UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis.

abstract：:Aging, amyloid deposition, and tau-related pathology are key contributors to the onset and progression of Alzheimer's disease (AD). However, AD is also associated with brain hypometabolism and deficits of mitochondrial bioenergetics. Plasma acylcarnitines (ACCs) are indirect indices of altered fatty acid beta-oxidatio...

journal_title：Neurobiology of aging

authors： Ciavardelli D,Piras F,Consalvo A,Rossi C,Zucchelli M,Di Ilio C,Frazzini V,Caltagirone C,Spalletta G,Sensi SL

更新日期：2016-07-01 00:00:00

abstract：:Temperature regulation was evaluated in senescent (34-40 month old) and adult (8-9 month old) female Iva:WIWU and Emd:Wi-AF/Han rats. Injection of 1.5 mg/kg BW apomorphine HCl or 1.0 mg/kg BW oxotremorine sesquifumarate produced comparable maximal hypothermic responses in adult and senescent rats. However, the latency...

journal_title：Neurobiology of aging

authors： Martin JR,Fuchs A,Harting J

更新日期：1985-07-01 00:00:00

abstract：:Homozygous mutations of the glucocerebrosidase gene (GBA) cause Gaucher disease (GD), and heterozygous mutations of GBA are a major risk factor for Parkinson's disease (PD). This study examined the impact of GBA mutations on the longitudinal clinical course of PD patients by retrospective cohort design. GBA-coding reg...

journal_title：Neurobiology of aging

authors： Oeda T,Umemura A,Mori Y,Tomita S,Kohsaka M,Park K,Inoue K,Fujimura H,Hasegawa H,Sugiyama H,Sawada H

更新日期：2015-12-01 00:00:00

abstract：:Numerous types of age-related deficits in the nervous system have been well documented. While a distinction between general types of memories that are susceptible to compromise with advanced age has been fairly well agreed upon, it is often difficult to determine exactly which specific processes are detrimentally infl...

journal_title：Neurobiology of aging

authors： Churchill JD,Stanis JJ,Press C,Kushelev M,Greenough WT

更新日期：2003-10-01 00:00:00

abstract：:Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like...

journal_title：Neurobiology of aging

authors： Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

更新日期：2016-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic markers that are associated with AD status. Two of these studies suggest that an epistatic interaction between variants rs1...

journal_title：Neurobiology of aging

authors： Vance E,Gonzalez Murcia JD,Miller JB,Alzheimer's Disease Genetics Consortium (ADGC).,Staley L,Crane PK,Mukherjee S,Kauwe JSK

更新日期：2020-05-01 00:00:00

abstract：:Many elderly individuals remain dementia-free throughout their life. However, some of these individuals exhibit Alzheimer disease neuropathology on autopsy, evidenced by neurofibrillary tangles (NFTs) in AD-specific brain regions. We conducted a genome-wide association study to identify genetic mechanisms that disting...

journal_title：Neurobiology of aging

authors： Kramer PL,Xu H,Woltjer RL,Westaway SK,Clark D,Erten-Lyons D,Kaye JA,Welsh-Bohmer KA,Troncoso JC,Markesbery WR,Petersen RC,Turner RS,Kukull WA,Bennett DA,Galasko D,Morris JC,Ott J

更新日期：2011-12-01 00:00:00

abstract：:An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

journal_title：Neurobiology of aging

authors： Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

更新日期：2006-03-01 00:00:00

abstract：:The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

journal_title：Neurobiology of aging

authors： Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

更新日期：2003-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease involving motor neurons. Because a growing number of genes have been identified as the genetic etiology of ALS, simultaneous screening of mutations in multiple genes is likely to be more efficient than gene-by-gene testing. In this ...

journal_title：Neurobiology of aging

authors： Kim HJ,Oh KW,Kwon MJ,Oh SI,Park JS,Kim YE,Choi BO,Lee S,Ki CS,Kim SH

更新日期：2016-01-01 00:00:00

abstract：:Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a...

