Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

abstract：:Our objective was to examine associations between glucose metabolism, as measured by (18)F-fluorodeoxyglucose positron emission tomography (FDG PET), and age and to evaluate the impact of carriage of an apolipoprotein E (APOE) ε4 allele on glucose metabolism and on the associations between glucose metabolism and age. ...

journal_title：Neurobiology of aging

authors： Knopman DS,Jack CR Jr,Wiste HJ,Lundt ES,Weigand SD,Vemuri P,Lowe VJ,Kantarci K,Gunter JL,Senjem ML,Mielke MM,Roberts RO,Boeve BF,Petersen RC

更新日期：2014-09-01 00:00:00

abstract：:An experiment was performed to test the ability of Centrophenoxine to reduce the amount of lipofuscin (age pigment) in the retinal pigment epithelium (RPE) of aged rhesus monkeys. Centrophenoxine is reputed to have this action in neurons of lower mammals. Quantitative electron microscopic analysis was performed on sec...

journal_title：Neurobiology of aging

authors： Andrews LD,Brizzee KR

更新日期：1986-03-01 00:00:00

abstract：:The available published guidelines for the housing of rodents are reviewed, and assessments are made with regard to whether the data on which these guidelines are based appear to be sound. Ambient air temperature, relative humidity, lighting levels and photoperiods, sound levels, cage sizes, and ventilation rates are ...

journal_title：Neurobiology of aging

authors： Clough G

更新日期：1991-11-01 00:00:00

abstract：:The reaction of lysine and arginine residues of proteins with 1,2-dicarbonyl compounds result in the formation of advanced glycation end products (AGEs). Accumulation of AGEs is a characteristic feature of the aging brain and contributes to the development of neurodegenerative diseases such as Alzheimer's disease (AD)...

journal_title：Neurobiology of aging

authors： Kuhla B,Boeck K,Schmidt A,Ogunlade V,Arendt T,Münch G,Lüth HJ

更新日期：2007-01-01 00:00:00

abstract：:We measured midbrain structures of 194 subjects without neurological disorders, using T2-weighted MR imaging. Age was negatively correlated with the maximum anteroposterior distance of the midbrain through the substantia nigra (MD), and the average distance from the substantia nigra to the red nucleus (SNRND), while a...

journal_title：Neurobiology of aging

authors： Sohmiya M,Tanaka M,Aihara Y,Hirai S,Okamoto K

更新日期：2001-07-01 00:00:00

abstract：:Chronic hypertension during aging is a serious threat to the cerebral vasculature. The larger brain arteries can react to hypertension with an abnormal wall thickening, a loss of elasticity and a narrowed lumen. However, little is known about the hypertension-induced alterations of cerebral capillaries. The present st...

journal_title：Neurobiology of aging

authors： Farkas E,De Jong GI,Apró E,Keuker JI,Luiten PG

更新日期：2001-03-01 00:00:00

abstract：:beta A4 peptide (beta AP) accumulates in amyloid plaques of Alzheimer's disease and may contribute to neuronal degeneration. Conflicting observations have been reported regarding the direct in vitro and in vivo neurotoxicity of beta AP. We have assessed in vitro beta AP toxicity in high density primary rat hippocampal...

journal_title：Neurobiology of aging

authors： May PC,Gitter BD,Waters DC,Simmons LK,Becker GW,Small JS,Robison PM

更新日期：1992-09-01 00:00:00

abstract：:Progranulin (GRN) gene mutations have been genetically associated with frontotemporal dementia (FTD) and are present in about 23% of patients with familial FTD. However, the neurobiology of this secreted glycoprotein remains unclear. Here, we report the identification of 3 pedigrees of Southern Italian extraction in w...

journal_title：Neurobiology of aging

authors： Milan G,Napoletano S,Pappatà S,Gentile MT,Colucci-D'Amato L,Della Rocca G,Maciag A,Rossetti CP,Fucci L,Puca A,Grossi D,Postiglione A,Vitale E

更新日期：2017-05-01 00:00:00

abstract：:The loss of presynaptic markers is thought to represent a strong pathologic correlate of cognitive decline in Alzheimer's disease (AD). Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. We assessed total numbers of spinophilin-immunoreactive puncta in the CA1 and CA3 fields of hippo...

journal_title：Neurobiology of aging

authors： Akram A,Christoffel D,Rocher AB,Bouras C,Kövari E,Perl DP,Morrison JH,Herrmann FR,Haroutunian V,Giannakopoulos P,Hof PR

