当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Age-related differences in the topological efficiency of the brain structural connectome in amnestic mild cognitive impairment.

Age-related differences in the topological efficiency of the brain structural connectome in amnestic mild cognitive impairment.

Abstract：

:Amnestic mild cognitive impairment (aMCI) is accompanied by the accelerated cognitive decline and rapid brain degeneration with aging. However, the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown. In this study, we constructed the brain structural connectome in 51 aMCI patients and 51 healthy controls by diffusion magnetic resonance imaging and deterministic tractography. The different age-related alteration patterns of the global and regional network metrics between aMCI patients and healthy controls were assessed by a linear regression model. Compared with healthy controls, significantly decreased global and local network efficiency in aMCI patients were found. When correlating network efficiency with age, we observed a significant decline in network efficiency with aging in the aMCI patients, while not in the healthy controls. The age-related decreases of nodal efficiency in aMCI patients were mainly distributed in the key regions of the default-mode network, such as precuneus, anterior cingulate gyrus, and parahippocampal gyrus. In addition, age-related decreases in the connection strength of the edges between peripheral nodes were observed in aMCI patients. Moreover, the decreased regional efficiency of the parahippocampal gyrus was correlated with impaired memory performances in patients. The present study suggests an age-related disruption of the topological organization of the brain structural connectome in aMCI patients, which may provide evidence for different neural mechanisms underlying aging in aMCI and may serve as a potential imaging marker for the early diagnosis of Alzheimer's disease.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Zhao T,Sheng C,Bi Q,Niu W,Shu N,Han Y

doi

10.1016/j.neurobiolaging.2017.08.005

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

144-155

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(17)30260-9

journal_volume

59

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging.

    abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00034-1

    authors： Ohm TG,Busch C,Bohl J

    更新日期：1997-07-01 00:00:00

  • Age-related vulnerability of pattern separation in C57BL/6J mice.

    abstract：:Aging is associated with impaired performance in behavioral pattern separation (PS) tasks based on similarities in object features and in object location. These deficits have been attributed to functional alterations in the dentate gyrus (DG)-CA3 region. Animal studies suggested a role of adult-born DG neurons in PS p...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.10.013

    authors： Cès A,Burg T,Herbeaux K,Héraud C,Bott JB,Mensah-Nyagan AG,Mathis C

    更新日期：2018-02-01 00:00:00

  • Rare and common variants in the Apolipoprotein E gene in healthy oldest old.

    abstract：:Apolipoprotein E (APOE) alleles are associated with longevity in genome-wide scans, with ε4 correlated with shorter life, and ε2 with longer life, than ε3. We hypothesized that rare APOE variants with large individual effects might also contribute to long-term good health. The APOE exons and promoter were resequenced ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.09.010

    authors： Tindale LC,Leach S,Ushey K,Daley D,Brooks-Wilson AR

    更新日期：2014-03-01 00:00:00

  • Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.

    abstract：:Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.07.016

    authors： Mengel-From J,Christensen K,McGue M,Christiansen L

    更新日期：2011-03-01 00:00:00

  • Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

    abstract：:Alzheimer's disease is characterized by amyloid plaques, neurofibrillary tangles, glial activation, and neurodegeneration. In mouse models, inflammatory activation of microglia accelerates tau pathology. The chemokine fractalkine serves as an endogenous neuronal modulator to quell microglial activation. Experiments wi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.12.011

    authors： Nash KR,Lee DC,Hunt JB Jr,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D

    更新日期：2013-06-01 00:00:00

  • The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.

    abstract：:There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease. We measured the concentrations of h...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(01)00327-x

    authors： Selley ML,Close DR,Stern SE

    更新日期：2002-05-01 00:00:00

  • Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease.

    abstract：:In this study we employed an ELISA assay to measure alpha-synuclein protein in lymphomonocytes from 78 PD patients and 78 controls. We correlated protein levels with demographic and clinical characteristics and with the chymotryptic and tryptic activities of the 20S proteasome. Alpha-synuclein levels were not signific...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.06.010

    authors： Brighina L,Prigione A,Begni B,Galbussera A,Andreoni S,Piolti R,Ferrarese C

    更新日期：2010-05-01 00:00:00

  • A noradrenergic theory of cognitive reserve: implications for Alzheimer's disease.

    abstract：:The gap between symptoms and pathology in Alzheimer's disease has been explained by the hypothetical construct of "cognitive reserve"--a set of variables including education, intelligence, and mental stimulation which putatively allow the brain to adapt to-and hence mask--underlying pathologies by maintaining cognitiv...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2012.05.019

    authors： Robertson IH

    更新日期：2013-01-01 00:00:00

  • Regionally specific loss of neurons in the aging human hippocampus.

    abstract：:New highly-accurate stereological methods for estimating the total numbers of neurons in brain structures have been used to test for age-related neuron loss in the human hippocampal formation. Across the age range of 13 to 85 years, there was a substantial loss of neurons in the subiculum (52%) and in the hilus of the...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(93)90113-p

    authors： West MJ

    更新日期：1993-07-01 00:00:00

  • Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.

