Abstract：
:The basal forebrain (BF) cholinergic system is selectively vulnerable in human brain diseases, while the cholinergic groups in the upper pons of the brainstem (BS) resist neurodegeneration. Cholinergic neurons (200 per region per animal) were laser-microdissected from five young (8 months) and five aged (24 months) F344 rats from the BF and the BS pontine lateral dorsal tegmental/pedunculopontine nuclei (LDTN/PPN) and their expression profiles were obtained. The bioinformatics program SigPathway was used to identify gene groups and pathways that were selectively affected by aging. In the BF cholinergic system, aging most significantly altered genes involved with a variety of metabolic functions. In contrast, BS cholinergic neuronal age effects included gene groupings related to neuronal plasticity and a broad range of normal cellular functions. Transcription factor GA-binding protein alpha (GABPalpha), which controls expression of nuclear genes encoding mitochondrial proteins, was more strongly upregulated in the BF cholinergic neurons (+107%) than in the BS cholinergic population (+40%). The results suggest that aging elicits elevates metabolic activity in cholinergic populations and that this occurs to a much greater degree in the BF group than in the BS group.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Baskerville KA,Kent C,Personett D,Lai WR,Park PJ,Coleman P,McKinney Mdoi
10.1016/j.neurobiolaging.2007.04.024subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1874-93issue
12eissn
0197-4580issn
1558-1497pii
S0197-4580(07)00199-6journal_volume
29pub_type
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