更新日期：2008-09-01 00:00:00

abstract：:Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). F...

journal_title：Neurobiology of aging

authors： Samuraki M,Matsunari I,Chen WP,Shima K,Yanase D,Takeda N,Matsuda H,Yamada M

更新日期：2012-10-01 00:00:00

abstract：:Mutations in the profilin 1 (PFN1) gene, encoding a member of the profilin family of small actin-binding proteins, have been recently reported in patients with familial amyotrophic lateral sclerosis (ALS). In this study we aimed to determine the prevalence of PFN1 mutations by sequencing the coding region of this gene...

journal_title：Neurobiology of aging

authors： Daoud H,Dobrzeniecka S,Camu W,Meininger V,Dupré N,Dion PA,Rouleau GA

更新日期：2013-04-01 00:00:00

abstract：:Recent studies have implicated increased oxidative stress in the pathogenesis of Alzheimer's disease (AD). Increased lipid peroxidation and decreased polyunsaturated fatty acid levels have been described in the brain in AD. Four-hydroxynonenal (HNE), an aldehyde product of lipid peroxidation, has been demonstrated to ...

journal_title：Neurobiology of aging

authors： Markesbery WR,Lovell MA

更新日期：1998-01-01 00:00:00

abstract：:Aging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeost...

journal_title：Neurobiology of aging

authors： Viola AU,Chellappa SL,Archer SN,Pugin F,Götz T,Dijk DJ,Cajochen C

更新日期：2012-05-01 00:00:00

abstract：:Recent results support the hypothesis that microglia and/or macrophages of the brain, by producing oxidants, could play a role in the local inactivation of the Kunitz protease inhibitor (KPI) domain of beta-amyloid precursor protein (APP), thereby facilitating deposition of abnormal amyloid filaments in patients with ...

journal_title：Neurobiology of aging

authors： DeFeudis FV

更新日期：1989-09-01 00:00:00

abstract：:Sex differences in cerebral white matter (WM) aging have been debated extensively over the past 2 decades without unequivocal resolution. We aimed to determine if the effects of age and arterial stiffness on WM microstructure differ between sexes. Artery elasticity via carotid artery compliance (CAC) and WM diffusion ...

journal_title：Neurobiology of aging

authors： Pasha EP,Birdsill AC,Oleson S,Tanaka H,Haley AP

更新日期：2018-06-01 00:00:00

abstract：:The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV-1-associated neurocognitive disorder. As well, these individuals are increasingly experiencing Alzheimer's disease (AD)-like neurocognitive problems and neuropathological features such as increased deposition o...

journal_title：Neurobiology of aging

authors： Chen X,Hui L,Geiger NH,Haughey NJ,Geiger JD

更新日期：2013-10-01 00:00:00

abstract：:The abnormal proliferation and neurogenesis of neural progenitor cells (NPCs) is usually associated with the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). Mitochondrial stress is one of the most prominent features of AD and is thought to be involved in the impairment of the neurogene...

journal_title：Neurobiology of aging

authors： Huang S,Cao X,Zhou Y,Shi F,Xin S,He S,An Y,Gao L,Yang Y,Yu B,Pei G

更新日期：2019-08-01 00:00:00

abstract：:Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand...

journal_title：Neurobiology of aging

authors： Bradburn S,McPhee J,Bagley L,Carroll M,Slevin M,Al-Shanti N,Barnouin Y,Hogrel JY,Pääsuke M,Gapeyeva H,Maier A,Sipilä S,Narici M,Robinson A,Mann D,Payton A,Pendleton N,Butler-Browne G,Murgatroyd C

更新日期：2018-03-01 00:00:00

abstract：:Alzheimer disease (AD) is characterised by a decrease of platelet Amyloid Precursor Protein forms ratio (APPr), which parallels symptoms' severity. Recent studies have suggested that cholesterol might play a role in the pathophysiology of AD by modulating Abeta production. Aim of this study was to evaluate the relatio...

journal_title：Neurobiology of aging

authors： Borroni B,Colciaghi F,Lenzi GL,Caimi L,Cattabeni F,Di Luca M,Padovani A

更新日期：2003-09-01 00:00:00

abstract：:Appreciation of the role that inflammatory mediators play in Alzheimer's disease (AD) pathogenesis continues to be hampered by two related misconceptions. The first is that to be pathogenically significant a neurodegenerative mechanism must be primary. The second is that inflammation merely occurs to clear the detriti...

