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Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer's disease.

Abstract：

:The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzheimer's disease. In this article, we summarize clinical trials and case reports on fornix deep brain stimulation for Alzheimer's disease and review experiments on animal models evaluating the physiological or behavioral effects of this intervention. Based on information from these reports and studies, we identify potential translational challenges of this approach and determine practical and ethical considerations for clinical trials, focusing on issues regarding selection criteria, trial design, and outcome evaluation. Based on initial results suggesting greater benefit for those with milder disease stage, we find it essential that participant expectations are carefully managed to avoid treatment disenchantment and/or frustration from participants and caregivers. Finally, we urge for collaboration between centers to establish proper clinical standards and to promote better trial results comparison.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Viaña JNM,Vickers JC,Cook MJ,Gilbert F

doi

10.1016/j.neurobiolaging.2017.03.001

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

202-210

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(17)30072-6

journal_volume

56

pub_type

杂志文章,评审

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