Abstract:
:Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the effect that is specific to chronological age remains unresolved. We present postmortem volume measurements for 26 cortical, subcortical and white matter regions, in 24 human brains aged 46-92 years, free of neuropathological abnormalities. Significant age-related loss was observed in anterior and posterior white matter but not in total grey matter volumes. Further analyses on five cortical subregions previously reported to exhibit large age-related loss on MRI yielded negative results. These analyses demonstrate smaller changes with age than those reported in imaging studies. Although this discrepancy between postmortem and imaging studies may partly be explained by the increase in noise of the neuroimaging data with age, our results suggest that healthy brain ageing is a process affecting predominantly white matter not grey matter.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GMdoi
10.1016/j.neurobiolaging.2007.10.015subject
Has Abstractpub_date
2009-08-01 00:00:00pages
1288-95issue
8eissn
0197-4580issn
1558-1497pii
S0197-4580(07)00417-4journal_volume
30pub_type
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