Abstract:
:The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Braae A,Medway C,Carrasquillo M,Younkin S,Alzheimer's Research UK (ARUK) Consortium.,Kehoe PG,Morgan Kdoi
10.1016/j.neurobiolaging.2015.01.013subject
Has Abstractpub_date
2015-04-01 00:00:00pages
1767.e1-1767.e2issue
4eissn
0197-4580issn
1558-1497pii
S0197-4580(15)00046-9journal_volume
36pub_type
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