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Associations of carotid arterial compliance and white matter diffusion metrics during midlife: modulation by sex.

Abstract：

:Sex differences in cerebral white matter (WM) aging have been debated extensively over the past 2 decades without unequivocal resolution. We aimed to determine if the effects of age and arterial stiffness on WM microstructure differ between sexes. Artery elasticity via carotid artery compliance (CAC) and WM diffusion metrics via diffusion tensor image-derived fractional anisotropy (FA) and mean diffusivity (MD) were measured in 155 (87 females) middle-aged (40-62 years) adults. Males demonstrated poorer water diffusion metrics in WM than women in the corpus callosum body, cingulum, and cingulum (hippocampal). Age and CAC had greater effects on WM water diffusion in males than females in midlife independent of education and cardiovascular risk factors. Sex-moderated age (cingulum FA, cingulum [hippocampal] MD, and uncinate MD, all p < 0.05) and CAC (cingulum FA, p < 0.05) related reductions in regional WM diffusion metrics. CAC mediated age-related associations in regional WM diffusion metrics (cingulum FA, cingulum MD, superior corona radiata MD, and uncinate MD, all p < 0.05) in males but not in females. Age and CAC were associated with WM diffusion metrics independent of cardiovascular risk factors. These associations appear to be stronger in males than in females.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Pasha EP,Birdsill AC,Oleson S,Tanaka H,Haley AP

doi

10.1016/j.neurobiolaging.2018.02.012

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

59-67

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(18)30055-1

journal_volume

66

pub_type

杂志文章

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