Extracellular vesicles, new actors in the search for biomarkers of dementias.

abstract：:The effects of beta-amyloid peptide25-35 on resting membrane potential, spontaneous and evoked action potential and synaptic activity have been studied in basolateral amygdaloid complex on slices obtained from adult rats. Intracellular recordings reveal that perfusion with beta-amyloid peptide25-35 at concentrations o...

journal_title：Neurobiology of aging

authors： Ashenafi S,Fuente A,Criado JM,Riolobos AS,Heredia M,Yajeya J

更新日期：2005-04-01 00:00:00

abstract：:The density of D-1 and D-2 dopamine receptors in human caudate nucleus and putamen, obtained postmortem, were studied throughout the adult lifespan using [3H]fluphenazine as the dopamine receptor ligand. The D-1 subtype increased progressively with age in both regions, while the D-2 subtype declined in caudate nucleus...

journal_title：Neurobiology of aging

authors： Morgan DG,Marcusson JO,Nyberg P,Wester P,Winblad B,Gordon MN,Finch CE

更新日期：1987-05-01 00:00:00

abstract：:Vascular disease and Alzheimer's disease are both common disorders, in particular among elderly subjects. Therefore, it can be expected that the joint occurrence of these two disorders is not a rare phenomenon. In recent years, evidence is increasing that the two may be more closely linked than just by chance. Epidemi...

journal_title：Neurobiology of aging

authors： Breteler MM

更新日期：2000-03-01 00:00:00

abstract：:Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen rep...

journal_title：Neurobiology of aging

authors： Eberling JL,Wu C,Haan MN,Mungas D,Buonocore M,Jagust WJ

更新日期：2003-09-01 00:00:00

abstract：:The methionine/valine (M/V) polymorphism at codon 129 within the prion protein gene (PRNP) represents a known risk factor for Creutzfeldt-Jakob disease (CJD). Few authors reported also the effects of this polymorphism on the risk of Alzheimer's disease (AD), although with controversial results. To better clarify this ...

journal_title：Neurobiology of aging

authors： Del Bo R,Scarlato M,Ghezzi S,Martinelli-Boneschi F,Fenoglio C,Galimberti G,Galbiati S,Virgilio R,Galimberti D,Ferrarese C,Scarpini E,Bresolin N,Comi GP

更新日期：2006-05-01 00:00:00

abstract：:I propose that North American investigators who depend largely on individual external grants would benefit from the creation of regional facilities designed to support studies of aging in transgenic models. In general, academic institutions cannot achieve the most cost effectiveness because their facilities are not de...

journal_title：Neurobiology of aging

authors： Finch CE

更新日期：1999-03-01 00:00:00

abstract：:We designed this study to determine whether the sexual behavior of male monkeys changes on a diurnal schedule that coincides with changes in the levels of hormones such as luteinizing hormone (LH), testosterone, estradiol, and cortisol, and whether these differences vary with age. Old (n = 8) and young (n = 8) males w...

journal_title：Neurobiology of aging

authors： Chambers KC,Resko JA,Phoenix CH

更新日期：1982-04-01 00:00:00

abstract：:Open field behavior and age-related changes in anterior pituitary corticotropin-releasing hormone (CRH) receptors, as well as plasma ACTH levels, were measured in two inbred rat strains. The strains utilized were Wistar Kyoto (WKY) and Brown-Norway (BN), the former characterized by shorter life-span and hyper-reactivi...

journal_title：Neurobiology of aging

authors： Tizabi Y,Aguilera G,Gilad GM

更新日期：1992-03-01 00:00:00

abstract：:Next-generation sequencing was used to investigate 9 rare Chinese pedigrees with rare autosomal recessive neurologic Mendelian disorders. Five probands with ataxia-telangectasia and 1 proband with chorea-acanthocytosis were analyzed by targeted gene sequencing. Whole-exome sequencing was used to investigate 3 affected...

journal_title：Neurobiology of aging

authors： Chen Z,Wang JL,Tang BS,Sun ZF,Shi YT,Shen L,Lei LF,Wei XM,Xiao JJ,Hu ZM,Pan Q,Xia K,Zhang QY,Dai MZ,Liu Y,Ashizawa T,Jiang H

更新日期：2013-10-01 00:00:00

abstract：:Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and p...

