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Olfactory memory in the old and very old: relations to episodic and semantic memory and APOE genotype.

Abstract：

:The neuroanatomical organization that underlies olfactory memory is different from that of other memory types. The present work examines olfactory memory in an elderly population-based sample (Swedish National Study on Aging and Care in Kungsholmen) aged 60-100 years (n = 2280). We used structural equation modeling to investigate whether olfactory memory in old age is best conceptualized as a distinct category, differentiated from episodic and semantic memory. Further, potential olfactory dedifferentiation and genetic associations (APOE) to olfactory function in late senescence were investigated. Results are in support of a 3-factor solution where olfactory memory, as indexed by episodic odor recognition and odor identification, is modeled separately from episodic and semantic memory for visual and verbal information. Increasing age was associated with poorer olfactory memory performance, and observed age-related deficits were further exacerbated for carriers of the APOE ε4 allele; these effects tended to be larger for olfactory memory compared to episodic and semantic memory pertaining to other sensory systems (vision, auditory). Finally, stronger correlations between olfactory and episodic memory, indicating dedifferentiation, were observed in the older age groups.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Larsson M,Hedner M,Papenberg G,Seubert J,Bäckman L,Laukka EJ

doi

10.1016/j.neurobiolaging.2015.11.012

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

118-126

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(15)00579-5

journal_volume

38

pub_type

杂志文章

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