Strategies for improving the postmortem neuropathological diagnosis of Alzheimer's disease.

abstract：:Subcortical structural changes have been reported to occur in some elderly subjects with late age onset depression. Given the association between diseases affecting subcortical structures and affective disorders, this suggests that these structural changes may be involved in the etiology of late age onset depression i...

journal_title：Neurobiology of aging

authors： Figiel GS,Krishnan KR,Doraiswamy PM,Rao VP,Nemeroff CB,Boyko OB

更新日期：1991-05-01 00:00:00

abstract：:Previous electrophysiological studies in aged rats have revealed a number of deficits in noradrenergic neurotransmission in the central nervous system. Such deficits include subsensitivity to the depressant effects of norepinephrine on cerebellar Purkinje neurons, which has been attributed specifically to altered beta...

journal_title：Neurobiology of aging

authors： Parfitt KD,Bickford-Wimer P

更新日期：1990-11-01 00:00:00

abstract：:The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, a...

journal_title：Neurobiology of aging

authors： Kalinin S,Willard SL,Shively CA,Kaplan JR,Register TC,Jorgensen MJ,Polak PE,Rubinstein I,Feinstein DL

更新日期：2013-10-01 00:00:00

abstract：:Aged, cognitively-impaired rats (and humans) show hypothalamic-pituitary-adrenal (HPA) hyperactivity that correlates with hippocampal damage. The resultant increase in plasma glucocorticoid exposure is thought to contribute to impaired hippocampal function and to potentiate hippocampal neuron death. In young, adult ra...

journal_title：Neurobiology of aging

authors： Rowe W,Steverman A,Walker M,Sharma S,Barden N,Seckl JR,Meaney MJ

更新日期：1997-09-01 00:00:00

abstract：:Discovered in the brains of multiple animal species, piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease (AD). Prefrontal cortical tissues of 6 AD cases and 6 controls were examined f...

journal_title：Neurobiology of aging

authors： Qiu W,Guo X,Lin X,Yang Q,Zhang W,Zhang Y,Zuo L,Zhu Y,Li CR,Ma C,Luo X

更新日期：2017-09-01 00:00:00

abstract：:Sleep benefits memory across a range of tasks for young adults. However, remarkably little is known of the role of sleep on memory for healthy older adults. We used 2 tasks, 1 assaying motor skill learning and the other assaying nonmotor/declarative learning, to examine off-line changes in performance in young (20-34 ...

journal_title：Neurobiology of aging

authors： Wilson JK,Baran B,Pace-Schott EF,Ivry RB,Spencer RM

更新日期：2012-05-01 00:00:00

abstract：:It was previously reported that in soleus neuromuscular junctions of old mice, synaptic vesicle density was decreased while transmitter release was increased (compared to results in young mice). In the present study, two hypotheses that might resolve this disparity were tested. The first was that the density of readil...

journal_title：Neurobiology of aging

authors： Fahim MA,Robbins N,Price R

更新日期：1987-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

journal_title：Neurobiology of aging

authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

更新日期：2014-06-01 00:00:00

abstract：:Cross-sectional studies show that elevated cerebral amyloid is associated with greater white-matter hyperintensity (WMH) burden in cognitively normal (CN) older adults. However, the relative time courses of amyloid and WMH accrual are unclear. To address this, we tested the associations between known WMH correlates-ag...

journal_title：Neurobiology of aging

authors： Scott JA,Braskie MN,Tosun D,Maillard P,Thompson PM,Weiner M,DeCarli C,Carmichael OT,ADNI.

更新日期：2016-12-01 00:00:00

abstract：:At early stages of Alzheimer's disease (AD), soluble amyloid beta (Aβ) accumulates in brain while microglia are in resting state. Microglia can recognize Aβ long after formation of plaques and release neurotoxic mediators. We examined impact of early minor activation of microglia by Toll-like receptors (TLRs) 2 and 4 ...

journal_title：Neurobiology of aging

authors： Pourbadie HG,Sayyah M,Khoshkholgh-Sima B,Choopani S,Nategh M,Motamedi F,Shokrgozar MA

更新日期：2018-10-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance...

