Abstract:
:Age related alterations in mnemonic ability and in the functional status of muscarinic receptors were evaluated and compared to biochemical measures of pre and post-synaptic cholinergic functioning. Retention of a single trial passive avoidance task was considerably disturbed as a function of aging. The functional status of muscarinic receptors, as measured by the ability of microiontophoretically applied acetylcholine to stimulate the firing of hippocampal pyramidal cells, was similarly disturbed in aged rats. A small, but significant decrease in muscarinic receptors was detected in the dorsal hippocampi of these same aged rats, while choline acetyltransferase activity did not change. When considered with prior psychopharmacological studies, these data suggest that specific muscarinic receptor impairments may play a critical role in the memory disturbances associated with old age.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Lippa AS,Pelham RW,Beer B,Critchett DJ,Dean RL,Bartus RTdoi
10.1016/0197-4580(80)90019-6subject
Has Abstractpub_date
1980-07-01 00:00:00pages
13-9issue
1eissn
0197-4580issn
1558-1497pii
0197-4580(80)90019-6journal_volume
1pub_type
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