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Increased caveolin-1 expression in Alzheimer's disease brain.

Abstract：

:Increasing evidence suggests that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol transport. We investigated the changes in the protein amount of hippocampal caveolin of autopsy-confirmed AD and aged-matched control subjects. Our results demonstrate that caveolin protein levels in the hippocampus and caveolin mRNA in the frontal cortex are up-regulated in AD by approximately two-fold, compared to control brains. These results suggest a relationship between caveolin-1 expression levels and a dysregulation of cholesterol homeostasis at the plasma membrane of brain cells. In support of this hypothesis, a significant increase in caveolin protein levels has also been observed in hippocampal tissue from ApoE-deficient (knockout) and aged wild-type mice; two situations associated with modifications of transbilayer distribution of cholesterol in brain synaptic plasma membranes. These results indicate that caveolin over-expression is linked to alterations of cholesterol distribution in the plasma membrane of brain cells and are consistent with the notion of a deterioration of cholesterol homeostasis in AD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Gaudreault SB,Dea D,Poirier J

doi

10.1016/j.neurobiolaging.2003.07.004

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

753-9

issue

6

eissn

0197-4580

issn

1558-1497

pii

S0197458003001866

journal_volume

25

pub_type

杂志文章

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