Sex differences in risk factors for white matter hyperintensities in non-demented older individuals.

abstract：:Visual function declines with age. This deterioration results not only from changes in the optical system but also from the functional degradation of the central visual cortex. Although numerous studies have explored the mechanisms of age-related influences on vision, they have failed to acknowledge the significance o...

journal_title：Neurobiology of aging

authors： Wang X,Zhang B,Wang H,Liu J,Xu G,Zhou Y

更新日期：2019-04-01 00:00:00

abstract：:Striatal degeneration may contribute to cognitive impairment in older people. Here, we examine the relation of degeneration of the striatum and substructures to cognitive decline and dementia in subjects with a wide range of cognitive function. Data are from the prospective community-based Honolulu Asia Aging Study of...

journal_title：Neurobiology of aging

authors： de Jong LW,Wang Y,White LR,Yu B,van Buchem MA,Launer LJ

更新日期：2012-02-01 00:00:00

abstract：:After a decade of intense study of cholinergic therapies for Alzheimer's disease, three conditions in this field are apparent: 1) The potential that cholinergic agents will ameliorate the memory dysfunction of Alzheimer patients (as 1-dopa benefits Parkinson patients) is still a stimulus for research. 2) Cholinergic n...

journal_title：Neurobiology of aging

authors： Ashford JW,Sherman KA,Kumar V

更新日期：1989-01-01 00:00:00

abstract：:Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in b...

journal_title：Neurobiology of aging

authors： Metastasio A,Rinaldi P,Tarducci R,Mariani E,Feliziani FT,Cherubini A,Pelliccioli GP,Gobbi G,Senin U,Mecocci P

更新日期：2006-07-01 00:00:00

abstract：:To study the long-term effects of prenatal diazepam (DZ) exposure, 31P NMR (nuclear magnetic resonance) spectra and levels of thiobarbituric acid (TBA)-reactive material were measured in the brains of rats from 3 to 26 months of age. In control rats, there were aging-related increases in levels of TBA-reactive materia...

journal_title：Neurobiology of aging

authors： Miranda R,Ceckler T,Guillet R,Kellogg CK

更新日期：1990-03-01 00:00:00

abstract：:GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinica...

journal_title：Neurobiology of aging

authors： Sellami L,Rucheton B,Ben Younes I,Camuzat A,Saracino D,Rinaldi D,Epelbaum S,Azuar C,Levy R,Auriacombe S,Hannequin D,Pariente J,Barbier M,Boutoleau-Bretonnière C,Couratier P,Pasquier F,Deramecourt V,Sauvée M,Sarazin M

更新日期：2020-07-01 00:00:00

abstract：:New highly-accurate stereological methods for estimating the total numbers of neurons in brain structures have been used to test for age-related neuron loss in the human hippocampal formation. Across the age range of 13 to 85 years, there was a substantial loss of neurons in the subiculum (52%) and in the hilus of the...

journal_title：Neurobiology of aging

authors： West MJ

更新日期：1993-07-01 00:00:00

abstract：:We have assessed the frequency of alpha-synuclein (SNCA) mutations in Japanese patients with familial or sporadic Parkinson's disease (PD) and surveyed their associated clinical manifestations. We screened SNCA exon 3 in 988 patients without SNCA multiplications (430 with autosomal dominant PD and 558 with sporadic PD...

journal_title：Neurobiology of aging

authors： Yoshino H,Hirano M,Stoessl AJ,Imamichi Y,Ikeda A,Li Y,Funayama M,Yamada I,Nakamura Y,Sossi V,Farrer MJ,Nishioka K,Hattori N

更新日期：2017-09-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular basement membrane, and have been shown to be altered in patients with Alzheimer's Disease (AD). Although the HSPG agrin clearly orchestrates the differentiation of the neuromuscular junction, its role in the brain remains unclear. G...

journal_title：Neurobiology of aging

authors： Berzin TM,Zipser BD,Rafii MS,Kuo-Leblanc V,Yancopoulos GD,Glass DJ,Fallon JR,Stopa EG

更新日期：2000-03-01 00:00:00

abstract：:While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28...

journal_title：Neurobiology of aging

authors： Gearing M,Tigges J,Mori H,Mirra SS

更新日期：1997-03-01 00:00:00

abstract：:Healthy aged adult (24-26 months of age) and young adult (2-4 months of age) c57BL/6J male mice were assessed for intermale aggression, pup-killing behavior (infanticide), and circulating levels of testosterone (T). When compared to young adult male mice, aged adult males were highly variable in the exhibition of both...

