reported to protect against declining cognitive health. Both B vitamins and homocysteine are involved in the production of S-adenosylmethionine, a universal methyl donor essential for the process of DNA methylation. We investigated the effect of a damaging coding var...

journal_title：Neurobiology of aging

authors： Flitton M,Rielly N,Warman R,Warden D,Smith AD,Macdonald IA,Knight HM

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD). METHODS:25 patients with mild FTD and 9 patients with mild SD as well as 15 healthy age-matched control subjects underwent 18F-FDG- positron emission tomography. Patient scans were compared w...

journal_title：Neurobiology of aging

authors： Diehl J,Grimmer T,Drzezga A,Riemenschneider M,Förstl H,Kurz A

更新日期：2004-09-01 00:00:00

abstract：:Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries. Recently, polymorphisms in the FTO gene of elderly subjects have also been linked to a reduced volume in the frontal lobe as well as increased risk for incident...

journal_title：Neurobiology of aging

authors： Benedict C,Jacobsson JA,Rönnemaa E,Sällman-Almén M,Brooks S,Schultes B,Fredriksson R,Lannfelt L,Kilander L,Schiöth HB

更新日期：2011-06-01 00:00:00

abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease have not yet been clarified, and it is not known whether there is a critical period. Estrogen induced significant protection against 6-hydroxydopamine-induced dopaminergic degeneration when administered immediately or 6 weeks, but not 20...

journal_title：Neurobiology of aging

authors： Rodriguez-Perez AI,Borrajo A,Valenzuela R,Lanciego JL,Labandeira-Garcia JL

更新日期：2015-02-01 00:00:00

abstract：:Oxidative stress is believed to be a significant cause of Parkinson's disease (PD). DJ-1 is thought to be an oxidative sensor that protects cells from oxidative insult. It was reported that the level of total DJ-1 protein was significantly reduced in the substantia nigra of sporadic PD patients, suggesting that abnorm...

journal_title：Neurobiology of aging

authors： Xiong R,Wang Z,Zhao Z,Li H,Chen W,Zhang B,Wang L,Wu L,Li W,Ding J,Chen S

更新日期：2014-03-01 00:00:00

abstract：:We designed this study to determine whether the sexual behavior of male monkeys changes on a diurnal schedule that coincides with changes in the levels of hormones such as luteinizing hormone (LH), testosterone, estradiol, and cortisol, and whether these differences vary with age. Old (n = 8) and young (n = 8) males w...

journal_title：Neurobiology of aging

authors： Chambers KC,Resko JA,Phoenix CH

更新日期：1982-04-01 00:00:00

abstract：:Support has recently been voiced for the genetic hypothesis of Alzheimer's disease; frequently at the expense of considerations of environmental factors. In the adult, genetic diseases rarely exist without modification by environment forces. Atherosclerosis leading to myocardial infarction may provide a useful model t...

journal_title：Neurobiology of aging

authors： Perl DP

更新日期：1989-09-01 00:00:00

abstract：:Parkinson's disease (PD) is a degenerative disorder of the nervous system and the cause of the majority of sporadic cases is unknown. Females are relatively protected from PD as compared with males and linkage studies suggested a PD susceptibility locus on the X chromosome. To determine a putative association of skewe...

journal_title：Neurobiology of aging

authors： Sharma A,Kaut O,Pavlova A,Fröhlich H,Ahmad A,Schmitt I,El-Maarri O,Oldenburg J,Wüllner U

更新日期：2017-09-01 00:00:00

abstract：:Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequen...

journal_title：Neurobiology of aging

authors： Tan EK,Lee J,Chen CP,Wong MC,Zhao Y

更新日期：2009-03-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, however, the effectiveness of this therapy is unclear because of the low statistical power and heterogeneity ...

journal_title：Neurobiology of aging

authors： Chou YH,Ton That V,Sundman M

更新日期：2020-02-01 00:00:00

abstract：:Time-dependent changes in brain activity were assessed in a group of older adults who maintained good physical and cognitive health at years 1, 3, 5, 7, and 9 of the Baltimore Longitudinal Study of Aging neuroimaging study. Each year, these participants underwent PET scans during rest and delayed verbal and figural re...

journal_title：Neurobiology of aging

authors： Beason-Held LL,Kraut MA,Resnick SM

更新日期：2008-04-01 00:00:00

abstract：:Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

journal_title：Neurobiology of aging

authors： Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

更新日期：2012-05-01 00:00:00

abstract：:We recently demonstrated that retinal ganglion cell function, optic nerve head parameters and the retinal nerve fiber layer thickness are not altered in early dementia of the Alzheimer type (DAT). Our current objective was to assess whether the function of cells located more distally in the retina is also unaffected b...

journal_title：Neurobiology of aging

authors： Justino L,Kergoat M,Bergman H,Chertkow H,Robillard A,Kergoat H

更新日期：2001-07-01 00:00:00

abstract：:The TgCRND8 mouse model of Alzheimer's disease exhibits progressive cortical and hippocampal β-amyloid accumulation, resulting in plaque pathology and spatial memory impairment by 3 months of age. We tested whether TgCRND8 cognitive function is disrupted prior to the appearance of macroscopic plaques in an object reco...

