Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy.

abstract：:Alzheimer's disease (AD) and age-related macular degeneration (AMD) are both neurodegenerative disorders which share common pathological and biochemical features of the complement pathway. The aim of this study was to investigate whether there is an association between well replicated AMD genetic risk factors and AD. ...

journal_title：Neurobiology of aging

authors： Proitsi P,Lupton MK,Dudbridge F,Tsolaki M,Hamilton G,Daniilidou M,Pritchard M,Lord K,Martin BM,Johnson J,Craig D,Todd S,McGuinness B,Hollingworth P,Harold D,Kloszewska I,Soininen H,Mecocci P,Velas B,Gill M,Lawlor

更新日期：2012-08-01 00:00:00

abstract：:The effect of normal aging on the volume of the hippocampus and temporal cortex was assessed cross-sectionally with quantitative Magnetic Resonance Imaging (MRI) in 72 healthy men, spanning 5 decades of the adult age range (21 to 70 years). Neither the hippocampal nor cortical white matter volumes were significantly c...

journal_title：Neurobiology of aging

authors： Sullivan EV,Marsh L,Mathalon DH,Lim KO,Pfefferbaum A

更新日期：1995-07-01 00:00:00

abstract：:Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat hippocampus. Aβ 1-42 was injected bilaterally to the hippocampus CA1 region of adult male...

journal_title：Neurobiology of aging

authors： Lu Y,Wang R,Dong Y,Tucker D,Zhao N,Ahmed ME,Zhu L,Liu TC,Cohen RM,Zhang Q

更新日期：2017-01-01 00:00:00

abstract：:The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition o...

journal_title：Neurobiology of aging

authors： Chen X,Hui L,Geiger NH,Haughey NJ,Geiger JD

更新日期：2013-10-01 00:00:00

abstract：:Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been foun...

journal_title：Neurobiology of aging

authors： Siitonen A,Nalls MA,Hernández D,Gibbs JR,Ding J,Ylikotila P,Edsall C,Singleton A,Majamaa K

更新日期：2017-05-01 00:00:00

abstract：:Pertinent animal models of age-related learning deficiencies are required to elucidate the mechanism of age-related learning deficiencies and to develop novel therapeutic drugs for age-related diseases such as learning defects. Among many strains of accelerated senescence prone, senescence-accelerated mouse (SAM), SAM...

journal_title：Neurobiology of aging

authors： Nomura Y,Okuma Y

更新日期：1999-03-01 00:00:00

abstract：:Aged rats exhibit an impaired ability to sustain long-term potentiation in dentate gyrus which correlates with a decrease in arachidonic acid concentration. Here we confirm the previous finding that dietary supplementation with arachidonic acid and its precursor, gamma-linolenic acid, reversed the impairment in LTP in...

journal_title：Neurobiology of aging

authors： McGahon BM,Murray CA,Horrobin DF,Lynch

更新日期：1999-11-01 00:00:00

abstract：:A variety of studies have shown an effect of estrogen on dopamine function and suggest that estrogen may modulate central dopaminergic activity. Positron emission tomography (PET) and the dopamine metabolism tracer, [18F]6-fluoro-L-m-tyrosine (FMT) were used to evaluate dopaminergic function in the frontal cortex and ...

journal_title：Neurobiology of aging

authors： Eberling JL,Roberts JA,Taylor SE,VanBrocklin HF,O'Neil JP,Nordahl TE

更新日期：2002-05-01 00:00:00

abstract：:Multiple degenerative hallmarks characterize Alzheimer's disease: insoluble protein deposition, neuronal loss and cortical atrophy. Atrophy begins in the medial temporal lobe and becomes global by end stage. In a small proportion of cases, these tissue changes are caused by mutations in three known genes. These cases ...

journal_title：Neurobiology of aging

authors： Gregory GC,Macdonald V,Schofield PR,Kril JJ,Halliday GM

更新日期：2006-03-01 00:00:00

abstract：:Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases. Besides their social implications, the different forms of dementia, including Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies or frontotemporal dementia, sh...

