Herpes virus in Alzheimer's disease: relation to progression of the disease.

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up. The individuals (n = 20, age from 49-98 years) included in this study were carefully examined for absence of neurologica...

journal_title：Neurobiology of aging

authors： Ohm TG,Busch C,Bohl J

更新日期：1997-07-01 00:00:00

abstract：:Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent generation of amyloid beta (Aβ) are central to the pathogenesis of Alzheime...

journal_title：Neurobiology of aging

authors： Cox CJ,Choudhry F,Peacey E,Perkinton MS,Richardson JC,Howlett DR,Lichtenthaler SF,Francis PT,Williams RJ

更新日期：2015-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by loss of motor neurons. We have recently identified SOD1 and FUS mutations as the most common causes in a consecutive series of 111 familial ALS pedigrees in Japan. To reveal possible genetic causes for the remaining 51 pat...

journal_title：Neurobiology of aging

authors： Nishiyama A,Niihori T,Warita H,Izumi R,Akiyama T,Kato M,Suzuki N,Aoki Y,Aoki M

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether cognitive function in the spectrum of normal aging to Alzheimer's disease is better reflected in MRI or EEG measures, or a combination of both. METHODS:Cognitive functions were tested in 33 elderly subjects: 10 with probable Alzheimer's disease, 11 with mild cognitive impairment and 12...

journal_title：Neurobiology of aging

authors： van der Hiele K,Vein AA,van der Welle A,van der Grond J,Westendorp RG,Bollen EL,van Buchem MA,van Dijk JG,Middelkoop HA

更新日期：2007-09-01 00:00:00

abstract：:Although senile plaques represent a consistent neuropathological feature in Alzheimer's brains, it is not known what role plaques play in the etiology of the disease. Both growth-promoting and growth-inhibiting influences have been postulated. One of the major components in plaques, beta-amyloid, has been shown to aff...

journal_title：Neurobiology of aging

authors： Carpenter MK,Crutcher KA,Kater SB

更新日期：1993-05-01 00:00:00

abstract：:Age-related cognitive decline is likely promoted by accumulated brain injury due to chronic conditions of aging, including neurodegenerative and vascular disease. Because common neuronal mechanisms may mediate the adaptation to diverse cerebral insults, we hypothesized that susceptibility for age-related cognitive dec...

journal_title：Neurobiology of aging

authors： De Jager PL,Shulman JM,Chibnik LB,Keenan BT,Raj T,Wilson RS,Yu L,Leurgans SE,Tran D,Aubin C,Anderson CD,Biffi A,Corneveaux JJ,Huentelman MJ,Alzheimer's Disease Neuroimaging Initiative.,Rosand J,Daly MJ,Myers AJ,Reiman

更新日期：2012-05-01 00:00:00

abstract：:Aged, cognitively-impaired rats (and humans) show hypothalamic-pituitary-adrenal (HPA) hyperactivity that correlates with hippocampal damage. The resultant increase in plasma glucocorticoid exposure is thought to contribute to impaired hippocampal function and to potentiate hippocampal neuron death. In young, adult ra...

journal_title：Neurobiology of aging

authors： Rowe W,Steverman A,Walker M,Sharma S,Barden N,Seckl JR,Meaney MJ

更新日期：1997-09-01 00:00:00

abstract：:Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the regulator of G-protein signaling-10 (RGS10) locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, ...

journal_title：Neurobiology of aging

authors： Kannarkat GT,Lee JK,Ramsey CP,Chung J,Chang J,Porter I,Oliver D,Shepherd K,Tansey MG

更新日期：2015-05-01 00:00:00

abstract：:Patients with posterior cortical atrophy (PCA-AD) show more severe visuospatial and perceptual deficits than those with typical AD (tAD). The aim of this study was to investigate whether functional alterations measured by electroencephalography can help understand the mechanisms that explain this clinical heterogeneit...

journal_title：Neurobiology of aging

authors： Briels CT,Eertink JJ,Stam CJ,van der Flier WM,Scheltens P,Gouw AA

更新日期：2020-12-01 00:00:00

abstract：:In Alzheimer's disease (AD) inflammatory processes occur in pathologically vulnerable brain regions. The objective of this study is to compare both the release and the presence of microvessel-associated cytokines in vessels isolated from the brains of AD patients to microvessels from control brains. Microvessels are i...