journal_title：Neurobiology of aging

authors： Svare B,Mann M,Broida J,Kinsley C,Ghiraldi L,Miele J,Konen C

更新日期：1983-01-01 00:00:00

abstract：:Dementia with Lewy bodies (DLB) is characterized by preserved whole brain and medial temporal lobe volumes compared with Alzheimer's disease dementia (AD) on magnetic resonance imaging. However, frequently coexistent AD-type pathology may influence the pattern of regional brain atrophy rates in DLB patients. We invest...

journal_title：Neurobiology of aging

authors： Nedelska Z,Ferman TJ,Boeve BF,Przybelski SA,Lesnick TG,Murray ME,Gunter JL,Senjem ML,Vemuri P,Smith GE,Geda YE,Graff-Radford J,Knopman DS,Petersen RC,Parisi JE,Dickson DW,Jack CR Jr,Kantarci K

更新日期：2015-01-01 00:00:00

abstract：:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using indepen...

journal_title：Neurobiology of aging

authors： Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

更新日期：2020-09-01 00:00:00

abstract：:Cerebral small vessel disease (SVD) and inflammation are increasingly recognized as key contributors to Alzheimer's disease (AD), although the timing, trajectory, and relation between them early in the disease process is unclear. Therefore, to investigate very early-stage changes, we compared 158 healthy midlife adult...

journal_title：Neurobiology of aging

authors： Low A,Su L,Stefaniak JD,Mak E,Dounavi ME,Muniz-Terrera G,Ritchie K,Ritchie CW,Markus HS,O'Brien JT

更新日期：2020-11-02 00:00:00

abstract：:We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar re...

journal_title：Neurobiology of aging

authors： Möller C,Hafkemeijer A,Pijnenburg YAL,Rombouts SARB,van der Grond J,Dopper E,van Swieten J,Versteeg A,Steenwijk MD,Barkhof F,Scheltens P,Vrenken H,van der Flier WM

更新日期：2016-02-01 00:00:00

abstract：:Deletions of the mitochondrial DNA (mtDNA) have been shown to accumulate with age in a variety of species regardless of mean or maximal life span. This implies that such mutations are either a molecular biomarker of senescence or that they are more causally linked to senescence itself. One assay that can be used to de...

journal_title：Neurobiology of aging

authors： Melov S,Schneider JA,Coskun PE,Bennett DA,Wallace DC

更新日期：1999-09-01 00:00:00

abstract：:The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a w...

journal_title：Neurobiology of aging

authors： Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

更新日期：1992-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) deposition and neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker degrees and patterns of Aβ deposition, glucose hypometabolism, and gray matter volume (GMV) reduction in 3 groups at risk of AD. In elderly...

journal_title：Neurobiology of aging

authors： Wirth M,Bejanin A,La Joie R,Arenaza-Urquijo EM,Gonneaud J,Landeau B,Perrotin A,Mézenge F,de La Sayette V,Desgranges B,Chételat G

更新日期：2018-03-01 00:00:00

abstract：:The perimenopausal transition at middle age is often associated with hot flashes and sleep disruptions, metabolic changes, and other symptoms. Whereas the mechanisms for these processes are incompletely understood, both aging (AG) and a loss of ovarian estrogens play contributing roles. Furthermore, the timing of when...

journal_title：Neurobiology of aging

authors： Yin W,Borniger JC,Wang X,Maguire SM,Munselle ML,Bezner KS,Tesfamariam HM,Garcia AN,Hofmann HA,Nelson RJ,Gore AC

更新日期：2019-11-01 00:00:00

abstract：:Aging is associated with alterations in different systems that govern neuronal calcium homeostasis. This study was designed to determine whether any of these alterations may contribute to the decline in spatial working memory that is observed in old rats. Several parameters [initial (5 s) and steady state (15 min) 45C...

journal_title：Neurobiology of aging

authors： Huidobro A,Blanco P,Villalba M,Gómez-Puertas P,Villa A,Pereira R,Bogónez E,Martínez-Serrano A,Aparicio JJ,Satrústegui J

更新日期：1993-09-01 00:00:00

abstract：:Changes in regional cerebral blood flow (rCBF) associated with a face-matching task were examined using positron emission tomography (PET) and H2(15)O in 7 patients with mild-moderate dementia of the Alzheimer type (DAT) and in 8 healthy age-matched controls. rCBF was normalized to whole brain flow and pixel-by-pixel ...

journal_title：Neurobiology of aging

authors： Grady CL,Haxby JV,Horwitz B,Gillette J,Salerno JA,Gonzalez-Aviles A,Carson RE,Herscovitch P,Schapiro MB,Rapoport SI

