Omegaconotoxin binding decreases in aged rat brain.

Abstract:

:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

doi

10.1016/0197-4580(90)90010-w

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

433-6

issue

4

eissn

0197-4580

issn

1558-1497

pii

0197-4580(90)90010-W

journal_volume

11

pub_type

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