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On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease.

Abstract：

:A group of alterations in the structure of cortical microvessels is described in the brain tissue of neuropathologically confirmed patients with Alzheimer's disease. These changes include irregular thickening of the vessel walls, infiltration with amyloid and the serum P component of amyloid, loss of the perivascular neural plexus and the frequent occurrence of pits and lacunae in vessel walls. The possibility that these alterations may be related to blood brain barrier defects is suggested.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Scheibel AB,Duong T

doi

10.1016/s0197-4580(88)80014-9

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

41-2

issue

1

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(88)80014-9

journal_volume

9

pub_type

杂志文章

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