journal_title：Neurobiology of aging

authors： Francis BM,Kim J,Barakat ME,Fraenkl S,Yücel YH,Peng S,Michalski B,Fahnestock M,McLaurin J,Mount HT

更新日期：2012-03-01 00:00:00

abstract：:The reaction of lysine and arginine residues of proteins with 1,2-dicarbonyl compounds result in the formation of advanced glycation end products (AGEs). Accumulation of AGEs is a characteristic feature of the aging brain and contributes to the development of neurodegenerative diseases such as Alzheimer's disease (AD)...

journal_title：Neurobiology of aging

authors： Kuhla B,Boeck K,Schmidt A,Ogunlade V,Arendt T,Münch G,Lüth HJ

更新日期：2007-01-01 00:00:00

abstract：:This study evaluated the effect of the alpha-2A-adrenoceptor agonist guanfacine on prefrontally mediated cognitive functions, as well as quality of life and global function in healthy older participants. One hundred twenty-three participants aged 75 years and older were randomly assigned to guanfacine 0.5 mg, 0.1 mg, ...

journal_title：Neurobiology of aging

authors： Barcelos NM,Van Ness PH,Wagner AF,MacAvoy MG,Mecca AP,Anderson GM,Trentalange M,Hawkins KA,Sano M,Arnsten AFT,van Dyck CH

更新日期：2018-10-01 00:00:00

abstract：:Longitudinal human studies suggest that as we age, sociality provides protective benefits against cognitive decline. However, little is known about the underlying neural mechanisms. Rodent studies, which are ideal for studying cognition, fail to examine the independent effects of social housing while controlling for p...

journal_title：Neurobiology of aging

authors： Templer VL,Wise TB,Heimer-McGinn VR

更新日期：2019-03-01 00:00:00

abstract：:With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal bra...

journal_title：Neurobiology of aging

authors： Vinke EJ,de Groot M,Venkatraghavan V,Klein S,Niessen WJ,Ikram MA,Vernooij MW

更新日期：2018-11-01 00:00:00

abstract：:Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretat...

journal_title：Neurobiology of aging

authors： Roses AD

更新日期：1989-09-01 00:00:00

abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

journal_title：Neurobiology of aging

authors： Ohm TG,Busch C,Bohl J

更新日期：1997-07-01 00:00:00

abstract：:Delivery of drugs to specific sites in the CNS represents an essential therapeutic challenge. Extradural administration of opiates successfully delivers drugs to the CNS. The levodopa-carbidopa combination achieved some degree of site-specific delivery by pharmacological methods. Antibiotics have been administered thr...

journal_title：Neurobiology of aging

authors： Hollister LE

更新日期：1989-09-01 00:00:00

abstract：:The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, a...

journal_title：Neurobiology of aging

authors： Kalinin S,Willard SL,Shively CA,Kaplan JR,Register TC,Jorgensen MJ,Polak PE,Rubinstein I,Feinstein DL

更新日期：2013-10-01 00:00:00

abstract：:Prenatal ethanol exposure produces severe changes in brain, liver, and kidney through mechanisms involving growth factors. These molecules regulate survival, differentiation, maintenance, and connectivity of brain, liver, and kidney cells. Despite the abundant available data on the short and mid-lasting effects of eth...

journal_title：Neurobiology of aging

authors： Ceccanti M,Mancinelli R,Tirassa P,Laviola G,Rossi S,Romeo M,Fiore M

更新日期：2012-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a genetically complex disorder for which the definite diagnosis is only accomplished postmortem. Mutations in 3 genes (APP, PSEN1, and PSEN2) are known to cause AD, but a large number of familial cases do not harbor mutations in these genes and several unidentified genes that contain diseas...

journal_title：Neurobiology of aging

authors： Guerreiro RJ,Lohmann E,Kinsella E,Brás JM,Luu N,Gurunlian N,Dursun B,Bilgic B,Santana I,Hanagasi H,Gurvit H,Gibbs JR,Oliveira C,Emre M,Singleton A

更新日期：2012-05-01 00:00:00

abstract：:Decline in cognitive functions, including hippocampus-dependent spatial memory, is commonly observed at a later stage of aging (e.g., >20 months old in rodents) and typically studied after a discrete learning event. How normal aging, particularly at an early stage, affects the modulatory aspect of memory persistence i...

journal_title：Neurobiology of aging

authors： Gros A,Wang SH

更新日期：2018-07-01 00:00:00

abstract：:Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neuroto...

journal_title：Neurobiology of aging

authors： Galvan L,Lepejová N,Gaillard MC,Malgorn C,Guillermier M,Houitte D,Bonvento G,Petit F,Dufour N,Héry P,Gérard M,Elalouf JM,Déglon N,Brouillet E,de Chaldée M

更新日期：2012-08-01 00:00:00

abstract：:Prion diseases are a diverse group of neurodegenerative conditions, caused by the templated misfolding of prion protein. Aside from the strong genetic risk conferred by multiple variants of the prion protein gene (PRNP), several other variants have been suggested to confer risk in the most common type, sporadic Creutz...

journal_title：Neurobiology of aging

authors： Lukic A,Uphill J,Brown CA,Beck J,Poulter M,Campbell T,Adamson G,Hummerich H,Whitfield J,Ponto C,Zerr I,Lloyd SE,Collinge J,Mead S

更新日期：2015-05-01 00:00:00