    abstract：:The present study investigated if a causal relation exists between serum concentrations of precursors and metabolites of cholesterol and cognitive performance in a healthy aging population. Cognitive function addressing four domains of 144 individuals (30-80 years) was tested at baseline and after 6 years of follow-up...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00061-1

    authors： Teunissen CE,De Vente J,von Bergmann K,Bosma H,van Boxtel MP,De Bruijn C,Jolles J,Steinbusch HW,Lütjohann D

    更新日期：2003-01-01 00:00:00

  • Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL.

    abstract：:Detailed analyses of neuronal and astrocyte cell numbers in the ganglion cell layer (GCL) of whole-mounted peripheral retinas from 16 Alzheimer's disease (AD) and 11 control eyes (11 and 9 cases, respectively) demonstrate extensive neuronal loss throughout the entire retina in AD as compared to control eyes. The obser...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(96)00009-7

    authors： Blanks JC,Schmidt SY,Torigoe Y,Porrello KV,Hinton DR,Blanks RH

    更新日期：1996-05-01 00:00:00

  • Investigation of C9orf72 repeat expansions in Parkinson's disease.

    abstract：:Large repeat expansions in the C9orf72 gene were recently reported to be a major cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Given some of the clinical and pathologic overlap between these 2 diseases and Parkinson's disease, we sought to evaluate the presence of these expansions in a c...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.025

    authors： Daoud H,Noreau A,Rochefort D,Paquin-Lanthier G,Gauthier MT,Provencher P,Pourcher E,Dupré N,Chouinard S,Jodoin N,Soland V,Fon EA,Dion PA,Rouleau GA

    更新日期：2013-06-01 00:00:00

  • Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

    abstract：:C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansio...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.08.023

    authors： Kun-Rodrigues C,Ross OA,Orme T,Shepherd C,Parkkinen L,Darwent L,Hernandez D,Ansorge O,Clark LN,Honig LS,Marder K,Lemstra A,Scheltens P,van der Flier W,Louwersheimer E,Holstege H,Rogaeva E,St George-Hyslop P,Londos E,

    更新日期：2017-01-01 00:00:00

  • Motor function in young and aged hemiplegic rats: effects of a Ginkgo biloba extract.

    abstract：:We have previously shown beneficial effects of a Ginkgo biloba extract (EGb761-IPSEN) in accelerating functional recovery from hemiplegia induced by unilateral motor cortex ablation. Here, we report the behavioral and histological effects of various dose regimes of EGb761. In young rats (3 months), 10 mg/kg/day for 7 ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00007-9

    authors： Brailowsky S,Montiel T

    更新日期：1997-03-01 00:00:00

  • Genetic analysis of amyotrophic lateral sclerosis in the Slovenian population.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a complex fatal neurodegenerative disease characterized by progressive degeneration and loss of upper motor neurons in the cerebral cortex and lower motor neurons in brainstem and spinal cord. We established the frequencies of mutations in 4 major ALS-associated genes, SOD1, TARD...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.11.011

    authors： Vrabec K,Koritnik B,Leonardis L,Dolenc-Grošelj L,Zidar J,Smith B,Vance C,Shaw C,Rogelj B,Glavač D,Ravnik-Glavač M

    更新日期：2015-03-01 00:00:00

  • Clinical relevance of specific T-cell activation in the blood and cerebrospinal fluid of patients with mild Alzheimer's disease.

    abstract：:In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The aim of this study was to identify a particular immune profile in the peripheral blood (PB) and cerebrospinal fluid (CSF) in patients with mild Alzheimer's disease (mAD) and mild cognitive impairment (MCI) and its potential...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.08.008

    authors： Lueg G,Gross CC,Lohmann H,Johnen A,Kemmling A,Deppe M,Groger J,Minnerup J,Wiendl H,Meuth SG,Duning T

    更新日期：2015-01-01 00:00:00

  • Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging.

    abstract：:An individual's genetic makeup plays an important role in determining susceptibility to cognitive aging. Identifying the specific genes that contribute to cognitive aging may aid in early diagnosis of at-risk patients, as well as identify novel therapeutics targets to treat or prevent development of symptoms. Challeng...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.06.008

    authors： Neuner SM,Garfinkel BP,Wilmott LA,Ignatowska-Jankowska BM,Citri A,Orly J,Lu L,Overall RW,Mulligan MK,Kempermann G,Williams RW,O'Connell KM,Kaczorowski CC

    更新日期：2016-10-01 00:00:00

  • Is procedural memory relatively spared from age effects?

    abstract：:Numerous types of age-related deficits in the nervous system have been well documented. While a distinction between general types of memories that are susceptible to compromise with advanced age has been fairly well agreed upon, it is often difficult to determine exactly which specific processes are detrimentally infl...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(02)00194-x

    authors： Churchill JD,Stanis JJ,Press C,Kushelev M,Greenough WT

    更新日期：2003-10-01 00:00:00

  • VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from southwest China.

