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A conservative viewpoint on linkage in Alzheimer's disease.

Abstract：

:Linkage data in Alzheimer's disease have not firmly established a genetic locus on chromosome 21 in early onset disease families. There is little or no support for a chromosome 21 locus in late onset families. Differences in the selection of families and the analysis of data accounts for the differences in interpretation. The actual location of a genetic locus (or loci) for Alzheimer's disease in the human genome will not be influenced by this controversy; more data from exclusion mapping and the use of several methods of linkage analysis will answer current questions.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Roses AD

doi

10.1016/0197-4580(89)90083-3

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

427-9; discussion 446-8

issue

5

eissn

0197-4580

issn

1558-1497

pii

0197-4580(89)90083-3

journal_volume

10

pub_type

杂志文章

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