Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

abstract：:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding paramet...

journal_title：Neurobiology of aging

authors： Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

更新日期：1990-07-01 00:00:00

abstract：:Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one ...

journal_title：Neurobiology of aging

authors： Mengel-From J,Christensen K,McGue M,Christiansen L

更新日期：2011-03-01 00:00:00

abstract：:The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzh...

journal_title：Neurobiology of aging

authors： Viaña JNM,Vickers JC,Cook MJ,Gilbert F

更新日期：2017-08-01 00:00:00

abstract：:The majority (90%-95%) of amyotrophic lateral sclerosis (ALS) is sporadic, and ∼50% of patients develop symptoms of frontotemporal degeneration (FTD) associated with shorter survival. The genetic polymorphism rs12608932 in UNC13A confers increased risk of sporadic ALS and sporadic FTD and modifies survival in ALS. Her...

journal_title：Neurobiology of aging

authors： Placek K,Baer GM,Elman L,McCluskey L,Hennessy L,Ferraro PM,Lee EB,Lee VMY,Trojanowski JQ,Van Deerlin VM,Grossman M,Irwin DJ,McMillan CT

更新日期：2019-01-01 00:00:00

abstract：:DNA methylation is an important regulatory mechanism of Parkinson's disease (PD). To investigate the relationship between DNA methylation and hydroxymethylation genes and PD, we performed gene-targeted sequencing using molecular inversion probes in a Chinese PD population. We sequenced 12 genes related to DNA methylat...

journal_title：Neurobiology of aging

authors： Shu L,Qin L,Min S,Pan H,Zhong J,Guo J,Sun Q,Yan X,Chen C,Tang B,Xu Q

更新日期：2019-12-01 00:00:00

abstract：:The visual processing of complex motion is impaired in Alzheimer's disease (AD). However, it is unclear whether these impairments are biased toward the motion stream or part of a general disruption of global visual processing, given some reports of impaired static form processing in AD. Here, for the first time, we di...

journal_title：Neurobiology of aging

authors： Porter G,Wattam-Bell J,Bayer A,Haworth J,Braddick O,Atkinson J,Tales A

更新日期：2017-08-01 00:00:00

abstract：:Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

journal_title：Neurobiology of aging

authors： Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

更新日期：2009-08-01 00:00:00

abstract：:Perisynaptic accumulations of amyloid β-protein (Aβ) play a critical role in the synaptic dysfunction underlying the cognitive impairment observed in Alzheimer's disease. The methionine residue at position 35 (Met35) in Aβ is highly subject to oxidation in Alzheimer's disease brains. In hippocampal brain slices we fou...

journal_title：Neurobiology of aging

authors： Ripoli C,Piacentini R,Riccardi E,Leone L,Li Puma DD,Bitan G,Grassi C

更新日期：2013-04-01 00:00:00

abstract：:This study aims to evaluate the clinical validity of [18F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition...

journal_title：Neurobiology of aging

authors： Kang JM,Lee SY,Seo S,Jeong HJ,Woo SH,Lee H,Lee YB,Yeon BK,Shin DH,Park KH,Kang H,Okamura N,Furumoto S,Yanai K,Villemagne VL,Seong JK,Na DL,Ido T,Cho J,Lee KM,Noh Y

更新日期：2017-11-01 00:00:00

abstract：:Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated ...

journal_title：Neurobiology of aging

authors： Lythgoe C,Perkes A,Peterson M,Schmutz C,Leary M,Ebbert MT,Ridge PG,Norton MC,Tschanz JT,Munger RG,Corcoran CD,Kauwe JS

更新日期：2015-01-01 00:00:00

abstract：:In the present study, the effects of long-term dietary restriction (60% of the calories in the ad lib diet, beginning at 16 weeks of age) on quantitative morphometric measures and histopathologic indications of aging have been investigated in the retina of Fischer 344 male rats. The animals were maintained by the NIA ...

