当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.

Rhythmicity and response to A.M. and P.M. CRH challenge in elderly subjects.

Abstract：

:Cortisol and ACTH exhibit circadian rhythmicity, peaking in the early morning. These peaks are associated with increased activity and alertness. We sought to determine whether self-reported daily rhythms predict outcome of a.m. and p.m. CRH challenge in elderly subjects. We surveyed 96 elderly subjects to determine daily rhythms in activity levels, mood, alertness, and performance. Seven healthy subjects were given a cumulative activity score reflecting propensity toward morningness or eveningness. Subjects underwent CRH challenge testing during the morning and evening hours of different days. Baseline plasma ACTH and cortisol concentrations were higher in the morning than in the evening and lower values were associated with lower activity scores (i.e., greater morningness). No trends were apparent between activity score and net hormone response or percent change in hormone concentration.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Blazer DG,Malmrose LC,Wallsten SM,Nemeroff CB,Reed DA,Ritchie JC,Tyrey ME

doi

10.1016/0197-4580(93)90029-b

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

101-6

issue

1

eissn

0197-4580

issn

1558-1497

pii

0197-4580(93)90029-B

journal_volume

14

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice.

    abstract：:Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by extensive deposition of fibrillar amyloid-β (Aβ) in the brain. Previously, myelin basic protein (MBP) was identified to be a potent inhibitor to Aβ fibril formation, and this inhibitory activity was localized to the N-terminal res...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.10.006

    authors： Ou-Yang MH,Xu F,Liao MC,Davis J,Robinson JK,Van Nostrand WE

    更新日期：2015-02-01 00:00:00

  • Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: neuroimaging evidence for protection and compensation.

    abstract：:The brain mechanisms underlying the effect of intellectual enrichment may evolve along the normal aging Alzheimer's disease (AD) cognitive spectrum and may include both protective and compensatory mechanisms. We assessed the association between early intellectual enrichment (education, years) and average cortical flor...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.06.016

    authors： Arenaza-Urquijo EM,Bejanin A,Gonneaud J,Wirth M,La Joie R,Mutlu J,Gaubert M,Landeau B,de la Sayette V,Eustache F,Chételat G

    更新日期：2017-11-01 00:00:00

  • Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment.

    abstract：:Similar to elderly humans, aged outbred Long-Evans rats exhibit individual differences in memory abilities, including a subset of aged rats that maintain memory function on par with young adults. Such individuals provide a basis for investigating mechanisms of resilience to age-related decline. The present study exami...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.12.015

    authors： Branch A,Monasterio A,Blair G,Knierim JJ,Gallagher M,Haberman RP

    更新日期：2019-04-01 00:00:00

  • Age effects on gray matter volume and attentional performance in Zen meditation.

    abstract：:Zen meditation, a Buddhist practice centered on attentional and postural self-regulation, has been speculated to bring about beneficial long-term effects for the individual, ranging from stress reduction to improvement of cognitive function. In this study, we examined how the regular practice of meditation may affect ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.06.008

    authors： Pagnoni G,Cekic M

    更新日期：2007-10-01 00:00:00

  • The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease.

    abstract：:Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer's disease patients and mouse models display age-related or amyloid-β peptide (Aβ)-induced reductions in CD200. The goal of this study was to dete...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.07.027

    authors： Varnum MM,Kiyota T,Ingraham KL,Ikezu S,Ikezu T

    更新日期：2015-11-01 00:00:00

  • Aβ induces its own prion protein N-terminal fragment (PrPN1)-mediated neutralization in amorphous aggregates.

    abstract：:Plasma membrane cellular prion protein (PrP(C)) is a high-affinity receptor for toxic soluble amyloid-β (Aβ) oligomers that mediates synaptic dysfunction. Secreted forms of PrP(C) resulting from PrP(C) α-cleavage (PrPN1) or shedding (shed PrP(C)) display neuroprotective activity in neuronal cultures and in mouse model...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.02.001

    authors： Béland M,Bédard M,Tremblay G,Lavigne P,Roucou X

    更新日期：2014-07-01 00:00:00

  • Neurovascular coupling in Alzheimer patients: effect of acetylcholine-esterase inhibitors.

    abstract：:Dualistic effects of acetylcholine-esterase inhibitors on neuronal as well as vasoregulative function have been debated. This study investigated for the first time effects of medication on both components. Visually evoked potentials and resultant hemodynamic responses were assessed in Alzheimer patients (n=31) without...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.02.017

    authors： Rosengarten B,Paulsen S,Burr O,Kaps M

    更新日期：2009-12-01 00:00:00

  • Genetics and Alzheimer's disease: notes of an environment watcher (with apologies to L. Thomas).