journal_title：Neurobiology of aging

authors： Majounie E,Cross W,Newsway V,Dillman A,Vandrovcova J,Morris CM,Nalls MA,Ferrucci L,Owen MJ,O'Donovan MC,Cookson MR,Singleton AB,de Silva R,Morris HR

更新日期：2013-07-01 00:00:00

abstract：:Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases. Besides their social implications, the different forms of dementia, including Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies or frontotemporal dementia, sh...

journal_title：Neurobiology of aging

authors： Gámez-Valero A,Beyer K,Borràs FE

更新日期：2019-02-01 00:00:00

abstract：:The C9orf72 expansion is considered a major genetic cause of familial frontotemporal dementia (FTD) in several patients' cohorts. Interestingly, C9orf72 expansion carriers, present also abundant neuronal p62-positive inclusions. Although p62/SQSTM1 mutations were initially associated with Paget disease of bone (PDB), ...

journal_title：Neurobiology of aging

authors： Almeida MR,Letra L,Pires P,Santos A,Rebelo O,Guerreiro R,van der Zee J,Van Broeckhoven C,Santana I

更新日期：2016-04-01 00:00:00

abstract：:Aging is associated with alterations in different systems that govern neuronal calcium homeostasis. This study was designed to determine whether any of these alterations may contribute to the decline in spatial working memory that is observed in old rats. Several parameters [initial (5 s) and steady state (15 min) 45C...

journal_title：Neurobiology of aging

authors： Huidobro A,Blanco P,Villalba M,Gómez-Puertas P,Villa A,Pereira R,Bogónez E,Martínez-Serrano A,Aparicio JJ,Satrústegui J

更新日期：1993-09-01 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers are of use in the prediction and diagnosis of Alzheimer's disease our understanding of the background effects of age and the ApoE genotype is limited. Seventy-eight community-based normal volunteers (mean age 60+/-10 years, range 36-86) were examined to determine the relation...

journal_title：Neurobiology of aging

authors： Glodzik-Sobanska L,Pirraglia E,Brys M,de Santi S,Mosconi L,Rich KE,Switalski R,Saint Louis L,Sadowski MJ,Martiniuk F,Mehta P,Pratico D,Zinkowski RP,Blennow K,de Leon MJ

更新日期：2009-05-01 00:00:00

abstract：:The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly c...

journal_title：Neurobiology of aging

authors： Sullivan EV,Marsh L,Mathalon DH,Lim KO,Pfefferbaum A

更新日期：1995-07-01 00:00:00

abstract：:Basal forebrain cholinergic neurons (BFCN), a system involved in learning and memory processes, are highly dependent on a continuous supply of biologically active nerve growth factor (NGF). Age-related cholinergic atrophy and cell loss in normal brains is apparently not complemented by reductions in the levels of NGF ...

journal_title：Neurobiology of aging

authors： Bruno MA,Cuello AC

更新日期：2012-09-01 00:00:00

abstract：:The abnormal accumulation of amyloid fibrils in the brain is pathognomonic of Alzheimer's disease. Amyloid fibrils induce significant neuroinflammation characterized by the activation of microglia and impairment of synaptic plasticity in the brain that eventually leads to cognitive decline. Chemokine fractalkine recep...

journal_title：Neurobiology of aging

authors： Wu J,Bie B,Yang H,Xu JJ,Brown DL,Naguib M

更新日期：2013-12-01 00:00:00

abstract：:In the aging mammalian hypothalamus, a unique subpopulation of glial cells accumulates peroxidase-positive cytoplasmic inclusions distinct from lipofuscin. In adult rodents, this senescence-dependent glial granulation is accelerated by administration of estradiol valerate. In the present study, brain sections derived ...

journal_title：Neurobiology of aging

authors： Mydlarski MB,Liberman A,Schipper HM

更新日期：1995-11-01 00:00:00

abstract：:Carboxyl-terminal fragments of beta amyloid precursor protein (betaAPP) were expressed in mice under the transcriptional control of an ubiquitous promoter system, based upon a chicken beta-actin (betaA) promoter combined with cytomegalovirus (CMV) enhancer to obtain a systemic overproduction of amyloid beta protein (A...