journal_title：Neurobiology of aging

authors： Salin-Pascual RJ,Upadhyay U,Shiromani PJ

更新日期：2002-09-01 00:00:00

abstract：:A circular-transcriptome-wide study has recently linked differential expression of circular RNAs (circRNAs) in brain tissue with Alzheimer's disease (AD). We aimed at replicating the major findings in an independent series of sporadic and familial AD. We also included cases with frontotemporal lobar degeneration (FTLD...

journal_title：Neurobiology of aging

authors： Cervera-Carles L,Dols-Icardo O,Molina-Porcel L,Alcolea D,Cervantes-Gonzalez A,Muñoz-Llahuna L,Clarimon J

更新日期：2020-08-01 00:00:00

abstract：:We examined the interaction of brain atrophy and white matter lesions (WML) with cognitive functioning in 605 patients (mean age, 58±10; 76% men) with atherosclerotic disease from the Second Manifestations of ARTerial disease-MR substudy (SMART-MR study). Automated brain segmentation was used to quantify volumes of br...

journal_title：Neurobiology of aging

authors： Muller M,Appelman AP,van der Graaf Y,Vincken KL,Mali WP,Geerlings MI

更新日期：2011-05-01 00:00:00

abstract：:The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when...

journal_title：Neurobiology of aging

authors： Yin W,Borniger JC,Wang X,Maguire SM,Munselle ML,Bezner KS,Tesfamariam HM,Garcia AN,Hofmann HA,Nelson RJ,Gore AC

更新日期：2019-11-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer's disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel single nucleotide polymorphisms (SNPs)-to-genes approach and functional annotation analysis. We ...

journal_title：Neurobiology of aging

authors： Ferrari R,Grassi M,Salvi E,Borroni B,Palluzzi F,Pepe D,D'Avila F,Padovani A,Archetti S,Rainero I,Rubino E,Pinessi L,Benussi L,Binetti G,Ghidoni R,Galimberti D,Scarpini E,Serpente M,Rossi G,Giaccone G,Tagliavini F

更新日期：2015-10-01 00:00:00

abstract：:Despite recognition that Alzheimer's disease (AD) is a polygenic and heterogeneous dementing neurodegenerative disorder, there is continued merit in defining the AD phenotype by the presence of progressive cognitive impairments and the pathological brain lesions (senile plaques, neurofibrillary tangles) as originally ...

journal_title：Neurobiology of aging

authors： Trojanowski JQ,Clark CM,Schmidt ML,Arnold SE,Lee VM

更新日期：1997-07-01 00:00:00

abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

journal_title：Neurobiology of aging

authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

更新日期：2001-01-01 00:00:00

abstract：:The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippo...

journal_title：Neurobiology of aging

authors： Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

更新日期：2008-09-01 00:00:00

abstract：:This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and recover less cognitive and neurologic function than younger victims. Utilizing a rat traumatic brain injury model, sham surgery or a neocortical contusion was induced in 3 ...

journal_title：Neurobiology of aging

authors： Mehan ND,Strauss KI

更新日期：2012-09-01 00:00:00

abstract：:While resting, Fischer-344 rats underwent a decrease in heart rate and an increase in diastolic blood pressure and plasma norepinephrine with increasing age. The blood pressure of adult rats increased significantly during a 3 minute immobilization. The blood pressure of old rats failed to increase during stress, decre...

journal_title：Neurobiology of aging

authors： Chiueh CC,Nespor SM,Rapoport SI

更新日期：1980-01-01 00:00:00

abstract：:Increased mitochondrial hydrogen peroxide (H2O2) is associated with Alzheimer's disease and brain aging. Peroxiredoxin 3 (Prdx3) is the key mitochondrial antioxidant defense enzyme in detoxifying H2O2. To investigate the importance of mitochondrial H2O2 in age-associated cognitive decline, we compared cognition betwee...