    abstract：:Support has recently been voiced for the genetic hypothesis of Alzheimer's disease; frequently at the expense of considerations of environmental factors. In the adult, genetic diseases rarely exist without modification by environment forces. Atherosclerosis leading to myocardial infarction may provide a useful model t...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(89)90093-6

    authors： Perl DP

    更新日期：1989-09-01 00:00:00

  • The frequency of the C9orf72 expansion in a Brazilian population.

    abstract：:G4C2 hexanucleotide repeat expansions in the C9orf72 gene seem to be the cause of numerous cases of amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD). In this study, we investigated the presence of the G4C2 repeat expansion in 463 Brazilian probands, of whom 404 had ALS/motor neuron disease and ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.01.007

    authors： Cintra VP,Bonadia LC,Andrade HMT,de Albuquerque M,Eusébio MF,de Oliveira DS,Claudino R,Gonçalves MVM,Teixeira AL Jr,de Godoy Rousseff Prado L,de Souza LC,Dourado MET Jr,Oliveira ASB,Tumas V,França MC Jr,Marques W Jr

    更新日期：2018-06-01 00:00:00

  • Use of tissue culture models to study neuronal regulatory trophic and toxic factors in the aged brain.

    abstract：:Dementia is believed to result from the loss of selective neurons within the brain, but approaches for systematic study of that degenerative process are hampered by the complexity of the neuronal milieu. Tissue culture models provide a means to reduce dramatically the variables inherent in the study of neuronal plasti...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(88)80142-8

    authors： Azmitia EC,Whitaker-Azmitia PM,Bartus R

    更新日期：1988-09-01 00:00:00

  • Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative.

    abstract：:This study modeled predementia Alzheimer's disease clinical trials. Longitudinal data from cognitively normal (CN) and mild cognitive impairment (MCI) participants in the Alzheimer's Disease Neuroimaging Initiative were used to calculate sample size requirements for trials using outcome measures, including the Clinica...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.03.006

    authors： Grill JD,Di L,Lu PH,Lee C,Ringman J,Apostolova LG,Chow N,Kohannim O,Cummings JL,Thompson PM,Elashoff D,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2013-01-01 00:00:00

  • Medial septal and nucleus basalis magnocellularis lesions produce order memory deficits in rats which mimic symptomatology of Alzheimer's disease.

    abstract：:Rats with electrolytic lesions of the medial septum or ibotenic acid lesions of the nucleus basalis magnocellularis (NBM) were tested in an order memory task for an 8-item list of varying spatial locations within an 8-arm radial maze. Results indicated that rats with small medial septal lesions resulting in small AchE...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(86)90009-6

    authors： Kesner RP,Crutcher KA,Measom MO

    更新日期：1986-07-01 00:00:00

  • Neuropathological criteria for the diagnosis of Alzheimer's disease.

    abstract：:The definitive diagnosis of Alzheimer's disease (AD) is made at autopsy by the presence of abundant neuritic plaques (NP) and neurofibrillary tangles (NFT) in the neocortex, entorhinal cortex, and hippocampus. The two criteria most frequently used by neuropathologists for the diagnosis of AD over the past 12 years are...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/s0197-4580(97)00064-x

    authors： Markesbery WR

    更新日期：1997-07-01 00:00:00

  • Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat.

    abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(00)00194-9

    authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

    更新日期：2001-01-01 00:00:00

  • Expanding the role of education in frontotemporal dementia: a functional dynamic connectivity (the chronnectome) study.

    abstract：:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using indepen...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.04.021

    authors： Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

    更新日期：2020-09-01 00:00:00

  • VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China.

    abstract：:The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, t...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.003

    authors： Chen Y,Chen K,Song W,Chen X,Cao B,Huang R,Zhao B,Guo X,Burgunder J,Li J,Shang HF

    更新日期：2013-06-01 00:00:00

  • Total tau is increased, but phosphorylated tau not decreased, in cerebrospinal fluid in amyotrophic lateral sclerosis.

    abstract：:In amyotrophic lateral sclerosis (ALS), objective biomarkers are needed for early diagnosis and progression monitoring. Reduced phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) has recently been proposed to provide such a biomarker in ALS. Here, we aimed to scrutinize this notion, evaluating both p-tau and tota...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.10.019

    authors： Wilke C,Deuschle C,Rattay TW,Maetzler W,Synofzik M

    更新日期：2015-02-01 00:00:00

  • Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.

    abstract：:It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day o...

    journal_title：Neurobiology of aging

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.neurobiolaging.2011.02.013

    authors： Lövdén M,Schaefer S,Noack H,Bodammer NC,Kühn S,Heinze HJ,Düzel E,Bäckman L,Lindenberger U

    更新日期：2012-03-01 00:00:00

  • Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.