journal_title：Neurobiology of aging

authors： Shoji M,Kawarabayashi T,Sato M,Sasaki A,Matsubara E,Igeta Y,Kanai M,Tomidokoro Y,Shizuka M,Ishiguro K,Harigaya Y,Okamoto K,Hirai S

更新日期：1998-01-01 00:00:00

abstract：:Age-related differences in opiate receptors were determined using young (1 month old), mature (3 and 8 months old) and aged (20 months old) mice. 3H-Dihydromorphine binding to mu-receptors in brain synaptic membranes consisted of two components: one with high affinity and one with low affinity. High affinity mu bindin...

journal_title：Neurobiology of aging

authors： Ueno E,Liu DD,Ho IK,Hoskins B

更新日期：1988-05-01 00:00:00

abstract：:Supporting the hypothesis that proteasome dysfunction is involved in Parkinson's disease (PD), McNaught et al. (2004) reported that the systemic administration of the proteasome inhibitor Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde (PSI) in rats led to the degeneration of the nigrostriatal pathway. However, several groups could ...

journal_title：Neurobiology of aging

authors： Shin M,Jan C,Jacquard C,Jarraya B,Callebert J,Launay JM,Hantraye P,Remy P,Palfi S,Brouillet E

更新日期：2011-11-01 00:00:00

abstract：:The apolipoprotein E (ApoE) ε4 allele has consistently been established as an Alzheimer's disease (AD) risk factor, but its pathological contribution to AD is obscure. Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ε4 allele synergistically increase the risk of AD. In addition, AD risk fact...

journal_title：Neurobiology of aging

authors： Darreh-Shori T,Modiri N,Blennow K,Baza S,Kamil C,Ahmed H,Andreasen N,Nordberg A

更新日期：2011-07-01 00:00:00

abstract：:CR1 is a novel Alzheimer's disease (AD) gene identified by genome-wide association studies (GWAS). Recently, we showed that AD risk could be explained by an 18-kilobase insertion responsible for the complement component (3b/4b) receptor 1 (CR1)-S isoform. We investigated the relevance of the CR1 isoforms to AD in a Ca...

journal_title：Neurobiology of aging

authors： Hazrati LN,Van Cauwenberghe C,Brooks PL,Brouwers N,Ghani M,Sato C,Cruts M,Sleegers K,St George-Hyslop P,Van Broeckhoven C,Rogaeva E

更新日期：2012-12-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detriti...

journal_title：Neurobiology of aging

authors： Rogers J,Webster S,Lue LF,Brachova L,Civin WH,Emmerling M,Shivers B,Walker D,McGeer P

更新日期：1996-09-01 00:00:00

abstract：:Aging-related episodic memory decline is often attributed to insufficient encoding of new information, although the underlying neural processes remain elusive. We here tested the hypothesis that impaired memory consolidation contributes to aging-related memory decline. To this end, we used resting state functional mag...

journal_title：Neurobiology of aging

authors： Kukolja J,Göreci DY,Onur ÖA,Riedl V,Fink GR

更新日期：2016-09-01 00:00:00

abstract：:Possession of an Apolipoprotein E (APOE) e4 allele is an established risk factor for Alzheimer's disease, whereas the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. Si...

journal_title：Neurobiology of aging

authors： Lancaster C,Tabet N,Rusted J

更新日期：2016-12-01 00:00:00

abstract：:In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can i...

journal_title：Neurobiology of aging

authors： Wessel JR,Ullsperger M,Obrig H,Villringer A,Quinque E,Schroeter ML,Bretschneider KJ,Arelin K,Roggenhofer E,Frisch S,Klein TA

更新日期：2016-02-01 00:00:00

abstract：:Dogs exhibit both neuroanatomical and cognitive changes as a function of age that parallel those seen in aging humans. This study describes in vivo changes in neuroanatomical and cerebrovascular characteristics of the canine brain as a function of age in a group of dogs ranging from 4 to 15 years old. Dynamic contrast...

journal_title：Neurobiology of aging

authors： Su MY,Head E,Brooks WM,Wang Z,Muggenburg BA,Adam GE,Sutherland R,Cotman CW,Nalcioglu O

更新日期：1998-09-01 00:00:00