journal_title：Neurobiology of aging

authors： Rogers J,Webster S,Lue LF,Brachova L,Civin WH,Emmerling M,Shivers B,Walker D,McGeer P

更新日期：1996-09-01 00:00:00

abstract：:The number of Alzheimer's disease sufferers shows an alarming increase throughout the world. Therefore elucidation of the pathogenic mechanisms leading to Alzheimer's disease and the design of effective treatment, preventive or curative, became imperative. In the last few years several groups have found evidence indic...

journal_title：Neurobiology of aging

authors： Nagy Z

更新日期：2000-11-01 00:00:00

abstract：:The midsagittal cross-sectional dimensions of the corpus callosum, the coronal cross-sectional area of the lateral ventricles at the level of the pons, and a three-dimensional estimate of intracranial volume were derived from magnetic resonance brain images obtained from 45 monozygotic and 40 dizygotic male twin pairs...

journal_title：Neurobiology of aging

authors： Pfefferbaum A,Sullivan EV,Swan GE,Carmelli D

更新日期：2000-01-01 00:00:00

abstract：:The Asp620Asn mutation in the vacuolar protein sorting protein 35 (VPS35) gene and the Arg1205His mutation in the eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) gene were identified in autosomal dominant late-onset familial and sporadic Parkinson disease (PD) patients in a Caucasian population. However, t...

journal_title：Neurobiology of aging

authors： Chen Y,Chen K,Song W,Chen X,Cao B,Huang R,Zhao B,Guo X,Burgunder J,Li J,Shang HF

更新日期：2013-06-01 00:00:00

abstract：:Sleep benefits memory across a range of tasks for young adults. However, remarkably little is known of the role of sleep on memory for healthy older adults. We used 2 tasks, 1 assaying motor skill learning and the other assaying nonmotor/declarative learning, to examine off-line changes in performance in young (20-34 ...

journal_title：Neurobiology of aging

authors： Wilson JK,Baran B,Pace-Schott EF,Ivry RB,Spencer RM

更新日期：2012-05-01 00:00:00

abstract：:Using a dosing paradigm and an automated behavioral testing procedure designed to maximize potential drug efficacy, we evaluated the ability of clonidine to improve performance of aged monkeys on a trial-specific memory task. These results indicated that neither acutely administered (0.0025-0.04 mg/kg) or subchronical...

journal_title：Neurobiology of aging

authors： Bartus RT,Dean RL

更新日期：1988-07-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Whole-exome sequencing recently identified a homozygous truncating mutation in Synaptojanin 1 (SYNJ1, PARK20), p.Arg258Gln, in 2 independent families with autosomal recessive young-onset parkinsonism with seizures and cognitive decline. This mutation's role in typical Parkinson's disease (PD) is unclear. We sequenced ...

journal_title：Neurobiology of aging

authors： Chen KH,Wu RM,Lin HI,Tai CH,Lin CH

更新日期：2015-10-01 00:00:00

abstract：:This proteomic study investigates the widely observed clinical phenomenon, that after comparable brain injuries, geriatric patients fare worse and recover less cognitive and neurologic function than younger victims. Utilizing a rat traumatic brain injury model, sham surgery or a neocortical contusion was induced in 3 ...

journal_title：Neurobiology of aging

authors： Mehan ND,Strauss KI

更新日期：2012-09-01 00:00:00

abstract：:CR1 is a novel Alzheimer's disease (AD) gene identified by genome-wide association studies (GWAS). Recently, we showed that AD risk could be explained by an 18-kilobase insertion responsible for the complement component (3b/4b) receptor 1 (CR1)-S isoform. We investigated the relevance of the CR1 isoforms to AD in a Ca...

journal_title：Neurobiology of aging

authors： Hazrati LN,Van Cauwenberghe C,Brooks PL,Brouwers N,Ghani M,Sato C,Cruts M,Sleegers K,St George-Hyslop P,Van Broeckhoven C,Rogaeva E

更新日期：2012-12-01 00:00:00

abstract：:To determine whether polymorphisms in the microtubule-associated protein tau (MAPT) and/or glycogen synthase kinase-3β (GSK3β) genes underpin susceptibility to Parkinson's disease (PD), we conducted a case-control association study in a Greek cohort of 196 PD cases and 163 healthy controls. In our study, the MAPT H1 h...

journal_title：Neurobiology of aging

authors： Kalinderi K,Fidani L,Katsarou Z,Clarimón J,Bostantjopoulou S,Kotsis A

更新日期：2011-03-01 00:00:00