Abstract:
:Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated the estrogen-related receptor gamma (ESRRG) gene in determining adult hearing function and was investigated further in a total of 6134 individuals in 3 independent cohorts: (i) the 1958 British Birth Cohort; (ii) a London ARHL case-control cohort; and (iii) a cohort from isolated populations of Italy and Silk Road countries. Evidence of an association between the minor allele of single nucleotide polymorphism (SNP) rs2818964 and hearing status was found in females, but not in males in 2 of these cohorts: p = 0.0058 (London ARHL) and p = 0.0065 (Carlantino, Italy). Furthermore, assessment of hearing in Esrrg knock-out mice revealed a mild 25-dB hearing loss at 5 weeks of age. At 12 weeks, average hearing thresholds in female mice((-/-)) were 15 dB worse than in males((-/-)). Together these data indicate ESRRG plays a role in maintenance of hearing in both humans and mice.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Nolan LS,Maier H,Hermans-Borgmeyer I,Girotto G,Ecob R,Pirastu N,Cadge BA,Hübner C,Gasparini P,Strachan DP,Davis A,Dawson SJdoi
10.1016/j.neurobiolaging.2013.02.009subject
Has Abstractpub_date
2013-08-01 00:00:00pages
2077.e1-9issue
8eissn
0197-4580issn
1558-1497pii
S0197-4580(13)00082-1journal_volume
34pub_type
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