Abstract:
:Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS. We aimed to elucidate the role of previously published and novel exonic indels in FUS in an extensive cohort of 630 ALS patients and 1063 controls. We detected indels in FUS exons 5, 6, 12, and 14 with similar frequencies in patients (0.95%) and controls (0.75%). Exonic indels in poly glycine tracts were also observed with similar frequencies. The largest indel (p.Gly138_Tyr143del) was observed in 1 control. In 1 patient, a 3 base pair deletion in exon 14 (p.Gly475del) was identified, however in vitro studies did not reveal abnormal localization of p.Gly475del mutant FUS. These findings suggest that not all exonic indels in FUS cause disease.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Rutherford NJ,Finch NA,DeJesus-Hernandez M,Crook RJ,Lomen-Hoerth C,Wszolek ZK,Uitti RJ,Graff-Radford NR,Rademakers Rdoi
10.1016/j.neurobiolaging.2010.09.029subject
Has Abstractpub_date
2012-02-01 00:00:00pages
424.e23-4issue
2eissn
0197-4580issn
1558-1497pii
S0197-4580(10)00423-9journal_volume
33pub_type
杂志文章abstract::Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amylo...
journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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更新日期:1995-01-01 00:00:00
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Neurobiology of aging
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