    abstract：:At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early neurodegeneration of the dendritic inhibitory interneurons (oriens-lacunosum moleculare, O-LM, an...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.09.022

    authors： Ramos B,Baglietto-Vargas D,del Rio JC,Moreno-Gonzalez I,Santa-Maria C,Jimenez S,Caballero C,Lopez-Tellez JF,Khan ZU,Ruano D,Gutierrez A,Vitorica J

    更新日期：2006-11-01 00:00:00

  • Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.

    abstract：:The mechanism by which amyloid beta (Aβ) causes neuronal dysfunction and/or death in Alzheimer's disease (AD) is unclear. Previously, we showed that Aβ inhibits several microtubule-dependent kinesin motors essential for mitosis and also present in mature neurons. Here, we show that inhibition of kinesin 5 (Eg5) by Aβ ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.02.006

    authors： Ari C,Borysov SI,Wu J,Padmanabhan J,Potter H

    更新日期：2014-08-01 00:00:00

  • Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism.

    abstract：:The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00135-5

    authors： Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

    更新日期：2003-05-01 00:00:00

  • GSK3β polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort.

    abstract：:To determine whether polymorphisms in the microtubule-associated protein tau (MAPT) and/or glycogen synthase kinase-3β (GSK3β) genes underpin susceptibility to Parkinson's disease (PD), we conducted a case-control association study in a Greek cohort of 196 PD cases and 163 healthy controls. In our study, the MAPT H1 h...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.05.007

    authors： Kalinderi K,Fidani L,Katsarou Z,Clarimón J,Bostantjopoulou S,Kotsis A

    更新日期：2011-03-01 00:00:00

  • Effects of caloric restriction on O-GlcNAcylation, Ca(2+) signaling, and learning impairment in the hippocampus of ob/ob mice.

    abstract：:Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.05.002

    authors： Jeon BT,Heo RW,Jeong EA,Yi CO,Lee JY,Kim KE,Kim H,Roh GS

    更新日期：2016-08-01 00:00:00

  • Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

    abstract：:Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.005

    authors： Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

    更新日期：2013-05-01 00:00:00

  • MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD.

    abstract：:The substantia innominata (SI) contains the nucleus basalis of Meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in Alzheimer's disease (AD). However, whether SI atrophy occurs in individua...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2009.11.006

    authors： George S,Mufson EJ,Leurgans S,Shah RC,Ferrari C,deToledo-Morrell L

    更新日期：2011-10-01 00:00:00

  • Genetic association of low density lipoprotein receptor and Alzheimer's disease.

    abstract：:The low density lipoprotein receptor (LDLR) is an attractive candidate gene for genetic association with Alzheimer's disease (AD) because: (i) the LDLR is an apolipoprotein E (apoE) receptor, alleles of which have been associated with AD, (ii) LDLR resides at chromosome 19p13.3 within a region linked to AD, and (iii) ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.09.001

    authors： Gopalraj RK,Zhu H,Kelly JF,Mendiondo M,Pulliam JF,Bennett DA,Estus S

    更新日期：2005-01-01 00:00:00

  • Neurotoxicity and synaptic plasticity impairment of N-acetylglucosamine polymers: implications for Alzheimer's disease.

    abstract：:We assessed whether polymers of N-acetylglucosamine (GlcNAc) have any pathogenetic role in Alzheimer's disease (AD). First, by using specific dyes, we found deposits of polymers of GlcNAc in sporadic but not in familial AD. We found that neurons and microglia exposed to GlcNAc and uridine diphosphate (UDP)-GlcNAc are ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.12.033

    authors： Turano E,Busetto G,Marconi S,Guzzo F,Farinazzo A,Commisso M,Bistaffa E,Angiari S,Musumeci S,Sotgiu S,Bonetti B

    更新日期：2015-05-01 00:00:00

  • Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region.

    abstract：:We used high-resolution MRI to investigate gray and white matter aging in the major lobes of the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe (temporal pole, superior temporal gyrus, infero-temporal region, parahippocampal gyrus, amygdala, hippocampus). Subjects included...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.05.023

    authors： Allen JS,Bruss J,Brown CK,Damasio H

    更新日期：2005-10-01 00:00:00

  • Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function.

    abstract：:Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.05.006

    authors： Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

    更新日期：2010-01-01 00:00:00

  • BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signaling events.

    abstract：:Brain-derived neurotrophic factor (BDNF) has emerged as a major regulator of synaptic plasticity in the adult brain and acute BDNF infusion has been shown to trigger long-term potentiation (BDNF-LTP) in adult rats. Here we compared the effects of acute BDNF infusion in young adult and aged anesthetized rats. In young ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.01.003

    authors： Gooney M,Messaoudi E,Maher FO,Bramham CR,Lynch MA

    更新日期：2004-11-01 00:00:00