当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > II. Temporal patterns of longitudinal change in aging brain function.

II. Temporal patterns of longitudinal change in aging brain function.

Abstract：

:Time-dependent changes in brain activity were assessed in a group of older adults who maintained good physical and cognitive health at years 1, 3, 5, 7, and 9 of the Baltimore Longitudinal Study of Aging neuroimaging study. Each year, these participants underwent PET scans during rest and delayed verbal and figural recognition memory conditions. While memory performance remained stable over the 8 years, both generalized and modality-specific patterns of time-dependent changes in regional cerebral blood flow (rCBF) were found. Many brain regions showed steady, progressive changes in rCBF over the 8 years while others maintained rCBF for a number of years before showing incremental declines or increases in activity. These temporal patterns of change were observed in many regions of the brain, particularly in the frontal and temporal lobes, suggesting that there are distinctive patterns of age-related functional decline and compensatory activity over time. The precise patterns of regional involvement and the temporal dynamics of rCBF change within specific regions vary based on cognitive processing demands.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Beason-Held LL,Kraut MA,Resnick SM

doi

10.1016/j.neurobiolaging.2006.11.011

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

497-513

issue

4

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(06)00431-3

journal_volume

29

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice.

    abstract：:Extracellular deposit of amyloid beta (Aβ) is a common pathologic feature in both age-related macular degeneration (AMD) and Alzheimer's disease, but the role of intracellular Aβ on the tight junction of the retinal pigment epithelium (RPE) is unknown. In this study, we investigated the intracellular Aβ expression and...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.03.008

    authors： Park SW,Kim JH,Mook-Jung I,Kim KW,Park WJ,Park KH,Kim JH

    更新日期：2014-09-01 00:00:00

  • A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease.

    abstract：:Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells activate the unfolded protein response (UPR), a signal transduction pathway that enforces adaptive p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2017.09.012

    authors： Gerakis Y,Hetz C

    更新日期：2018-03-01 00:00:00

  • beta-Amyloid peptide in vitro toxicity: lot-to-lot variability.

    abstract：:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90064-5

    authors： May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

    更新日期：1992-09-01 00:00:00

  • Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.

    abstract：:Elevated serum and cerebrospinal fluid concentrations of S100β, a protein predominantly found in glia, are associated with intracranial injury and neurodegeneration, although concentrations are also influenced by several other factors. The longitudinal association between serum S100β concentrations and brain health in...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.05.029

    authors： Cox SR,Allerhand M,Ritchie SJ,Muñoz Maniega S,Valdés Hernández M,Harris SE,Dickie DA,Anblagan D,Aribisala BS,Morris Z,Sherwood R,Abbott NJ,Starr JM,Bastin ME,Wardlaw JM,Deary IJ

    更新日期：2018-09-01 00:00:00

  • Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE.

    abstract：:Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or "cognitive phenotype" is variable. The apolipoprotein E ε4 (APOE ε4) allele has been associated with an amnestic presentation, but does not appear to fully expla...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.11.003

    authors： Vardy ER,Brown K,Stopford CL,Thompson JC,Richardson AM,Neary D,Kalsheker N,Morgan K,Mann DM,Snowden JS

    更新日期：2012-07-01 00:00:00

  • Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity.

    abstract：:Amyloid beta (Aβ) deposition and cognitive decline are key features of Alzheimer's disease. The relationship between Aβ status and changes in neuronal function over time, however, remains unclear. We evaluated the effect of baseline Aβ status on reference region spontaneous brain activity (SBA-rr) using resting-state ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.10.002

    authors： Avants BB,Hutchison RM,Mikulskis A,Salinas-Valenzuela C,Hargreaves R,Beaver J,Chiao P,Alzheimer's Disease Neuroimaging Initiative.

    更新日期：2019-02-01 00:00:00

  • Age-related vulnerability of pattern separation in C57BL/6J mice.

    abstract：:Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.10.013

    authors： Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

    更新日期：2018-02-01 00:00:00

  • Age-related differences in the topological efficiency of the brain structural connectome in amnestic mild cognitive impairment.

    abstract：:Amnestic mild cognitive impairment (aMCI) is accompanied by the accelerated cognitive decline and rapid brain degeneration with aging. However, the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown. In this study, we constructed the brain structur...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.08.005

    authors： Zhao T,Sheng C,Bi Q,Niu W,Shu N,Han Y

    更新日期：2017-11-01 00:00:00

  • Genetic analysis of LRRK2 in Parkinson's disease in Han Chinese population.