journal_title：Neurobiology of aging

authors： Gámez-Valero A,Beyer K,Borràs FE

更新日期：2019-02-01 00:00:00

abstract：:Compared to young rats, old age increases susceptibility and caloric restriction decreases susceptibility for the loss of retinal ganglion cells and displaced amacrine cells following retinal ischemia/reperfusion. In retinas of old animals before ischemia, reactive gliosis, including activation of Muller cells, microg...

journal_title：Neurobiology of aging

authors： Kim KY,Ju WK,Neufeld AH

更新日期：2004-04-01 00:00:00

abstract：:In recent years, CHCHD2 and CHCHD10 mutations were reported to be associated with a broad spectrum of neurodegenerative diseases, including Parkinson's disease (PD), although with conflicting results in different populations. The present study aimed to evaluate CHCHD2 and CHCHD10 coding variants in Italian patients wi...

journal_title：Neurobiology of aging

authors： Rubino E,Brusa L,Zhang M,Boschi S,Govone F,Vacca A,Gai A,Pinessi L,Lopiano L,Rogaeva E,Rainero I

更新日期：2017-05-01 00:00:00

abstract：:In these experiments, potential cognitive deficits in aged rats were studied using an odor-reward association task. Aged Fischer 344 rats first performed to an odor-reward association task. After five daily sessions of 60 trials, the aged rats were globally impaired in comparison to the control rats. However, consider...

journal_title：Neurobiology of aging

authors： Roman FS,Alescio-Lautier B,Soumireu-Mourat B

更新日期：1996-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease) is a progressive debilitating neurodegenerative disease with no cure. We propose a novel molecular model for the pathogenesis of ALS that involves an adenosine triphosphate (ATP)-dependent muscle neuronal lactate shuttle (MNLS) at the neuromuscular junction (NM...

journal_title：Neurobiology of aging

authors： Vadakkadath Meethal S,Atwood CS

更新日期：2012-03-01 00:00:00

abstract：:To identify genes associated with frontotemporal dementia (FTD) in South-East Asia, targeted exome sequencing and C9orf72 genotyping was performed in 198 subjects (52 patients with FTD and 146 healthy controls) who were screened for mutations in 12 FTD-associated genes. We detected a homozygous TREM2 R47C mutation in ...

journal_title：Neurobiology of aging

authors： Ng ASL,Tan YJ,Yi Z,Tandiono M,Chew E,Dominguez J,Macas M,Ng E,Hameed S,Ting S,Tan EK,Foo JN,Kandiah N

更新日期：2018-08-01 00:00:00

abstract：:Abberant lipid metabolism is implicated in Alzheimer's disease (AD) pathophysiology, but the connections between AD and lipid metabolic pathways are not fully understood. To investigate plasma lipids in AD, a multiplatform screen (n = 35 by liquid chromatography-mass spectrometry and n = 35 by nuclear magnetic resonan...

journal_title：Neurobiology of aging

authors： Whiley L,Sen A,Heaton J,Proitsi P,García-Gómez D,Leung R,Smith N,Thambisetty M,Kloszewska I,Mecocci P,Soininen H,Tsolaki M,Vellas B,Lovestone S,Legido-Quigley C,AddNeuroMed Consortium.

更新日期：2014-02-01 00:00:00

abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease have not yet been clarified, and it is not known whether there is a critical period. Estrogen induced significant protection against 6-hydroxydopamine-induced dopaminergic degeneration when administered immediately or 6 weeks, but not 20...

journal_title：Neurobiology of aging

authors： Rodriguez-Perez AI,Borrajo A,Valenzuela R,Lanciego JL,Labandeira-Garcia JL

更新日期：2015-02-01 00:00:00

abstract：:Astrocytes and microglia from cerebral cortex of 3-, 6-, 12-, and 24-month-old F344 male rat donors showed progressively greater proliferation during primary culture. Microglia from aging donor brains exhibited an amoeboid-like morphology and express antigens characteristic of an activated state (e.g., major histocomp...

