Abstract：
:Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or "cognitive phenotype" is variable. The apolipoprotein E ε4 (APOE ε4) allele has been associated with an amnestic presentation, but does not appear to fully explain the high prevalence of family history within this group. We examined polymorphisms in the genes ACE and IDE in relation to cognitive phenotype. In this study 276 participants with AD were categorized into 1 of 4 cognitive phenotype classifications: typical, amnestic, language, and posterior. Family history and possession of the APOE ε4 allele were most prevalent in the amnestic group. Of the 10 genetic variants of IDE, and the 3 genetic variants of ACE studied, only ACErs4291 and ACErs1800764 were nominally associated with the amnestic presentation.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Vardy ER,Brown K,Stopford CL,Thompson JC,Richardson AM,Neary D,Kalsheker N,Morgan K,Mann DM,Snowden JSdoi
10.1016/j.neurobiolaging.2010.11.003subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1486.e1-2issue
7eissn
0197-4580issn
1558-1497pii
S0197-4580(10)00484-7journal_volume
33pub_type
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pub_type： 杂志文章,评审
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更新日期：1992-09-01 00:00:00
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更新日期：1989-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of aging
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abstract：:Aging is accompanied by declines in memory performance, and particularly affects memories that rely on hippocampal-cortical systems, such as episodic and explicit. With aged populations significantly increasing, the need for preventing or rescuing memory deficits is pressing. However, effective treatments are lacking....
journal_title：Neurobiology of aging
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
abstract：:To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer's disease (AD). A purpose-buil...
journal_title：Neurobiology of aging
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journal_title：Neurobiology of aging
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abstract：:A study on familial Parkinson disease (PD) described 4 variants in the gene TMEM230 (Chr. 20p13) as the cause of PD. The aim of this study was to test if variants in the TMEM230 gene are associated with PD in 2 independent American European data sets. No variants in the TMEM230 region were found associated with PD, ag...
journal_title：Neurobiology of aging
pub_type： 杂志文章
doi：10.1016/j.neurobiolaging.2017.03.014
更新日期：2017-08-01 00:00:00
abstract：:This study aims to evaluate the clinical validity of [18F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition...
journal_title：Neurobiology of aging
pub_type： 杂志文章
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