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Age-dependent effect of cholinergic lesion on dendritic morphology in rat frontal cortex.

Abstract：

:Previously, we demonstrated that plasticity of frontal cortex is altered in aging rats: 3 months after surgery, excitotoxic lesions of the nucleus basalis magnocellularis (NBM) produce larger declines in dendritic morphology in frontal cortex of aged rats relative to young adults. To determine whether the differential effect of the lesion was due specifically to loss of cholinergic input from the NBM, we assessed dendritic morphology in frontal cortex after specific cholinergic depletion in young adult, middle-aged, and aged male rats. Rats received unilateral sham or 192-IgG-saporin lesions of the NBM. Two weeks after surgery, brains were stained using a Golgi-Cox procedure. Dendritic morphology was quantified in pyramidal neurons in layers II-III of frontal cortex. Although lesions altered apical dendrites at all ages, these effects were most pronounced in aged rats. In addition, lesions produced marked atrophy of basilar dendrites in middle-aged and aged rats only. Thus, the differential dendritic atrophy resulting from NBM lesions in aged rats occurs within 2 weeks after lesion, and results specifically from loss of cholinergic innervation.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Works SJ,Wilson RE,Wellman CL

doi

10.1016/j.neurobiolaging.2003.08.003

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

963-74

issue

7

eissn

0197-4580

issn

1558-1497

pii

S0197458003001878

journal_volume

25

pub_type

杂志文章

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