Abstract:
:Dualistic effects of acetylcholine-esterase inhibitors on neuronal as well as vasoregulative function have been debated. This study investigated for the first time effects of medication on both components. Visually evoked potentials and resultant hemodynamic responses were assessed in Alzheimer patients (n=31) without vascular lesions in a MRI scan and compared to controls (n=20). After baseline recordings (AD0) tests were repeated under 2x1.5 to 2x3mg (AD1) and 2x4.5 to 2x6mg (AD2) rivastigmine/d. Long-term effects were investigated under 6 months of medication (AD2L). The ADAS, MMSE and DEMTECT were used to assess cognitive function at AD0, AD2 and AD2L. Improvement in vasoregulative function was independent from changes in evoked potentials. Acetylcholine-esterase inhibitors demonstrate substantial vascular effects in humans, which are independent from changes in neuronal function.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Rosengarten B,Paulsen S,Burr O,Kaps Mdoi
10.1016/j.neurobiolaging.2008.02.017subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1918-23issue
12eissn
0197-4580issn
1558-1497pii
S0197-4580(08)00066-3journal_volume
30pub_type
杂志文章abstract::Two neuroanatomically dissociable, large-scale cortical memory networks, referred to as the anterior and posterior medial temporal lobe (MTL) networks have recently been described in young adults using resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI)-based functional conne...
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