Regionally specific loss of neurons in the aging human hippocampus.

abstract：:Whole-exome sequencing recently identified a homozygous truncating mutation in Synaptojanin 1 (SYNJ1, PARK20), p.Arg258Gln, in 2 independent families with autosomal recessive young-onset parkinsonism with seizures and cognitive decline. This mutation's role in typical Parkinson's disease (PD) is unclear. We sequenced ...

journal_title：Neurobiology of aging

authors： Chen KH,Wu RM,Lin HI,Tai CH,Lin CH

更新日期：2015-10-01 00:00:00

abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...

journal_title：Neurobiology of aging

authors： Kaplan AS,Gash DM,Flood DG,Coleman PD

更新日期：1985-10-01 00:00:00

abstract：:Astrocytes and microglia from cerebral cortex of 3-, 6-, 12-, and 24-month-old F344 male rat donors showed progressively greater proliferation during primary culture. Microglia from aging donor brains exhibited an amoeboid-like morphology and express antigens characteristic of an activated state (e.g., major histocomp...

journal_title：Neurobiology of aging

authors： Rozovsky I,Finch CE,Morgan TE

更新日期：1998-01-01 00:00:00

abstract：:We previously found a selective loss of the brain specific APP-695 transcript in Alzheimer's disease (AD) cortex, which results in a 2.5-fold increase in the APP-751/APP-695 transcript ratio in AD (9). Here we report a similar increase in APP-751/APP-695 mRNA ratio in AD hippocampus. However, the cerebellum had a 6-fo...

journal_title：Neurobiology of aging

authors： Johnson SA,Rogers J,Finch CE

更新日期：1989-11-01 00:00:00

abstract：:Parkinson's disease (PD) and Alzheimer's dementia (AD) are often associated with an autonomic neuropathy. The extent of autonomic involvement, however is poorly defined and unpredictable. In order to assess the autonomic cardiovascular regulation baroreflex sensitivity (BRS) was determined non-invasively in 23 patient...

journal_title：Neurobiology of aging

authors： Szili-Török T,Kálmán J,Paprika D,Dibó G,Rózsa Z,Rudas L

更新日期：2001-05-01 00:00:00

abstract：:Cerebral gray-matter volume (GMV) decreases in normal aging but the extent of the decrease may be experience-dependent. Bilingualism may be one protective factor and in this article we examine its potential protective effect on GMV in a region that shows strong age-related decreases-the left anterior temporal pole. Th...

journal_title：Neurobiology of aging

authors： Abutalebi J,Canini M,Della Rosa PA,Sheung LP,Green DW,Weekes BS

更新日期：2014-09-01 00:00:00

abstract：:The goals were to investigate implicit learning in mild cognitive impairment (MCI), and to determine the relations of implicit learning systems to apolipoprotein E (ApoE) genotype in healthy controls. Elderly controls grouped by ApoE status (ApoE-e4 allele carriers versus ApoE-e4 allele non-carriers) and MCI patients ...

journal_title：Neurobiology of aging

authors： Negash S,Petersen LE,Geda YE,Knopman DS,Boeve BF,Smith GE,Ivnik RJ,Howard DV,Howard JH Jr,Petersen RC

更新日期：2007-06-01 00:00:00

abstract：:Pathologic expansion of the G4C2 repeat in C9orf72 is the main genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To evaluate the frequency of the G4C2 expansion in a Latin American cohort of FTD and ALS patients, we used a 2-step genotyping strategy. For FTD, we observed an overal...

journal_title：Neurobiology of aging

authors： Itzcovich T,Xi Z,Martinetto H,Chrem-Méndez P,Russo MJ,de Ambrosi B,Uchitel OD,Nogués M,Silva E,Rojas G,Bagnatti P,Amengual A,Campos J,Rogaeva E,St George-Hyslop P,Allegri R,Sevlever G,Surace EI

更新日期：2016-04-01 00:00:00

abstract：:The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition o...

