Abstract:
:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding parameters were unmodified in hippocampus of the two age groups. These data are consistent with the decrease of calcium uptake and neurotransmitter release observed in the brain of aged rodents.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi Mdoi
10.1016/0197-4580(90)90010-wsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
433-6issue
4eissn
0197-4580issn
1558-1497pii
0197-4580(90)90010-Wjournal_volume
11pub_type
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