journal_title：Neurobiology of aging

authors： O'Steen WK,Landfield PW

更新日期：1991-09-01 00:00:00

abstract：:Macrophages or activated microglia in the subretinal space are considered a hallmark of some retinal pathologies. We investigated the effects of age, pigmentation and CX(3)CR1 deficiency on the accumulation of macrophages/activated microglia in the outer retina of young and old Cx(3)cr1(gfp/gfp) (CX(3)CR1-deficient) o...

journal_title：Neurobiology of aging

authors： Chinnery HR,McLenachan S,Humphries T,Kezic JM,Chen X,Ruitenberg MJ,McMenamin PG

更新日期：2012-08-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution...

journal_title：Neurobiology of aging

authors： Sassi C,Nalls MA,Ridge PG,Gibbs JR,Ding J,Lupton MK,Troakes C,Lunnon K,Al-Sarraj S,Brown KS,Medway C,Clement N,Lord J,Turton J,Bras J,Almeida MR,ARUK Consortium.,Holstege H,Louwersheimer E,van der Flier WM,Schelte

更新日期：2016-10-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Regions of diffuse periventricular white matter hyperintensities (PVWMH) are a common finding on T(2)-weighted MRI scans of older subjects, but their aetiology remains unclear. The aim of this study was to characterize differences in water diffusion and magnetization transfer MRI parameters between macroscopically nor...

journal_title：Neurobiology of aging

authors： Bastin ME,Clayden JD,Pattie A,Gerrish IF,Wardlaw JM,Deary IJ

更新日期：2009-01-01 00:00:00

abstract：:Mutations in the presenilin genes account for the majority of familial Alzheimer disease (FAD) cases. In the present report we demonstrated that the FAD-linked presenilin 2 mutations (PS2 M239I and T122R) alter cystatin C trafficking in mouse primary neurons reducing secretion of its glycosylated form. These mutations...

journal_title：Neurobiology of aging

authors： Ghidoni R,Benussi L,Paterlini A,Missale C,Usardi A,Rossi R,Barbiero L,Spano P,Binetti G

更新日期：2007-03-01 00:00:00

abstract：:We previously established a single-neuron culture system to analyze the primary effects of neurotrophic factors and reported that NGF promoted neurite extension in young adult (4- to 6-month-old) rat dorsal root ganglion (DRG) neurons by promoting neurite arborization. In this study, we demonstrated that the effects o...

journal_title：Neurobiology of aging

authors： Itoh T,Sobue G,Yasuda T,Kimata K,Mitsuma T,Takahashi A

更新日期：1993-03-01 00:00:00

abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

journal_title：Neurobiology of aging

authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

更新日期：2003-01-01 00:00:00

abstract：:It was previously reported that in soleus neuromuscular junctions of old mice, synaptic vesicle density was decreased while transmitter release was increased (compared to results in young mice). In the present study, two hypotheses that might resolve this disparity were tested. The first was that the density of readil...

journal_title：Neurobiology of aging

authors： Fahim MA,Robbins N,Price R

更新日期：1987-01-01 00:00:00

abstract：:Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but have yet to be thoroughly investigated in sIBM. A candidate gene analys...

journal_title：Neurobiology of aging

authors： Gang Q,Bettencourt C,Machado PM,Brady S,Holton JL,Pittman AM,Hughes D,Healy E,Parton M,Hilton-Jones D,Shieh PB,Needham M,Liang C,Zanoteli E,de Camargo LV,De Paepe B,De Bleecker J,Shaibani A,Ripolone M,Violano R,Mo

更新日期：2016-11-01 00:00:00

abstract：:We conducted genetic analysis of the fused in sarcoma gene (FUS) in Chinese Han patients with essential tremor (ET) in a case-control association study. One hundred eighty unrelated patients with ET were screened for mutations in the coding region and exon-intron boundaries of FUS. Reverse transcriptase polymerase cha...