journal_title：Neurobiology of aging

authors： Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L

更新日期：2011-11-01 00:00:00

abstract：:Similar to elderly humans, aged outbred Long-Evans rats exhibit individual differences in memory abilities, including a subset of aged rats that maintain memory function on par with young adults. Such individuals provide a basis for investigating mechanisms of resilience to age-related decline. The present study exami...

journal_title：Neurobiology of aging

authors： Branch A,Monasterio A,Blair G,Knierim JJ,Gallagher M,Haberman RP

更新日期：2019-04-01 00:00:00

abstract：:Flexible instrumental learning is required to harness the appropriate behaviors to obtain rewards and to avoid punishments. The precise contribution of dopaminergic midbrain regions (substantia nigra/ventral tegmental area [SN/VTA]) to this form of behavioral adaptation remains unclear. Normal aging is associated with...

journal_title：Neurobiology of aging

authors： Chowdhury R,Guitart-Masip M,Lambert C,Dolan RJ,Düzel E

更新日期：2013-10-01 00:00:00

abstract：:Modulation of insulin-dependent signaling is emerging as a valuable therapeutic tool to target neurodegeneration. In the brain, the activation of insulin receptors promotes cell growth, neuronal repair, and protection. Altered brain insulin signaling participates in the cognitive decline seen in Alzheimer's disease pa...

journal_title：Neurobiology of aging

authors： Bomba M,Granzotto A,Castelli V,Massetti N,Silvestri E,Canzoniero LMT,Cimini A,Sensi SL

更新日期：2018-04-01 00:00:00

abstract：:Increased susceptibility to energy imbalance and anorexia in old age are risk factors for malnutrition during aging, but the underlying mechanisms are not well understood. Here, we explored changes in taste-guided hedonic value ("liking") and motivation to obtain ("wanting") palatable foods as potential mediators of a...

journal_title：Neurobiology of aging

authors： Frutos MG,Pistell PJ,Ingram DK,Berthoud HR

更新日期：2012-01-01 00:00:00

abstract：:The development of amyloid imaging compounds has allowed in vivo imaging of amyloid deposition. In this study, we examined the spatial patterns of amyloid deposition throughout the brain using Pittsburgh Compound Blue ((11)C-PiB) positron emission tomography data from the Baltimore Longitudinal Study of Aging. We used...

journal_title：Neurobiology of aging

authors： Yotter RA,Doshi J,Clark V,Sojkova J,Zhou Y,Wong DF,Ferrucci L,Resnick SM,Davatzikos C

更新日期：2013-12-01 00:00:00

abstract：:Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand...

journal_title：Neurobiology of aging

authors： Bradburn S,McPhee J,Bagley L,Carroll M,Slevin M,Al-Shanti N,Barnouin Y,Hogrel JY,Pääsuke M,Gapeyeva H,Maier A,Sipilä S,Narici M,Robinson A,Mann D,Payton A,Pendleton N,Butler-Browne G,Murgatroyd C

更新日期：2018-03-01 00:00:00

abstract：:Firing characteristics of "place" cells in dorsal CA1 of hippocampus were recorded from 5 young (10-14 months) and 5 old (25-29 months) Fischer-344 rats. Animals were trained to obtain food reward on a radial 8-arm maze. Entry to the arms was controlled by the experimenter so that all 8-arm were visited in random sequ...

journal_title：Neurobiology of aging

authors： Barnes CA,McNaughton BL,O'Keefe J

更新日期：1983-07-01 00:00:00

abstract：:This paper describes regional brain energy metabolism, sensorimotor, and memory functions in mature (12 months) and old (24 months) C57BL/6 mice. Male mice were tested across a variety of sensorimotor procedures and in the Morris water maze before evaluating brain uptake of fluorodeoxyglucose (FDG) in the resting stat...

journal_title：Neurobiology of aging

authors： Uecker A,Gonzalez-Lima F,Cada A,Reiman EM

更新日期：2000-09-01 00:00:00

abstract：:The activities of presenilin 1 (PS1) and 2 modulate the proteolytic processing of amyloid precursor proteins to produce Abeta1-42, and mutations in these proteins are associated with an accelerated rate of Abeta deposition. PS1 and PS2 themselves are subject to a highly-regulated endoproteolytic cleavage to generate s...

