The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease.

Abstract:

:In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons both in CJD and Alzheimer's disease (AD) as compared to controls. All these markers correlated (P < 0.001) with the severity of the neuropathological lesions. An increased IL-1beta concentration was found in AD and CJD CSF that correlated with the number of microglia and which did not change in the disease course of CJD.In conclusion, apoptotic neurons in CJD correlates to the neuropathological lesions and are probably related to the presence of inflammatory cells and cytokines which are present during the whole CJD disease process.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras P

doi

10.1016/s0197-4580(01)00236-6

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

59-64

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197458001002366

journal_volume

23

pub_type

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