Inflammation and Alzheimer's disease pathogenesis.

abstract：:In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2A (5-HT(2A)) receptors. To establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-HT(2A) receptor and the serotonin tra...

journal_title：Neurobiology of aging

authors： Marner L,Frokjaer VG,Kalbitzer J,Lehel S,Madsen K,Baaré WF,Knudsen GM,Hasselbalch SG

更新日期：2012-03-01 00:00:00

abstract：:While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

journal_title：Neurobiology of aging

authors： Gearing M,Tigges J,Mori H,Mirra SS

更新日期：1997-03-01 00:00:00

abstract：:The excitatory amino acids (EAAs) L-aspartate and L-glutamate constitute the major neurotransmitters in the mammalian brain. This study established the influence of aging and oxidative stress on the release and uptake of EAAs. The high affinity uptake of D-[3H]aspartate in synaptosomal fractions of the neostriatum, hi...

journal_title：Neurobiology of aging

authors： Palmer AM,Robichaud PJ,Reiter CT

更新日期：1994-01-01 00:00:00

abstract：:Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine da...

journal_title：Neurobiology of aging

authors： Blazer DG,Malmrose LC,Wallsten SM,Nemeroff CB,Reed DA,Ritchie JC,Tyrey ME

更新日期：1993-01-01 00:00:00

abstract：:The G4C2 hexanucleotide repeat expansion, located in the first intron of the C9ORF72 gene, represents a major genetic hallmark of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Several hypotheses have been proposed on how the transcribed repeat RNA leads to the development of amyotrophic lateral ...

journal_title：Neurobiology of aging

authors： Šket P,Pohleven J,Kovanda A,Štalekar M,Župunski V,Zalar M,Plavec J,Rogelj B

更新日期：2015-02-01 00:00:00

abstract：:The effects of age and estradiol on hypothalamic content and distribution of tubulin and calmodulin were examined by radioimmunoassay in ovariectomized C57BL/6J female mice. A small (14%) increase in particulate tubulin, but not soluble tubulin, was found in the hypothalamus of reproductively senescent mice (20 months...

journal_title：Neurobiology of aging

authors： May PC,Finch CE

更新日期：1985-01-01 00:00:00

abstract：:The objective of this study was to determine whether physiological fluctuations in white matter (PFWM) on resting-state functional magnetic resonance images could be used as an index of neurodegeneration and Alzheimer's disease (AD). Using resting-state functional magnetic resonance image data from participants in the...

journal_title：Neurobiology of aging

authors： Makedonov I,Chen JJ,Masellis M,MacIntosh BJ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2016-01-01 00:00:00

abstract：:Accumulating evidence suggests that glycogen synthase kinase 3 (GSK-3) is a multifunctional kinase implicated in Alzheimer's disease (AD). However, the synaptic actions of GSK-3 in AD conditions are largely unknown. In this study, we examined the impact of GSK-3 on N-methyl-D-aspartate receptor (NMDAR) channels, the m...

journal_title：Neurobiology of aging

authors： Deng Y,Xiong Z,Chen P,Wei J,Chen S,Yan Z

更新日期：2014-03-01 00:00:00

abstract：:Deficits in synaptic structure and function are likely to underlie cognitive impairments in Alzheimer's disease. While synaptic deficits are commonly found in animal models of amyloidosis, it is unclear how amyloid pathology may impair synaptic functions. In some amyloid mouse models of Alzheimer's disease, however, s...

journal_title：Neurobiology of aging

authors： Cavanagh C,Tse YC,Nguyen HB,Krantic S,Breitner JC,Quirion R,Wong TP

更新日期：2016-11-01 00:00:00

abstract：:Pertinent animal models of age-related learning deficiencies are required to elucidate the mechanism of age-related learning deficiencies and to develop novel therapeutic drugs for age-related diseases such as learning defects. Among many strains of accelerated senescence prone, senescence-accelerated mouse (SAM), SAM...

journal_title：Neurobiology of aging

authors： Nomura Y,Okuma Y

更新日期：1999-03-01 00:00:00

abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

journal_title：Neurobiology of aging

authors： Ohm TG,Busch C,Bohl J

更新日期：1997-07-01 00:00:00

abstract：:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding paramet...

journal_title：Neurobiology of aging

authors： Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

更新日期：1990-07-01 00:00:00

abstract：:Accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (EVs) and be associated with the onset and the progression of Alzheimer's disease (AD). As EVs may transfer between the brain and the blood, we have thus hypoth...

journal_title：Neurobiology of aging

authors： Perrotte M,Haddad M,Le Page A,Frost EH,Fulöp T,Ramassamy C

更新日期：2020-02-01 00:00:00

abstract：:The brains of 14 rhesus monkeys (Macaca mulatta) between 4 and 35 years old were examined to determine the effects of aging on the thickness, neuronal frequency, fine structure, surface area, and volume of striate cortex. The effects of aging were ascertained by comparing the striate cortex in the six monkeys between ...

journal_title：Neurobiology of aging

authors： Peters A,Nigro NJ,McNally KJ

更新日期：1997-01-01 00:00:00

abstract：:Estrogens have been implicated as possible therapeutic agents for improving cognition in postmenopausal women and have been linked to neurodegenerative disorders such as Alzheimer's disease. However, the utility of Premarin (Wyeth Pharmaceuticals, Markham, ON, Canada), a conjugated equine estrogen and the most commonl...