journal_title：Neurobiology of aging

authors： Zheng W,Deng X,Liang H,Song Z,Gao K,Yang Y,Deng H

更新日期：2013-08-01 00:00:00

abstract：:Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

journal_title：Neurobiology of aging

authors： Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

更新日期：2010-01-01 00:00:00

abstract：:Decreases in the activity or density of dopamine D2 receptor (D2R) have been associated with age-related changes and neurodegenerative diseases such as Parkinson's disease. There are two isoforms of the D2R, termed the D2 long receptor (D2LR) and D2 short receptor (D2SR). To study the function of these two isoforms an...

journal_title：Neurobiology of aging

authors： Fetsko LA,Xu R,Wang Y

更新日期：2005-04-01 00:00:00

abstract：:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using indepen...

journal_title：Neurobiology of aging

authors： Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

更新日期：2020-09-01 00:00:00

abstract：:The current study describes both Abeta and tau abnormalities that accumulate in the brains of aged (16-21 years), but not young (<4 years) clinically characterized cats. Diffuse plaques that were morphologically different from what is typically observed in the human brain could be detected with 4G8 (Abeta17-24) or an ...

journal_title：Neurobiology of aging

authors： Head E,Moffat K,Das P,Sarsoza F,Poon WW,Landsberg G,Cotman CW,Murphy MP

更新日期：2005-05-01 00:00:00

abstract：:Brains were examined from 22 patients with Alzheimer's disease (AD) (mean age 80.5, S.D. 11.5) and were compared with brains from 20 nondiseased subjects (mean age 81.1, S.D. 10.2). Intraneuronal lipopigment in all layers of a region of the superior frontal cortex was identified by fluorescence microscopy. The areas e...

journal_title：Neurobiology of aging

authors： Dowson JH,Mountjoy CQ,Cairns MR,Wilton-Cox H

更新日期：1992-07-01 00:00:00

abstract：:There is developing interest in the potential association between anesthesia and the onset and progression of Alzheimer's disease. Several anesthetics have, thus, been demonstrated to induce tau hyperphosphorylation, an effect mostly mediated by anesthesia-induced hypothermia. Here, we tested the hypothesis that acute...

journal_title：Neurobiology of aging

authors： Whittington RA,Virág L,Gratuze M,Petry FR,Noël A,Poitras I,Truchetti G,Marcouiller F,Papon MA,El Khoury N,Wong K,Bretteville A,Morin F,Planel E

更新日期：2015-08-01 00:00:00

abstract：:The 'amyloid hypothesis' has guided research into Alzheimer's disease (AD) for more than a decade. A detailed review of the relevant data led us to conclude that some data, particularly those from transgenic mice, are inconsistent with the predictions of the amyloid hypothesis. Instead, most data are consistent with t...

journal_title：Neurobiology of aging

authors： Bishop GM,Robinson SR

更新日期：2002-11-01 00:00:00

abstract：:The release of endogenous and newly synthesized acetylcholine (ACh) was examined in neostriatal slices prepared from young adult (10-month) and aged (28-month) Fischer 344 rats. Both spontaneous and potassium-stimulated release were tested after various in vitro incubation times (1, 3 or 5 hr). The potassium-stimulate...

journal_title：Neurobiology of aging

authors： Weiler MH

更新日期：1990-07-01 00:00:00

abstract：:The H1 MAPT haplotype in the 17q21 chromosomal region has been associated with several neurodegenerative diseases. Some reports have suggested that there is an association between genetic variants within the H1 haplotype with Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration ...

journal_title：Neurobiology of aging

authors： Ezquerra M,Pastor P,Gaig C,Vidal-Taboada JM,Cruchaga C,Muñoz E,Martí MJ,Valldeoriola F,Aguilar M,Calopa M,Hernandez-Vara J,Tolosa E

更新日期：2011-03-01 00:00:00