Abstract:
:Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian disorder. Abnormal tau inclusions, in selected regions of the brain, are a hallmark of the disease and the H1 haplotype of MAPT, the gene encoding tau, is the major risk factor in PSP. A 3-repeat and 4-repeat (4R) tau isoform ratio imbalance has been strongly implicated as a cause of disease. Thus, understanding tau isoform regional expression in disease and pathology-free states is crucial to elucidating the mechanisms involved in PSP and other tauopathies. We used a tau isoform-specific fluorescent assay to investigate relative 4R-tau expression in 6 different brain regions in PSP cases and healthy control samples. We identified a marked difference in 4R-tau relative expression, across brain regions and between MAPT haplotypes. Highest 4R-tau expression levels were identified in the globus pallidus compared with pons, cerebellum, and frontal cortex. 4R-tau expression levels were related to the MAPT H1 and H1c haplotypes. Similar regional variation was seen in PSP case and in control samples.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Majounie E,Cross W,Newsway V,Dillman A,Vandrovcova J,Morris CM,Nalls MA,Ferrucci L,Owen MJ,O'Donovan MC,Cookson MR,Singleton AB,de Silva R,Morris HRdoi
10.1016/j.neurobiolaging.2013.01.017subject
Has Abstractpub_date
2013-07-01 00:00:00pages
1922.e7-1922.e12issue
7eissn
0197-4580issn
1558-1497pii
S0197-4580(13)00047-Xjournal_volume
34pub_type
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