Abstract:
:In order to investigate inflammation and apoptosis in Creutzfeldt-Jakob disease (CJD) patients, we analyzed astrocytes, microglia and apoptotic neurons in brain and IL-1beta in cerebrospinal fluid (CSF). Our results showed increased numbers of astrocytes in CJD and increased numbers of microglia and apoptotic neurons both in CJD and Alzheimer's disease (AD) as compared to controls. All these markers correlated (P < 0.001) with the severity of the neuropathological lesions. An increased IL-1beta concentration was found in AD and CJD CSF that correlated with the number of microglia and which did not change in the disease course of CJD.In conclusion, apoptotic neurons in CJD correlates to the neuropathological lesions and are probably related to the presence of inflammatory cells and cytokines which are present during the whole CJD disease process.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Van Everbroeck B,Dewulf E,Pals P,Lübke U,Martin JJ,Cras Pdoi
10.1016/s0197-4580(01)00236-6subject
Has Abstractpub_date
2002-01-01 00:00:00pages
59-64issue
1eissn
0197-4580issn
1558-1497pii
S0197458001002366journal_volume
23pub_type
杂志文章abstract::Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...
journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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