    abstract：:Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent genetic factors contributing to Parkinson's disease (PD). The aim of our study was to explore LRRK2 variants in PD patients within the mainland Han Chinese population. The whole coding regions of LRRK2 from 296 PD patients were seque...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.06.036

    authors： Zhang JR,Jin H,Li K,Mao CJ,Yang YP,Wang F,Gu CC,Zhang HJ,Chen J,Liu CF

    更新日期：2018-12-01 00:00:00

  • Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects.

    abstract：:The aim of this study is to investigate the relationship between aging and brain vasculature health. Three groups of mice, 3, 17-18, and 24 months, comparable to young adult, middle age, and old human were studied. Prussian blue histology and fast imaging with steady precession T2∗-weighted magnetic resonance imaging ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.11.017

    authors： Wang Y,Taylor E,Zikopoulos B,Seta F,Huang N,Hamilton JA,Kantak KM,Morgan KG

    更新日期：2020-12-09 00:00:00

  • Heterozygous TYROBP deletion (PLOSLFIN) is not a strong risk factor for cognitive impairment.

    abstract：:Biallelic loss-of-function mutations in TYROBP and TREM2 cause a rare disease that resembles early-onset frontotemporal dementia with bone lesions called polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Some PLOSL-causing variants in TREM2 have also been associated with Alzheimer's...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.12.008

    authors： Kaivola K,Jansson L,Saarentaus E,Kiviharju A,Rantalainen V,Eriksson JG,Strandberg TE,Polvikoski T,Myllykangas L,Tienari PJ

    更新日期：2018-04-01 00:00:00

  • The pituitary-adrenal response to novel stimulation and ether stress in young adult and aged rats.

    abstract：:Pituitary-adrenal responsiveness to stress induced by either psychological (novelty) or physiological (ether) stimuli was examined in young (3 to 6 months) and old (24 to 27 months) male and female rats. In Experiment 1, subjects were placed in a novel environment for 3 min. Blood samples were collected at 0, 15, 30, ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(83)90037-4

    authors： Brett LP,Chong GS,Coyle S,Levine S

    更新日期：1983-07-01 00:00:00

  • Aging elevates metabolic gene expression in brain cholinergic neurons.

    abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.04.024

    authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

    更新日期：2008-12-01 00:00:00

  • Associations of carotid arterial compliance and white matter diffusion metrics during midlife: modulation by sex.

    abstract：:Sex differences in cerebral white matter (WM) aging have been debated extensively over the past 2 decades without unequivocal resolution. We aimed to determine if the effects of age and arterial stiffness on WM microstructure differ between sexes. Artery elasticity via carotid artery compliance (CAC) and WM diffusion ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.02.012

    authors： Pasha EP,Birdsill AC,Oleson S,Tanaka H,Haley AP

    更新日期：2018-06-01 00:00:00

  • Hippocampal hypometabolism predicts cognitive decline from normal aging.

    abstract：OBJECTIVE:This longitudinal study used FDG-PET imaging to predict and monitor cognitive decline from normal aging. METHODS:Seventy-seven 50-80-year-old normal (NL) elderly received longitudinal clinical examinations over 6-14 years (561 person-years, mean per person 7.2 years). All subjects had a baseline FDG-PET scan...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.12.008

    authors： Mosconi L,De Santi S,Li J,Tsui WH,Li Y,Boppana M,Laska E,Rusinek H,de Leon MJ

    更新日期：2008-05-01 00:00:00

  • The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment.

    abstract：:The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant. We examined the influence of TOMM40 "523" polymorphism on spatial navigation and its brain s...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2015.03.004

    authors： Laczó J,Andel R,Vyhnalek M,Matoska V,Kaplan V,Nedelska Z,Lerch O,Gazova I,Moffat SD,Hort J

    更新日期：2015-06-01 00:00:00

  • Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model.

    abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.07.014

    authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

    更新日期：2014-01-01 00:00:00

  • Rare and common variants in the Apolipoprotein E gene in healthy oldest old.

    abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.09.010

    authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

    更新日期：2014-03-01 00:00:00

  • Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.

    abstract：:Alzheimer's disease (AD) is characterized by a progressive cognitive decline leading to dementia and involves the deposition of amyloid-beta (Abeta) peptides into senile plaques. Other neuropathological features that accompany progression of the disease include a decrease in synaptic density, neurofibrillary tangles, ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2003.08.008

    authors： Dudal S,Krzywkowski P,Paquette J,Morissette C,Lacombe D,Tremblay P,Gervais F

    更新日期：2004-08-01 00:00:00

  • Motor function in young and aged hemiplegic rats: effects of a Ginkgo biloba extract.