journal_title：Neurobiology of aging

authors： Barha CK,Galea LA

更新日期：2013-03-01 00:00:00

abstract：:Despite cognitive and physical declines, it has been suggested that older adults remain able to regulate their emotions effectively. However, whether this is true for all emotion regulation processes has not been established. We hypothesized that cognitive reappraisal, a form of emotion regulation requiring intact cog...

journal_title：Neurobiology of aging

authors： Opitz PC,Rauch LC,Terry DP,Urry HL

更新日期：2012-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic markers that are associated with AD status. Two of these studies suggest that an epistatic interaction between variants rs1...

journal_title：Neurobiology of aging

authors： Vance E,Gonzalez Murcia JD,Miller JB,Alzheimer's Disease Genetics Consortium (ADGC).,Staley L,Crane PK,Mukherjee S,Kauwe JSK

更新日期：2020-05-01 00:00:00

abstract：:Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel ...

journal_title：Neurobiology of aging

authors： Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1993-01-01 00:00:00

abstract：:Modified forms of tau proteins are major components of the paired helical filaments (PHFs) present in Alzheimer brains. In this study, tau from cytosolic samples obtained from normal and Alzheimer disease brains were fractionated by iron-chelated affinity chromatography (ICAC) to discriminate between isoforms phosphor...

journal_title：Neurobiology of aging

authors： Ledesma MD,Avila J,Correas I

更新日期：1995-07-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/TauP301L) brains. We established an in vitro model of primary neurona...

journal_title：Neurobiology of aging

authors： Han P,Tang Z,Yin J,Maalouf M,Beach TG,Reiman EM,Shi J

更新日期：2014-09-01 00:00:00

abstract：:Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neuroto...

journal_title：Neurobiology of aging

authors： Galvan L,Lepejová N,Gaillard MC,Malgorn C,Guillermier M,Houitte D,Bonvento G,Petit F,Dufour N,Héry P,Gérard M,Elalouf JM,Déglon N,Brouillet E,de Chaldée M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

journal_title：Neurobiology of aging

authors： Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

更新日期：2010-04-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00

abstract：:To investigate possible age-associated changes in human synaptic connectivity, superior-middle frontal cortex (Brodmann area 9) was evaluated with ultrastructural techniques. Short post mortem autopsy tissue was obtained from 37 cognitive normal individuals ranging in age from 20 to 89 years. A minimum of five subject...

journal_title：Neurobiology of aging

authors： Scheff SW,Price DA,Sparks DL

更新日期：2001-05-01 00:00:00

abstract：:Open field behavior and age-related changes in anterior pituitary corticotropin-releasing hormone (CRH) receptors, as well as plasma ACTH levels, were measured in two inbred rat strains. The strains utilized were Wistar Kyoto (WKY) and Brown-Norway (BN), the former characterized by shorter life-span and hyper-reactivi...

journal_title：Neurobiology of aging

authors： Tizabi Y,Aguilera G,Gilad GM

更新日期：1992-03-01 00:00:00

abstract：:Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amylo...

journal_title：Neurobiology of aging

authors： DeMichele-Sweet MA,Klei L,Devlin B,Ferrell RE,Weamer EA,Emanuel JE,Lopez OL,Sweet RA

更新日期：2011-03-01 00:00:00

abstract：:Recent case-control studies reported an association between H. pylori infection and Alzheimer's disease (AD). Our aim was to compare cognitive impairment, neuroinflammation, and cerebrovascular lesion load in a group of AD patients according to their H. pylori status. For the 53 AD patients included, we assessed: clin...

journal_title：Neurobiology of aging

authors： Roubaud-Baudron C,Krolak-Salmon P,Quadrio I,Mégraud F,Salles N

更新日期：2012-05-01 00:00:00

abstract：:Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incid...

journal_title：Neurobiology of aging

authors： Ferrari C,Xu WL,Wang HX,Winblad B,Sorbi S,Qiu C,Fratiglioni L

更新日期：2013-01-01 00:00:00

abstract：:We evaluated pathomechanisms and systemic manifestations of Alzheimer disease (AD), an aging-related dementing neurodegenerative disorder, by expression profiling. Blood mononuclear cell (BMC) transcriptomes of sporadic AD subjects and aged-matched normal elderly controls (NEC) were compared using the human NIA microa...

journal_title：Neurobiology of aging

authors： Maes OC,Xu S,Yu B,Chertkow HM,Wang E,Schipper HM

更新日期：2007-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of motor neurons. To date, more than 20 genes have been implicated in ALS, and of these, the 2 most frequently mutated are the superoxide dismutase 1 (SOD1) gene and the chromosome 9 open reading frame 72 (C9ORF72) gene. In t...

journal_title：Neurobiology of aging

authors： Tripolszki K,Csányi B,Nagy D,Ratti A,Tiloca C,Silani V,Kereszty É,Török N,Vécsei L,Engelhardt JI,Klivényi P,Nagy N,Széll M

更新日期：2017-05-01 00:00:00