journal_title：Neurobiology of aging

authors： Chen X,Hui L,Geiger NH,Haughey NJ,Geiger JD

更新日期：2013-10-01 00:00:00

abstract：:In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The aim of this study was to identify a particular immune profile in the peripheral blood (PB) and cerebrospinal fluid (CSF) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and its potential...

journal_title：Neurobiology of aging

authors： Lueg G,Gross CC,Lohmann H,Johnen A,Kemmling A,Deppe M,Groger J,Minnerup J,Wiendl H,Meuth SG,Duning T

更新日期：2015-01-01 00:00:00

abstract：:Plaques found in the brains of patients suffering from Alzheimer's disease (AD) mainly consist of beta-amyloid (Abeta), which is produced by sequential cleaving of amyloid precursor protein (APP) by two proteolytic enzymes, beta- and gamma-secretases. Any change in the fine balance between these enzymes and their subs...

journal_title：Neurobiology of aging

authors： Zohar O,Pick CG,Cavallaro S,Chapman J,Katzav A,Milman A,Alkon DL

更新日期：2005-08-01 00:00:00

abstract：:Aggregates of hyperphosphorylated tau protein are a pathological hallmark of Alzheimer's disease (AD). The origin of AD is multifactorial, and many metabolic disorders originating from overconsumption of fat, cholesterol, and sugar are associated with higher risk of AD later in life. However, the effects of fat, chole...

journal_title：Neurobiology of aging

authors： Gratuze M,Julien J,Morin F,Calon F,Hébert SS,Marette A,Planel E

更新日期：2016-11-01 00:00:00

abstract：:It was previously reported that in soleus neuromuscular junctions of old mice, synaptic vesicle density was decreased while transmitter release was increased (compared to results in young mice). In the present study, two hypotheses that might resolve this disparity were tested. The first was that the density of readil...

journal_title：Neurobiology of aging

authors： Fahim MA,Robbins N,Price R

更新日期：1987-01-01 00:00:00

abstract：:Brain injury increases the risk of Alzheimer's disease (AD) through unknown mechanisms. We studied deposition of amyloid-beta protein (Abeta) in cells exposed to transforming growth factor beta1 (TGFbeta1), a cytokine that regulates cell metabolism during brain injury, and apolipoproteinE (apoE), the major lipid trans...

journal_title：Neurobiology of aging

authors： Mazur-Kolecka B,Frackowiak J,Le Vine H 3rd,Haske T,Evans L,Sukontasup T,Golabek A

更新日期：2003-03-01 00:00:00

abstract：:Type 2 diabetes mellitus is a risk factor of Alzheimer's disease (AD), most likely linked to an impairment of insulin signaling in the brain. Liraglutide, a novel long-lasting glucagon-like peptide 1 (GLP-1) analog, facilitates insulin signaling and shows neuroprotective properties. In the present study, we analyzed t...

journal_title：Neurobiology of aging

authors： Han WN,Hölscher C,Yuan L,Yang W,Wang XH,Wu MN,Qi JS

更新日期：2013-02-01 00:00:00

abstract：:Recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the Kunitz protease inhibitor (KPI) domain of beta-amyloid precursor protein (APP), thereby facilitating deposition of abnormal amyloid filaments in patients with ...

journal_title：Neurobiology of aging

authors： DeFeudis FV

更新日期：1989-09-01 00:00:00

abstract：:Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia. Here we report the establishment and characterization of a novel knockin (KI) rat model expressing a Fus point mutation (R521C) via CRISPR/Cas9. The mutant animals developed adult-onset lear...

journal_title：Neurobiology of aging

authors： Zhang T,Jiang X,Xu M,Wang H,Sang X,Qin M,Bao P,Wang R,Zhang C,Lu H,Li Y,Ren J,Chang HC,Yan J,Sun Q,Xu J

更新日期：2018-12-01 00:00:00

abstract：:Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. ...

journal_title：Neurobiology of aging

authors： Knopman DS,Jack CR Jr,Wiste HJ,Lundt ES,Weigand SD,Vemuri P,Lowe VJ,Kantarci K,Gunter JL,Senjem ML,Mielke MM,Roberts RO,Boeve BF,Petersen RC

更新日期：2014-09-01 00:00:00

abstract：:The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to...

