Abstract：
:Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel difference images were computed by contrasting flow during a control task to flow during face matching. Both patients and controls showed bilateral rCBF increases in occipitotemporal extrastriate cortex during face matching. The magnitude of these increases was not significantly different between the groups. In addition, the patients showed greater rCBF activation in regions of occipital and frontal cortex. These results show that early in the course of DAT, patients utilize extrastriate cortex to perform a visuoperceptual task, as do control subjects but also show rCBF increases in additional cortical areas. Activation of these additional areas of cortex in the patients may reflect an increased attentional load during face matching due to their reduced cognitive capacity.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SIdoi
10.1016/0197-4580(93)90018-7subject
Has Abstractpub_date
1993-01-01 00:00:00pages
35-44issue
1eissn
0197-4580issn
1558-1497pii
0197-4580(93)90018-7journal_volume
14pub_type
杂志文章abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...
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