journal_title：Neurobiology of aging

authors： Chen L,Na R,Ran Q

更新日期：2014-11-01 00:00:00

abstract：:In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can i...

journal_title：Neurobiology of aging

authors： Wessel JR,Ullsperger M,Obrig H,Villringer A,Quinque E,Schroeter ML,Bretschneider KJ,Arelin K,Roggenhofer E,Frisch S,Klein TA

更新日期：2016-02-01 00:00:00

abstract：:Vergence eye movements were recorded with the scleral search-coil system in 32 healthy subjects (ages 19-73 years) to characterize the age-related effects on the dynamic parameters of vergence responses to step (transient components) and ramp or sinusoidal targets (sustained components) under natural viewing condition...

journal_title：Neurobiology of aging

authors： Rambold H,Neumann G,Sander T,Helmchen C

更新日期：2006-01-01 00:00:00

abstract：:A group of 51 healthy elderly volunteer subjects participated in a 3- to 6-year longitudinal study of basal cortisol levels. Once per year basal cortisol levels were examined using hourly sampling over a 24-h period. Analyses of three cortisol measures (last measure obtained, mean cortisol levels across years, and the...

journal_title：Neurobiology of aging

authors： Lupien S,Lecours AR,Schwartz G,Sharma S,Hauger RL,Meaney MJ,Nair NP

更新日期：1996-01-01 00:00:00

abstract：:The goal of this experiment was to determine the correlations among different behavioral and neurobiological measures in aged rats. Aged Sprague-Dawley rats were given a battery of cognitive and sensorimotor tests, followed by electrophysiological assessment of sleep and biochemical measurements of various neurotransm...

journal_title：Neurobiology of aging

authors： Markowska AL,Stone WS,Ingram DK,Reynolds J,Gold PE,Conti LH,Pontecorvo MJ,Wenk GL,Olton DS

更新日期：1989-01-01 00:00:00

abstract：:Decline in fluid abilities in normal aging is associated with increased white matter lesions, measured on T1-weighted images as white matter signal abnormalities (WMSAs). WMSAs are particularly evident in hypertensive older adults, suggesting vascular involvement. However, because hypertension is assessed systemically...

journal_title：Neurobiology of aging

authors： Tan CH,Low KA,Chiarelli AM,Fletcher MA,Navarra R,Burzynska AZ,Kong TS,Zimmerman B,Maclin EL,Sutton BP,Gratton G,Fabiani M

更新日期：2019-12-01 00:00:00

abstract：:Association of the A2 allele of the human leukocyte antigen (HLA) with Alzheimer disease (AD) is still controversial. The authors evaluated HLA-A2 association with AD in 173 Italian AD patients, considering also the possible interaction with APOE pattern, age of onset and gender. No evidence of any association was fou...

journal_title：Neurobiology of aging

authors： Guerini FR,Calabrese E,Agliardi C,Zanzottera M,Franceschi M,Grimaldi LM,Nemni R,Ferrante P

更新日期：2009-12-01 00:00:00

abstract：:The midsagittal cross-sectional dimensions of the corpus callosum, the coronal cross-sectional area of the lateral ventricles at the level of the pons, and a three-dimensional estimate of intracranial volume were derived from magnetic resonance brain images obtained from 45 monozygotic and 40 dizygotic male twin pairs...

journal_title：Neurobiology of aging

authors： Pfefferbaum A,Sullivan EV,Swan GE,Carmelli D

更新日期：2000-01-01 00:00:00

abstract：:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal...

journal_title：Neurobiology of aging

authors： May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

更新日期：1992-09-01 00:00:00

abstract：:Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However, the role of CLU on AD pathogenesis is not totally understood. We used cerebrospinal fluid (CSF) and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not ...

journal_title：Neurobiology of aging

authors： Deming Y,Xia J,Cai Y,Lord J,Holmans P,Bertelsen S,Holtzman D,Morris JC,Bales K,Pickering EH,Kauwe J,Goate A,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2016-01-01 00:00:00