Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

abstract：:Abnormal interaction of beta-amyloid 42 (Abeta42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Abeta degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinases. We investig...

journal_title：Neurobiology of aging

authors： Strozyk D,Launer LJ,Adlard PA,Cherny RA,Tsatsanis A,Volitakis I,Blennow K,Petrovitch H,White LR,Bush AI

更新日期：2009-07-01 00:00:00

abstract：:Aging produces a loss in a number of behavioral and cognitive functions, including sleep. Hypocaloric diet is one of the few methods that have been shown to retard the effects due to age. However, the effects of such a diet on sleep have never been investigated. In the present study, 21 months old male F344 rats fed a...

journal_title：Neurobiology of aging

authors： Salin-Pascual RJ,Upadhyay U,Shiromani PJ

更新日期：2002-09-01 00:00:00

abstract：:Nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) in the cholinergic basal forebrain (BF) during sleep deprivation (SD) is implicated in adenosine (AD) release and induction of recovery sleep. Aging is associated with impairments in sleep homeostasis, such as decrease in non-rapid eye movement sleep...

journal_title：Neurobiology of aging

authors： Rytkönen KM,Wigren HK,Kostin A,Porkka-Heiskanen T,Kalinchuk AV

更新日期：2010-11-01 00:00:00

abstract：:Alzheimer's disease of early onset versus that of late onset represent different syndromes, with distinct neuropathologies. Patients with early onset disease exhibit a more severe and more widespread loss of neurons from cortical and sub-cortical regions and the neurochemical changes involve not only the cholinergic s...

journal_title：Neurobiology of aging

authors： Iversen LL

更新日期：1987-11-01 00:00:00

abstract：:We used high-resolution MRI to investigate gray and white matter aging in the major lobes of the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe (temporal pole, superior temporal gyrus, infero-temporal region, parahippocampal gyrus, amygdala, hippocampus). Subjects included...

journal_title：Neurobiology of aging

authors： Allen JS,Bruss J,Brown CK,Damasio H

更新日期：2005-10-01 00:00:00

abstract：:Previous studies found that polymorphisms rs2736990 and rs356220 in the alpha-synuclein (SNCA) gene increase the risk for Parkinson's disease (PD) in a Caucasian population. In consideration of the overlapping of clinical manifestations and pathologic characteristics among PD, amyotrophic lateral sclerosis (ALS), and ...

journal_title：Neurobiology of aging

authors： Guo XY,Chen YP,Song W,Zhao B,Cao B,Wei QQ,Ou RW,Yang Y,Yuan LX,Shang HF

更新日期：2014-12-01 00:00:00

abstract：:The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzh...

journal_title：Neurobiology of aging

authors： Viaña JNM,Vickers JC,Cook MJ,Gilbert F

更新日期：2017-08-01 00:00:00

abstract：:Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD). However, cohorts and methods used to determine such rates are heterogeneous, leading to differences in reported annualised rates. We performed a meta-analysis of hippocampal atrophy rates in AD patients and matched controls ...

journal_title：Neurobiology of aging

authors： Barnes J,Bartlett JW,van de Pol LA,Loy CT,Scahill RI,Frost C,Thompson P,Fox NC

更新日期：2009-11-01 00:00:00

abstract：:Apolipoprotein E (APOE) ε4 is a major risk factor for Alzheimer's disease (AD) and dementia, but not all ε4 carriers develop dementia. We sought to identify factors that may play a role in modifying the risk of dementia due to ε4. A cognitively intact cohort (n = 932, age ≥ 75) was followed for 9 years to detect incid...

journal_title：Neurobiology of aging

authors： Ferrari C,Xu WL,Wang HX,Winblad B,Sorbi S,Qiu C,Fratiglioni L

更新日期：2013-01-01 00:00:00

abstract：:Significant advances in the technology for the isolation of peptides and small proteins have permitted their identification as biologic markers and enhanced the study of the posttranslational life of proteins. The protocol described here examined large numbers of tissue-derived peptides and small proteins, extracted i...

journal_title：Neurobiology of aging

authors： Slemmon JR,Flood DG

更新日期：1992-11-01 00:00:00

abstract：:Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases. Besides their social implications, the different forms of dementia, including Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies or frontotemporal dementia, sh...