journal_title：Neurobiology of aging

authors： Grammas P,Ovase R

更新日期：2001-11-01 00:00:00

abstract：:Cross-sectional studies have found declines in most measures of oculomotor function in older subjects compared to young controls, but no prior study has followed the same subjects over time. We measured saccade peak velocity, saccade delay time, smooth pursuit, optokinetic nystagmus (OKN), visual-vestibular-ocular-ref...

journal_title：Neurobiology of aging

authors： Kerber KA,Ishiyama GP,Baloh RW

更新日期：2006-09-01 00:00:00

abstract：:The ability to maintain cognitive function during aging is a complex process subject to genetic and environmental influences. Alzheimer's disease (AD) is the most common disorder causing cognitive decline among the elderly. Among those with AD, there is broad variation in the relationship between AD neuropathology and...

journal_title：Neurobiology of aging

authors： Wilmot B,McWeeney SK,Nixon RR,Montine TJ,Laut J,Harrington CA,Kaye JA,Kramer PL

更新日期：2008-04-01 00:00:00

abstract：:N-Methyl-D-Aspartate (NMDA) receptors are believed to play a critical role in excitotoxic cell death in the CNS. The distribution of NMDA-preferring binding sites is compared here with the patterns of selective neuronal death observed in Alzheimer's disease and following transient ischemia. The distribution of NMDA re...

journal_title：Neurobiology of aging

authors： Lee KS

更新日期：1989-09-01 00:00:00

abstract：:An extensive literature reports changes in quantitative electroencephalogram (QEEG) with aging and a relationship between magnitude of changes and degree of clinical deterioration in progressive dementia. Longitudinal studies have demonstrated QEEG differences between mild cognitively impaired (MCI) elderly who go on ...

journal_title：Neurobiology of aging

authors： Prichep LS,John ER,Ferris SH,Rausch L,Fang Z,Cancro R,Torossian C,Reisberg B

更新日期：2006-03-01 00:00:00

abstract：:An association between semicarbazide-sensitive amine oxidase (SSAO) and cerebral amyloid angiopathy (CAA) related to Alzheimer's disease (AD) has been largely postulated. Increased SSAO activity and expression have been detected in cerebrovascular tissue and plasma of AD patients, colocalizing with cerebrovascular amy...

journal_title：Neurobiology of aging

authors： Solé M,Miñano-Molina AJ,Unzeta M

更新日期：2015-02-01 00:00:00

abstract：:Amyloid beta (Aβ) peptide, the main component of senile plaques in patients with Alzheimer's disease (AD), is derived from proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretases. Alpha-cleavage of APP by α-secretase has a potential to preclude the generation of Aβ because it occurs within the A...

journal_title：Neurobiology of aging

authors： Ohno M,Hiraoka Y,Lichtenthaler SF,Nishi K,Saijo S,Matsuoka T,Tomimoto H,Araki W,Takahashi R,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:The Parkinson's disease (PD)-related inclusion body pathology comprises Lewy bodies (LBs) as well as Lewy neurites (LNs). The distribution and severity of this pathology were investigated in the thalamus of 12 autopsy cases with clinically diagnosed and neuropathologically confirmed PD. The LBs and LNs were visualized...

journal_title：Neurobiology of aging

authors： Rüb U,Del Tredici K,Schultz C,Ghebremedhin E,de Vos RA,Jansen Steur E,Braak H

更新日期：2002-03-01 00:00:00

abstract：:Amyloid precursor protein (APP), a key molecule of Alzheimer disease, is metabolized in 2 antagonist pathways generating the soluble APP alpha (sAPPα) having neuroprotective properties and the beta amyloid (Aβ) peptide at the origin of neurotoxic oligomers, particularly Aβ1-42. Whether extracellular Aβ1-42 oligomers m...

journal_title：Neurobiology of aging

authors： Rose C,Dorard E,Audrain M,Gorisse-Hussonnois L,Cartier N,Braudeau J,Allinquant B

更新日期：2018-01-01 00:00:00

abstract：:Visual short-term memory (vSTM) is a cognitive resource that declines with age. This study investigated whether electroencephalography (EEG) correlates of vSTM vary with cognitive development over individuals' lifespan. We measured vSTM performance and EEG in a lateralized whole-report task in a healthy birth cohort, ...

journal_title：Neurobiology of aging

authors： Wiegand I,Lauritzen MJ,Osler M,Mortensen EL,Rostrup E,Rask L,Richard N,Horwitz A,Benedek K,Vangkilde S,Petersen A

