Age-related vulnerability of pattern separation in C57BL/6J mice.

Abstract:

:Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS performance. The present study investigated the effect of aging in C57BL/6J mice performing PS tasks based on either object features or object location. At the age of 18 months or more, performance was severely impaired in both tasks. Spatial PS performance declined gradually over adult lifespan from 3 to 21 months. Subchronic treatment with the cognitive enhancer D-serine fully rescued spatial PS performance in 18-month-old mice and induced a modest increase in the number of 4-week-old adult-born cells in the DG. Performance of mice in these PS tasks shows an age dependence, which appears to translate well to that found in humans. This model should help in deciphering physiological changes underlying PS deficits and in identifying future therapeutic targets.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

doi

10.1016/j.neurobiolaging.2017.10.013

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

120-129

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(17)30352-4

journal_volume

62

pub_type

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