更新日期：1993-01-01 00:00:00

abstract：:Evidence accumulates suggesting a complex interplay between neurodegenerative processes and serotonergic neurotransmission. We have previously reported an overexpression of serotonin 5-HT1A receptors (5-HT(1A)R) after intrahippocampal injections of amyloid-beta 1-40 (Aβ40) fibrils in rats. This serotonergic reactivity...

journal_title：Neurobiology of aging

authors： Verdurand M,Chauveau F,Daoust A,Morel AL,Bonnefoi F,Liger F,Bérod A,Zimmer L

更新日期：2016-04-01 00:00:00

abstract：:The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also propose...

journal_title：Neurobiology of aging

authors： Braae A,Medway C,Carrasquillo M,Younkin S,Alzheimer's Research UK (ARUK) Consortium.,Kehoe PG,Morgan K

更新日期：2015-04-01 00:00:00

abstract：:The total number of immunocytochemically identified vasopressin (AVP) cells was determined morphometrically in the paraventricular (PVN) and dorsolateral part of the supraoptic nucleus (dl-SON) of the human hypothalamus in 30 subjects ranging in age from 15 to 97 years, including 10 Alzheimer's disease (AD) patients. ...

journal_title：Neurobiology of aging

authors： Van der Woude PF,Goudsmit E,Wierda M,Purba JS,Hofman MA,Bogte H,Swaab DF

更新日期：1995-01-01 00:00:00

abstract：:Zen meditation, a Buddhist practice centered on attentional and postural self-regulation, has been speculated to bring about beneficial long-term effects for the individual, ranging from stress reduction to improvement of cognitive function. In this study, we examined how the regular practice of meditation may affect ...

journal_title：Neurobiology of aging

authors： Pagnoni G,Cekic M

更新日期：2007-10-01 00:00:00

abstract：:At early stages of Alzheimer's disease (AD), soluble amyloid beta (Aβ) accumulates in brain while microglia are in resting state. Microglia can recognize Aβ long after formation of plaques and release neurotoxic mediators. We examined impact of early minor activation of microglia by Toll-like receptors (TLRs) 2 and 4 ...

journal_title：Neurobiology of aging

authors： Pourbadie HG,Sayyah M,Khoshkholgh-Sima B,Choopani S,Nategh M,Motamedi F,Shokrgozar MA

更新日期：2018-10-01 00:00:00

abstract：:Mitochondrial dysfunction is likely a significant contributing factor to Alzheimer disease pathogenesis, and both amyloid peptide (Aβ) and pathological forms of tau may contribute to this impairment. Cleavage of tau at Asp421 occurs early in Alzheimer disease, and Asp421-cleaved tau likely negatively impacts neuronal ...

journal_title：Neurobiology of aging

authors： Quintanilla RA,Dolan PJ,Jin YN,Johnson GV

更新日期：2012-03-01 00:00:00

abstract：:Increasing evidence suggests that cholesterol plays a central role in the pathophysiology of Alzheimer's disease (AD). Caveolin is a cholesterol-binding membrane protein involved in cellular cholesterol transport. We investigated the changes in the protein amount of hippocampal caveolin of autopsy-confirmed AD and age...

journal_title：Neurobiology of aging

authors： Gaudreault SB,Dea D,Poirier J

更新日期：2004-07-01 00:00:00

abstract：:Abnormal neuronal excitability and impaired synaptic plasticity might occur before the degeneration and death of neurons in Alzheimer's disease (AD). To elucidate potential biophysical alterations underlying aberrant neuronal network activity in AD, we performed whole-cell patch clamp analyses of L-type (nifedipine-se...

journal_title：Neurobiology of aging

authors： Wang Y,Mattson MP

更新日期：2014-01-01 00:00:00

abstract：:Abberant lipid metabolism is implicated in Alzheimer's disease (AD) pathophysiology, but the connections between AD and lipid metabolic pathways are not fully understood. To investigate plasma lipids in AD, a multiplatform screen (n = 35 by liquid chromatography-mass spectrometry and n = 35 by nuclear magnetic resonan...

journal_title：Neurobiology of aging

authors： Whiley L,Sen A,Heaton J,Proitsi P,García-Gómez D,Leung R,Smith N,Thambisetty M,Kloszewska I,Mecocci P,Soininen H,Tsolaki M,Vellas B,Lovestone S,Legido-Quigley C,AddNeuroMed Consortium.

更新日期：2014-02-01 00:00:00