更新日期：2018-02-01 00:00:00

abstract：:The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to...

journal_title：Neurobiology of aging

authors： Larsson M,Hedner M,Papenberg G,Seubert J,Bäckman L,Laukka EJ

更新日期：2016-02-01 00:00:00

abstract：:Type 2 diabetes mellitus is a risk factor of Alzheimer's disease (AD), most likely linked to an impairment of insulin signaling in the brain. Liraglutide, a novel long-lasting glucagon-like peptide 1 (GLP-1) analog, facilitates insulin signaling and shows neuroprotective properties. In the present study, we analyzed t...

journal_title：Neurobiology of aging

authors： Han WN,Hölscher C,Yuan L,Yang W,Wang XH,Wu MN,Qi JS

更新日期：2013-02-01 00:00:00

abstract：:The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease have not yet been clarified, and it is not known whether there is a critical period. Estrogen induced significant protection against 6-hydroxydopamine-induced dopaminergic degeneration when administered immediately or 6 weeks, but not 20...

journal_title：Neurobiology of aging

authors： Rodriguez-Perez AI,Borrajo A,Valenzuela R,Lanciego JL,Labandeira-Garcia JL

更新日期：2015-02-01 00:00:00

abstract：:Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). Subsequent studies identified similar indels in controls and suggested that these indels may confer susceptibility to ALS. We aimed to el...

journal_title：Neurobiology of aging

authors： Rutherford NJ,Finch NA,DeJesus-Hernandez M,Crook RJ,Lomen-Hoerth C,Wszolek ZK,Uitti RJ,Graff-Radford NR,Rademakers R

更新日期：2012-02-01 00:00:00

abstract：:The objective of this study was to determine whether physiological fluctuations in white matter (PFWM) on resting-state functional magnetic resonance images could be used as an index of neurodegeneration and Alzheimer's disease (AD). Using resting-state functional magnetic resonance image data from participants in the...

journal_title：Neurobiology of aging

authors： Makedonov I,Chen JJ,Masellis M,MacIntosh BJ,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2016-01-01 00:00:00

abstract：:The growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg SC) was studied in young and elderly normal subjects as well as in patients with dementia of the Alzheimer type (DAT) and controls matched for age, gender and Quetelet index. The GH response was significantly decrease...

journal_title：Neurobiology of aging

authors： Lal S,Nair NP,Thavundayil JX,Tawar V,Tesfaye Y,Dastoor D,Gauthier S,Guyda H

更新日期：1989-05-01 00:00:00

abstract：:To identify genes associated with frontotemporal dementia (FTD) in South-East Asia, targeted exome sequencing and C9orf72 genotyping was performed in 198 subjects (52 patients with FTD and 146 healthy controls) who were screened for mutations in 12 FTD-associated genes. We detected a homozygous TREM2 R47C mutation in ...

journal_title：Neurobiology of aging

authors： Ng ASL,Tan YJ,Yi Z,Tandiono M,Chew E,Dominguez J,Macas M,Ng E,Hameed S,Ting S,Tan EK,Foo JN,Kandiah N

更新日期：2018-08-01 00:00:00

abstract：:This commentary addresses issues raised in common by the various authors of papers in this section: the role of different chemical systems in memory, new approaches for assessing the effects of drugs, and issues for the future in evaluating animal models of human disorders of memory. ...

journal_title：Neurobiology of aging

authors： Whitehouse PJ

更新日期：1988-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder involving the progressive degeneration of motor neurons in the brain and spinal cord. Mitochondrial dysfunction plays a key role in ALS disease progression and has been observed in several ALS cellular and animal models. Here, we show that fibro...

journal_title：Neurobiology of aging

authors： Allen SP,Rajan S,Duffy L,Mortiboys H,Higginbottom A,Grierson AJ,Shaw PJ

更新日期：2014-06-01 00:00:00

abstract：:Astrocytes and microglia from cerebral cortex of 3-, 6-, 12-, and 24-month-old F344 male rat donors showed progressively greater proliferation during primary culture. Microglia from aging donor brains exhibited an amoeboid-like morphology and express antigens characteristic of an activated state (e.g., major histocomp...

journal_title：Neurobiology of aging

authors： Rozovsky I,Finch CE,Morgan TE

更新日期：1998-01-01 00:00:00