journal_title：Neurobiology of aging

authors： Larsson M,Hedner M,Papenberg G,Seubert J,Bäckman L,Laukka EJ

更新日期：2016-02-01 00:00:00

abstract：:The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly c...

journal_title：Neurobiology of aging

authors： Sullivan EV,Marsh L,Mathalon DH,Lim KO,Pfefferbaum A

更新日期：1995-07-01 00:00:00

abstract：:Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysi...

journal_title：Neurobiology of aging

authors： Zuo X,Zhuang J,Chen NK,Cousins S,Cunha P,Lad EM,Madden DJ,Potter G,Whitson HE

更新日期：2020-11-01 00:00:00

abstract：:While resting, Fischer-344 rats underwent a decrease in heart rate and an increase in diastolic blood pressure and plasma norepinephrine with increasing age. The blood pressure of adult rats increased significantly during a 3 minute immobilization. The blood pressure of old rats failed to increase during stress, decre...

journal_title：Neurobiology of aging

authors： Chiueh CC,Nespor SM,Rapoport SI

更新日期：1980-01-01 00:00:00

abstract：:Astrocytes play a crucial role in supporting motor neurons in health and disease. However, there have been few attempts to understand how aging may influence this effect. Here, we report that rat astrocytes show an age-dependent senescence phenotype and a significant reduction in their ability to support motor neurons...

journal_title：Neurobiology of aging

authors： Das MM,Svendsen CN

更新日期：2015-02-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation technique, has emerged as a promising treatment for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, however, the effectiveness of this therapy is unclear because of the low statistical power and heterogeneity ...

journal_title：Neurobiology of aging

authors： Chou YH,Ton That V,Sundman M

更新日期：2020-02-01 00:00:00

abstract：:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal...

journal_title：Neurobiology of aging

authors： May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

更新日期：1992-09-01 00:00:00

abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

journal_title：Neurobiology of aging

authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

更新日期：2008-12-01 00:00:00

abstract：:The accumulation of β-amyloid (Aβ) peptide derived from abnormal processing of amyloid precursor protein (APP) is a common pathological hallmark of Alzheimer's disease (AD) brains. In this study, we evaluated the therapeutic effect of berberine (BBR) extracted from Coptis chinensis Franch, a Chinese medicinal herb, on...

journal_title：Neurobiology of aging

authors： Durairajan SS,Liu LF,Lu JH,Chen LL,Yuan Q,Chung SK,Huang L,Li XS,Huang JD,Li M

更新日期：2012-12-01 00:00:00

abstract：:Alzheimer disease (AD) is characterised by a decrease of platelet Amyloid Precursor Protein forms ratio (APPr), which parallels symptoms' severity. Recent studies have suggested that cholesterol might play a role in the pathophysiology of AD by modulating Abeta production. Aim of this study was to evaluate the relatio...

journal_title：Neurobiology of aging

authors： Borroni B,Colciaghi F,Lenzi GL,Caimi L,Cattabeni F,Di Luca M,Padovani A

更新日期：2003-09-01 00:00:00

abstract：:One major pathological process in Alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (MTs) and functions associated with tau. A potential way to compensate for altered MT function is to use an MT stabilizer, such as epothilone D (EpoD). Previous studies have demonstrated im...

journal_title：Neurobiology of aging

authors： Guo B,Huang Y,Gao Q,Zhou Q

更新日期：2020-12-01 00:00:00

abstract：:Genome-wide association studies have associated clusterin (CLU) variants with Alzheimer's disease (AD). However, the role of CLU on AD pathogenesis is not totally understood. We used cerebrospinal fluid (CSF) and plasma CLU levels as endophenotypes for genetic studies to understand the role of CLU in AD. CSF, but not ...

journal_title：Neurobiology of aging

authors： Deming Y,Xia J,Cai Y,Lord J,Holmans P,Bertelsen S,Holtzman D,Morris JC,Bales K,Pickering EH,Kauwe J,Goate A,Cruchaga C,Alzheimer's Disease Neuroimaging Initiative (ADNI).

更新日期：2016-01-01 00:00:00