Abstract:
:Alzheimer's disease (AD) is the most common cause of dementia and, despite decades of effort, there is no effective treatment. In the last decade, many association studies have identified genetic markers that are associated with AD status. Two of these studies suggest that an epistatic interaction between variants rs1049296 in the transferrin (TF) gene and rs1800562 in the homeostatic iron regulator (HFE) gene, commonly known as hemochromatosis, is in genetic association with AD. TF and HFE are involved in the transport and regulation of iron in the brain, and disrupting these processes exacerbates AD pathology through increased neurodegeneration and oxidative stress. However, by using a significantly larger data set from the Alzheimer's Disease Genetics Consortium, we fail to detect an association between TF rs1049296 or HFE rs1800562 with AD risk (TF rs1049296 p = 0.38 and HFE rs1800562 p = 0.40). In addition, logistic regression with an interaction term and a synergy factor analysis both failed to detect epistasis between TF rs1049296 and HFE rs1800562 (SF = 0.94; p = 0.48) in AD cases. Each of these analyses had sufficient statistical power (power > 0.99), suggesting that previously reported associations may be the result of more complex epistatic interactions, genetic heterogeneity, or false-positive associations because of limited sample sizes.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Vance E,Gonzalez Murcia JD,Miller JB,Alzheimer's Disease Genetics Consortium (ADGC).,Staley L,Crane PK,Mukherjee S,Kauwe JSKdoi
10.1016/j.neurobiolaging.2020.01.013subject
Has Abstractpub_date
2020-05-01 00:00:00pages
142.e9-142.e12eissn
0197-4580issn
1558-1497pii
S0197-4580(20)30027-0journal_volume
89pub_type
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