journal_title：Neurobiology of aging

authors： Rozovsky I,Finch CE,Morgan TE

更新日期：1998-01-01 00:00:00

abstract：:The impact of many inflammatory diseases is influenced by age-related changes in the activation of resident and circulating myeloid cells. In the eye, a major sight-threatening consequence of age-related macular degeneration is the development of severe choroidal neovascularization (CNV). To identify the molecular pat...

journal_title：Neurobiology of aging

authors： Robbie SJ,Georgiadis A,Barker SE,Duran Y,Smith AJ,Ali RR,Luhmann UFO,Bainbridge JW

更新日期：2016-04-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Eight elderly subjects (aged 68-95 years) and 6 young adults (aged 21-24 years) performed elbow flexion and extension movements in a visual step-tracking paradigm. Movement amplitudes ranging from 10 degrees-80 degrees were made under two instructions: "move at own speed" and "move fast and accurate." In a second expe...

journal_title：Neurobiology of aging

authors： Darling WG,Cooke JD,Brown SH

更新日期：1989-03-01 00:00:00

abstract：:The hippocampal perforant pathway originates in the entorhinal cortex (ERC) and terminates in the outer molecular layer of the dentate gyrus (DG). To compare the effects of normal aging and Alzheimer's disease (AD) on the elements of the perforant pathway, we compared relative perikaryal numbers (determined by countin...

journal_title：Neurobiology of aging

authors： Lippa CF,Hamos JE,Pulaski-Salo D,DeGennaro LJ,Drachman DA

更新日期：1992-05-01 00:00:00

abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

journal_title：Neurobiology of aging

authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

更新日期：2015-01-01 00:00:00

abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

journal_title：Neurobiology of aging

authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

更新日期：2014-03-01 00:00:00

abstract：:The Tachykinin Receptor 2 (TACR2) located at chromosome 10q21.3 belongs to a class of receptors that bind members of the tachykinin neurotransmitter family. The TACR2 binds neurokinin A, also known as substance K, and is expressed in distinct parts of the human brain. Functionally, the TACR2 has been implicated in str...

journal_title：Neurobiology of aging

authors： Friedrich P,Feulner TM,Laws SM,Eckart K,Perneczky R,Kurz A,Förstl H,Riemenschneider M

更新日期：2011-03-01 00:00:00

abstract：:Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean a...

journal_title：Neurobiology of aging

authors： Flöel A,Suttorp W,Kohl O,Kürten J,Lohmann H,Breitenstein C,Knecht S

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Aging is a major risk factor for a variety of neurobiological diseases leading to variations of transcriptional expression in affected tissues. Reverse transcription of RNA followed by quantitative PCR is a powerful technique for detection and quantification of specific transcripts differentially expressed. ...

journal_title：Neurobiology of aging

authors： Sieber MW,Guenther M,Kohl M,Witte OW,Claus RA,Frahm C

更新日期：2010-04-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are ubiquitously present within the perivascular basement membrane, and have been shown to be altered in patients with Alzheimer's Disease (AD). Although the HSPG agrin clearly orchestrates the differentiation of the neuromuscular junction, its role in the brain remains unclear. G...

journal_title：Neurobiology of aging

authors： Berzin TM,Zipser BD,Rafii MS,Kuo-Leblanc V,Yancopoulos GD,Glass DJ,Fallon JR,Stopa EG

更新日期：2000-03-01 00:00:00

abstract：:Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like...

journal_title：Neurobiology of aging

authors： Zheng H,Liu CC,Atagi Y,Chen XF,Jia L,Yang L,He W,Zhang X,Kang SS,Rosenberry TL,Fryer JD,Zhang YW,Xu H,Bu G

更新日期：2016-06-01 00:00:00

abstract：:Chronic circadian disturbance, a condition of desynchronization between endogenous clock and environmental light-dark (LD) cycle, is known to cause adverse physiological changes including mortality. However, it is yet unclear whether these consequences result from disturbance of endogenous clock or condition of the LD...

journal_title：Neurobiology of aging

authors： Park N,Cheon S,Son GH,Cho S,Kim K

更新日期：2012-06-01 00:00:00