Abstract：
:It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Lövdén M,Schaefer S,Noack H,Bodammer NC,Kühn S,Heinze HJ,Düzel E,Bäckman L,Lindenberger Udoi
10.1016/j.neurobiolaging.2011.02.013subject
Has Abstractpub_date
2012-03-01 00:00:00pages
620.e9-620.e22issue
3eissn
0197-4580issn
1558-1497pii
S0197-4580(11)00042-Xjournal_volume
33pub_type
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