    abstract：:We have previously shown beneficial effects of a Ginkgo biloba extract (EGb761-IPSEN) in accelerating functional recovery from hemiplegia induced by unilateral motor cortex ablation. Here, we report the behavioral and histological effects of various dose regimes of EGb761. In young rats (3 months), 10 mg/kg/day for 7 ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00007-9

    authors： Brailowsky S,Montiel T

    更新日期：1997-03-01 00:00:00

  • A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

    abstract：:A major goal of animal research is to identify interventions that can promote successful aging and delay or reverse age-related cognitive decline in humans. Recent advances in standardizing cognitive assessment tools for humans have the potential to bring preclinical work closer to human research in aging and Alzheime...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2013.01.018

    authors： Snigdha S,Milgram NW,Willis SL,Albert M,Weintraub S,Fortin NJ,Cotman CW

    更新日期：2013-07-01 00:00:00

  • Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease.

    abstract：:Discovered in the brains of multiple animal species, piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease (AD). Prefrontal cortical tissues of 6 AD cases and 6 controls were examined f...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.05.020

    authors： Qiu W,Guo X,Lin X,Yang Q,Zhang W,Zhang Y,Zuo L,Zhu Y,Li CR,Ma C,Luo X

    更新日期：2017-09-01 00:00:00

  • Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

    abstract：:An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.09.030

    authors： Solé M,Miñano-Molina AJ,Unzeta M

    更新日期：2015-02-01 00:00:00

  • Longitudinal assessment of default-mode brain function in aging.

    abstract：:Age-related changes in the default-mode network (DMN) have been identified in prior cross-sectional functional magnetic resonance imaging studies. Here, we investigated longitudinal change in DMN activity and connectivity. Cognitively intact participants (aged 49-79 years at baseline) were scanned twice, with a 6-year...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.03.012

    authors： Persson J,Pudas S,Nilsson LG,Nyberg L

    更新日期：2014-09-01 00:00:00

  • Infiltration of the brain by pathogens causes Alzheimer's disease.

    abstract：:Despite very numerous studies on Alzheimer's disease (AD), especially on amyloid plaques and neurofibrillary tangles, little information has been obtained thus on the causes of the disease. Evidence is described here that implicates firstly herpes simplex virus type 1 (HSV1) as a strong risk factor when it is present ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2003.12.021

    authors： Itzhaki RF,Wozniak MA,Appelt DM,Balin BJ

    更新日期：2004-05-01 00:00:00

  • Genetic analysis of CHCHD2 and CHCHD10 in Italian patients with Parkinson's disease.

    abstract：:In recent years, CHCHD2 and CHCHD10 mutations were reported to be associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), although with conflicting results in different populations. The present study aimed to evaluate CHCHD2 and CHCHD10 coding variants in Italian patients wi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.12.027

    authors： Rubino E,Brusa L,Zhang M,Boschi S,Govone F,Vacca A,Gai A,Pinessi L,Lopiano L,Rogaeva E,Rainero I

    更新日期：2017-05-01 00:00:00

  • Up-regulation of opiate receptors following chronic naloxone treatment in aged rats.

    abstract：:The present study assessed whether there are age-dependent differences in up-regulation of opiate receptors following chronic naloxone treatment in mature (3 months) and aged (27 months) male Wistar rats. Half of each age group were implanted subdermally with slow-release naloxone pellets for 10 days, and half were gi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(89)80011-9

    authors： Neisewander JL,Nonneman AJ,McDougall SA,Bardo MT

    更新日期：1989-01-01 00:00:00

  • Effects of aging on learned suppression of photopositive tendencies in Drosophila melanogaster.

    abstract：:The effect of aging on acquisition of a learned suppression of photopositive tendencies was studied in 1-7-week-old flies of both sexes. Flies had to choose in a T-maze between an alley leading to a lighted vial associated with an aversive stimulus, a quinine hydrochloride solution, and another alley leading to a dark...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2003.12.004

    authors： Le Bourg E

    更新日期：2004-10-01 00:00:00

  • Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.

    abstract：:Mild cognitive impairment (MCI) represents a heterogeneous group of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (1H MRS), of modifications in b...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2005.05.002

    authors： Metastasio A,Rinaldi P,Tarducci R,Mariani E,Feliziani FT,Cherubini A,Pelliccioli GP,Gobbi G,Senin U,Mecocci P

    更新日期：2006-07-01 00:00:00

  • Early development of social deficits in APP and APP-PS1 mice.

    abstract：:Mimicking relevant behavioral features of the human pathology is one of the most important challenges for animal models of neurological disorders including Alzheimer disease (AD). Indeed, the most popular genetic AD mouse lines bearing mutations of the amyloid precursor protein (APP) and presenilin 1 genes (PS1), ofte...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.09.012

    authors： Pietropaolo S,Delage P,Lebreton F,Crusio WE,Cho YH

    更新日期：2012-05-01 00:00:00