journal_title：Neurobiology of aging

authors： Borchelt DR,Lee MK,Gonzales V,Slunt HH,Ratovitski T,Jenkins NA,Copeland NG,Price DL,Sisodia SS

更新日期：2002-03-01 00:00:00

abstract：:Aged rats show decrements in performance on cognitive tasks that require the use of spatial learning and memory. We used the 8-arm radial water maze (RAWM) to measure spatial learning as a function of age in young (6 months) and old (21 months) male F344 rats. Rats were placed in the RAWM in different start arms with ...

journal_title：Neurobiology of aging

authors： Shukitt-Hale B,McEwen JJ,Szprengiel A,Joseph JA

更新日期：2004-02-01 00:00:00

abstract：:Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incid...

journal_title：Neurobiology of aging

authors： Ferrari C,Xu WL,Wang HX,Winblad B,Sorbi S,Qiu C,Fratiglioni L

更新日期：2013-01-01 00:00:00

abstract：:Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli ...

journal_title：Neurobiology of aging

authors： Chen YC,Chen CC,Decety J,Cheng Y

更新日期：2014-04-01 00:00:00

abstract：:RACK1 (receptor for activated C-kinase 1), an anchoring protein that shuttles activated PKC to cellular membranes, plays an important role in PKC-mediated signal transduction pathways. A significant loss of RACK1 has been found in the brain of aging animals and Alzheimer's disease (AD) patients, which implicates the p...

journal_title：Neurobiology of aging

authors： Liu W,Dou F,Feng J,Yan Z

更新日期：2011-10-01 00:00:00

abstract：:Robust physiological circadian rhythms form an integral part of well-being. The aging process has been found to negatively impact systems that drive circadian physiology, typically manifesting as symptoms associated with abnormal/disrupted sleeping patterns. Here, we investigated the age-related decline in light-drive...

journal_title：Neurobiology of aging

authors： Biello SM,Bonsall DR,Atkinson LA,Molyneux PC,Harrington ME,Lall GS

更新日期：2018-06-01 00:00:00

abstract：:There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute roflumilast admini...

journal_title：Neurobiology of aging

authors： Blokland A,Van Duinen MA,Sambeth A,Heckman PRA,Tsai M,Lahu G,Uz T,Prickaerts J

更新日期：2019-05-01 00:00:00

abstract：:Neuronal alphabeta heteromeric and alpha7 homomeric nicotinic acetylcholine receptors (nAChRs) were compared in 4- and 27-month rabbits selected for learning proficiency. Sixty 4- and 60 27-month rabbits received the alpha7 nAChR agonist (MEM-3389), galantamine, or vehicle during training in trace eyeblink classical c...

journal_title：Neurobiology of aging

authors： Woodruff-Pak DS,Lehr MA,Li JG,Liu-Chen LY

更新日期：2010-06-01 00:00:00

abstract：:With aging, the brain undergoes several structural changes. These changes reflect the normal aging process and are therefore not necessarily pathologic. In fact, better understanding of these normal changes is an important cornerstone to also disentangle pathologic changes. Several studies have investigated normal bra...

journal_title：Neurobiology of aging

authors： Vinke EJ,de Groot M,Venkatraghavan V,Klein S,Niessen WJ,Ikram MA,Vernooij MW

更新日期：2018-11-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) supports the viability of midbrain dopamine (DA) neurons that degenerate in Parkinson's disease. Middle-aged, 12 month old, Gdnf heterozygous (Gdnf(+/-)) mice have diminished spontaneous locomotor activity and enhanced synaptosomal DA uptake compared with wild type mi...

journal_title：Neurobiology of aging

authors： Littrell OM,Pomerleau F,Huettl P,Surgener S,McGinty JF,Middaugh LD,Granholm AC,Gerhardt GA,Boger HA

更新日期：2012-02-01 00:00:00

abstract：:This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

journal_title：Neurobiology of aging

authors： Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2013-01-01 00:00:00

abstract：:Long-term dietary supplementation with resveratrol protects against cardiovascular disease, osteoporesis, and metabolic decline. This study determined how long-term dietary resveratrol treatment protects against retinal ganglion cell (RGC) dendrite loss after optic nerve injury and alters the resolution of the unfolde...

journal_title：Neurobiology of aging

authors： Lindsey JD,Duong-Polk KX,Hammond D,Leung CK,Weinreb RN

更新日期：2015-05-01 00:00:00