    abstract：:The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, t...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.003

    authors： Chen Y,Chen K,Song W,Chen X,Cao B,Huang R,Zhao B,Guo X,Burgunder J,Li J,Shang HF

    更新日期：2013-06-01 00:00:00

  • Aging is associated with changes in the neural circuits underlying empathy.

    abstract：:Although the neurodevelopment of empathy from childhood to adolescence has been documented, no study has yet examined it across a life span aging perspective. Sixty-five healthy participants from 3 age groups (young, middle-aged, old) underwent functional magnetic resonance imaging while presented with visual stimuli ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.10.080

    authors： Chen YC,Chen CC,Decety J,Cheng Y

    更新日期：2014-04-01 00:00:00

  • Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects.

    abstract：:Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). F...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.11.020

    authors： Samuraki M,Matsunari I,Chen WP,Shima K,Yanase D,Takeda N,Matsuda H,Yamada M

    更新日期：2012-10-01 00:00:00

  • Identification of rare genetic variants in Italian patients with dementia by targeted gene sequencing.

    abstract：:Genetics is intricately involved in the etiology of neurodegenerative dementias. The incidence of monogenic dementia among all neurodegenerative forms is unknown due to the lack of systematic studies and of patient/clinician access to extensive diagnostic procedures. In this study, we conducted targeted sequencing in ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.02.006

    authors： Bartoletti-Stella A,Baiardi S,Stanzani-Maserati M,Piras S,Caffarra P,Raggi A,Pantieri R,Baldassari S,Caporali L,Abu-Rumeileh S,Linarello S,Liguori R,Parchi P,Capellari S

    更新日期：2018-06-01 00:00:00

  • KIBRA gene variants are associated with episodic memory in healthy elderly.

    abstract：:The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an i...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.02.001

    authors： Schaper K,Kolsch H,Popp J,Wagner M,Jessen F

    更新日期：2008-07-01 00:00:00

  • Cross-talk between Aβ and endothelial SSAO/VAP-1 accelerates vascular damage and Aβ aggregation related to CAA-AD.

    abstract：:An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.09.030

    authors： Solé M,Miñano-Molina AJ,Unzeta M

    更新日期：2015-02-01 00:00:00

  • Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation.

    abstract：:Aged rats exhibit an impaired ability to sustain long-term potentiation in dentate gyrus which correlates with a decrease in arachidonic acid concentration. Here we confirm the previous finding that dietary supplementation with arachidonic acid and its precursor, gamma-linolenic acid, reversed the impairment in LTP in...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(99)00027-5

    authors： McGahon BM,Murray CA,Horrobin DF,Lynch

    更新日期：1999-11-01 00:00:00

  • An analog derived from phenylpropanoids ameliorates Alzheimer's disease-like pathology and protects mitochondrial function.

    abstract：:The abnormal proliferation and neurogenesis of neural progenitor cells (NPCs) is usually associated with the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). Mitochondrial stress is one of the most prominent features of AD and is thought to be involved in the impairment of the neurogene...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.05.002

    authors： Huang S,Cao X,Zhou Y,Shi F,Xin S,He S,An Y,Gao L,Yang Y,Yu B,Pei G

    更新日期：2019-08-01 00:00:00

  • Distinctive age-related temporal cortical thinning in asymptomatic granulin gene mutation carriers.

    abstract：:Studies in asymptomatic granulin gene (GRN) mutation carriers are essential to improve our understanding of the pattern and timing of early morphologic brain changes in frontotemporal lobar degeneration. The main objectives of this study were to assess the effect of age in cortical thickness changes (CTh) in preclinic...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.11.005

    authors： Moreno F,Sala-Llonch R,Barandiaran M,Sánchez-Valle R,Estanga A,Bartrés-Faz D,Sistiaga A,Alzualde A,Fernández E,Martí Massó JF,López de Munain A,Indakoetxea B

    更新日期：2013-05-01 00:00:00

  • Aging elevates metabolic gene expression in brain cholinergic neurons.

    abstract：:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F3...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.04.024

    authors： Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney M

    更新日期：2008-12-01 00:00:00

  • Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains.

    abstract：:Nicastrin and presenilin 1 are integral components of the high molecular weight gamma-secretase complexes that regulate proteolytic processing of various type I membrane proteins including amyloid precursor protein and Notch. At present, there is little information regarding the cellular distribution of nicastrin in t...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2006.12.005

    authors： Kodam A,Vetrivel KS,Thinakaran G,Kar S

    更新日期：2008-05-01 00:00:00

  • JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1.

    abstract：:The activity of beta-secretase (BACE1), the endo-protease essential for the production of amyloid beta (Abeta) peptides, is increased in brain of late-onset sporadic Alzheimer's disease (AD), and oxidative stress is the potential cause of this event. Oxidative stress up-regulates the expression and the activity of BAC...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2007.12.015

    authors： Tamagno E,Guglielmotto M,Giliberto L,Vitali A,Borghi R,Autelli R,Danni O,Tabaton M

    更新日期：2009-10-01 00:00:00