journal_title：Neurobiology of aging

authors： Gámez-Valero A,Beyer K,Borràs FE

更新日期：2019-02-01 00:00:00

abstract：:In this study we employed an ELISA assay to measure alpha-synuclein protein in lymphomonocytes from 78 PD patients and 78 controls. We correlated protein levels with demographic and clinical characteristics and with the chymotryptic and tryptic activities of the 20S proteasome. Alpha-synuclein levels were not signific...

journal_title：Neurobiology of aging

authors： Brighina L,Prigione A,Begni B,Galbussera A,Andreoni S,Piolti R,Ferrarese C

更新日期：2010-05-01 00:00:00

abstract：:We examined whether cognitive reserve (CR) impacts level of, or rate of change in, biomarkers of Alzheimer's disease (AD) and small-vessel cerebrovascular disease in >250 individuals who were cognitively normal and middle-aged and older at the baseline. The four primary biomarker categories commonly examined in studie...

journal_title：Neurobiology of aging

authors： Pettigrew C,Soldan A,Zhu Y,Cai Q,Wang MC,Moghekar A,Miller MI,Singh B,Martinez O,Fletcher E,DeCarli C,Albert M

更新日期：2020-04-01 00:00:00

abstract：:Synaptic density in the medial and lateral septal nuclei was examined in 3 and 24-28 months of age Fischer 344 rats. The lateral nucleus had a higher synaptic density than the medial region in both age groups. There were no statistically significant differences in synapse density in either region as a function of age,...

journal_title：Neurobiology of aging

authors： Scheff SW,Scott SA,DeKosky ST

更新日期：1991-01-01 00:00:00

abstract：:The monoamine metabolites homovanillic acid (HVA), 5-hydroxy-indoleacetic acid (5-HIAA) and 4-hydroxy-3-methoxy-phenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 123 patients with Alzheimer's disease (AD) and 57 healthy controls. Despite CSF sampling under strictly standardized conditions, a w...

journal_title：Neurobiology of aging

authors： Blennow K,Wallin A,Gottfries CG,Lekman A,Karlsson I,Skoog I,Svennerholm L

更新日期：1992-01-01 00:00:00

abstract：:Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease risk variants. We examined pleiotropic genetic effects on cognitive impairment conditioned on genetic variants (SNPs) associated with systemic inflammation as measured...

journal_title：Neurobiology of aging

authors： Lutz MW,Casanova R,Saldana S,Kuchibhatla M,Plassman BL,Hayden KM

更新日期：2019-08-01 00:00:00

abstract：:Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

journal_title：Neurobiology of aging

authors： Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

更新日期：2015-01-01 00:00:00

abstract：:To investigate developmental and vascular risk factors for Alzheimer's disease (AD), we examined 90 incident cases of probable AD in a cohort of 1859 individuals followed prospectively for six years. The presence of the APOE-epsilon4 allele was the strongest risk factor, and with increasing survival age, the effect of...

journal_title：Neurobiology of aging

authors： Borenstein AR,Wu Y,Mortimer JA,Schellenberg GD,McCormick WC,Bowen JD,McCurry S,Larson EB

更新日期：2005-03-01 00:00:00

abstract：:Lipsitz and Goldberger proposed that there is a loss in the complexity of physiological and behavioral systems with aging and disease. Here, we show that this unidirectional view of the change in system complexity is too narrow in its consideration of the actual changes that occur with aging and disease. An increase o...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Newell KM

更新日期：2002-01-01 00:00:00

abstract：:Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been foun...

journal_title：Neurobiology of aging

authors： Siitonen A,Nalls MA,Hernández D,Gibbs JR,Ding J,Ylikotila P,Edsall C,Singleton A,Majamaa K

更新日期：2017-05-01 00:00:00

abstract：:Behavioral profiles of young (3-6 months) and aged (24-27 months) rats were compared in three respects: (1) short-term memory, (2) exploration and (3) locomotor activity. Compared to young rats, aged rats were impaired in the 8-arm radial maze acquisition, but not in the delayed reinforced alternation acquisition. The...

journal_title：Neurobiology of aging

authors： Willig F,Palacios A,Monmaur P,M'Harzi M,Laurent J,Delacour J

更新日期：1987-09-01 00:00:00

abstract：:Decreases in the activity or density of dopamine D2 receptor (D2R) have been associated with age-related changes and neurodegenerative diseases such as Parkinson's disease. There are two isoforms of the D2R, termed the D2 long receptor (D2LR) and D2 short receptor (D2SR). To study the function of these two isoforms an...

journal_title：Neurobiology of aging

authors： Fetsko LA,Xu R,Wang Y

更新日期：2005-04-01 00:00:00

abstract：:Alzheimer's disease (AD) is a genetically complex disorder for which the definite diagnosis is only accomplished postmortem. Mutations in 3 genes (APP, PSEN1, and PSEN2) are known to cause AD, but a large number of familial cases do not harbor mutations in these genes and several unidentified genes that contain diseas...

journal_title：Neurobiology of aging

authors： Guerreiro RJ,Lohmann E,Kinsella E,Brás JM,Luu N,Gurunlian N,Dursun B,Bilgic B,Santana I,Hanagasi H,Gurvit H,Gibbs JR,Oliveira C,Emre M,Singleton A

更新日期：2012-05-01 00:00:00

abstract：:Alzheimer disease (AD) is characterised by a decrease of platelet Amyloid Precursor Protein forms ratio (APPr), which parallels symptoms' severity. Recent studies have suggested that cholesterol might play a role in the pathophysiology of AD by modulating Abeta production. Aim of this study was to evaluate the relatio...

journal_title：Neurobiology of aging

authors： Borroni B,Colciaghi F,Lenzi GL,Caimi L,Cattabeni F,Di Luca M,Padovani A

更新日期：2003-09-01 00:00:00

abstract：:Poor cognitive performance of elderly individuals with low educational attainment is often difficult to interpret in dementia evaluation. Lack of education, as well as dementia, is often associated with poor cognitive test performance. To elucidate the underlying structural change of low cognitive performance in elder...

journal_title：Neurobiology of aging

authors： Chey J,Na DG,Tae WS,Ryoo JW,Hong SB

更新日期：2006-09-01 00:00:00

abstract：:We previously established a single-neuron culture system to analyze the primary effects of neurotrophic factors and reported that NGF promoted neurite extension in young adult (4- to 6-month-old) rat dorsal root ganglion (DRG) neurons by promoting neurite arborization. In this study, we demonstrated that the effects o...

journal_title：Neurobiology of aging

authors： Itoh T,Sobue G,Yasuda T,Kimata K,Mitsuma T,Takahashi A

更新日期：1993-03-01 00:00:00

abstract：:The total number of immunocytochemically identified vasopressin (AVP) cells was determined morphometrically in the paraventricular (PVN) and dorsolateral part of the supraoptic nucleus (dl-SON) of the human hypothalamus in 30 subjects ranging in age from 15 to 97 years, including 10 Alzheimer's disease (AD) patients. ...

journal_title：Neurobiology of aging

authors： Van der Woude PF,Goudsmit E,Wierda M,Purba JS,Hofman MA,Bogte H,Swaab DF

更新日期：1995-01-01 00:00:00

abstract：:Dualistic effects of acetylcholine-esterase inhibitors on neuronal as well as vasoregulative function have been debated. This study investigated for the first time effects of medication on both components. Visually evoked potentials and resultant hemodynamic responses were assessed in Alzheimer patients (n=31) without...

journal_title：Neurobiology of aging

authors： Rosengarten B,Paulsen S,Burr O,Kaps M

更新日期：2009-12-01 00:00:00

abstract：:Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Severa...

journal_title：Neurobiology of aging

authors： Bullido MJ,Martínez-García A,Artiga MJ,Aldudo J,Sastre I,Gil P,Coria F,Muñoz DG,Hachinski V,Frank A,Valdivieso F

更新日期：2007-04-01 00:00:00

abstract：:The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of...

journal_title：Neurobiology of aging

authors： Josephs KA,Whitwell JL,Dickson DW,Boeve BF,Knopman DS,Petersen RC,Parisi JE,Jack CR Jr

更新日期：2008-02-01 00:00:00