3-D reconstruction of the cholinergic basal forebrain system in young and aged rats.

abstract：:We have shown previously that the TG-3 and MPM-2 antibodies recognize phosphoepitopes common to mitosis and degenerating neurons of Alzheimer's disease(AD) brain. Here, we have evaluated their occurrence in human brain biopsy tissue, and confirm that they are absent in mature neurons of adult brain, but reappear durin...

journal_title：Neurobiology of aging

authors： Vincent I,Zheng JH,Dickson DW,Kress Y,Davies P

更新日期：1998-07-01 00:00:00

abstract：:The impact of many inflammatory diseases is influenced by age-related changes in the activation of resident and circulating myeloid cells. In the eye, a major sight-threatening consequence of age-related macular degeneration is the development of severe choroidal neovascularization (CNV). To identify the molecular pat...

journal_title：Neurobiology of aging

authors： Robbie SJ,Georgiadis A,Barker SE,Duran Y,Smith AJ,Ali RR,Luhmann UFO,Bainbridge JW

更新日期：2016-04-01 00:00:00

abstract：:We report that a peripheral injection of Escherichia coli produces both anterograde and retrograde amnesia in 24 month old, but not 3 month old rats for memories that depend on the hippocampus, that is, memory of context, contextual fear, and place learning. The anterograde effect was restricted to measures of long-te...

journal_title：Neurobiology of aging

authors： Barrientos RM,Higgins EA,Biedenkapp JC,Sprunger DB,Wright-Hardesty KJ,Watkins LR,Rudy JW,Maier SF

更新日期：2006-05-01 00:00:00

abstract：:In the present study, we aim at investigating whether education modulates dynamical properties of time-varying whole-brain network connectivity (the chronnectome) in frontotemporal dementia (FTD) at a given level of symptom severity. Dynamic connectivity parameters were evaluated in 128 patients with FTD using indepen...

journal_title：Neurobiology of aging

authors： Premi E,Cristillo V,Gazzina S,Benussi A,Alberici A,Cotelli MS,Calhoun VD,Iraji A,Magoni M,Cotelli M,Micheli A,Gasparotti R,Padovani A,Borroni B

更新日期：2020-09-01 00:00:00

abstract：:GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinica...

journal_title：Neurobiology of aging

authors： Sellami L,Rucheton B,Ben Younes I,Camuzat A,Saracino D,Rinaldi D,Epelbaum S,Azuar C,Levy R,Auriacombe S,Hannequin D,Pariente J,Barbier M,Boutoleau-Bretonnière C,Couratier P,Pasquier F,Deramecourt V,Sauvée M,Sarazin M

更新日期：2020-07-01 00:00:00

abstract：:Dopaminergic neurons in the substantia nigra produce dopamine for the nigrostriatal pathway that facilitates motor function. Postmortem examinations demonstrate an age-related loss of cells in the substantia nigra, with most of the cell loss focused on the dorsal substantia nigra compared with the ventral substantia n...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Spraker MB,Prodoehl J,Zhou XJ,Little DM

更新日期：2012-01-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Robust physiological circadian rhythms form an integral part of well-being. The aging process has been found to negatively impact systems that drive circadian physiology, typically manifesting as symptoms associated with abnormal/disrupted sleeping patterns. Here, we investigated the age-related decline in light-drive...

journal_title：Neurobiology of aging

authors： Biello SM,Bonsall DR,Atkinson LA,Molyneux PC,Harrington ME,Lall GS

更新日期：2018-06-01 00:00:00

abstract：:Lipsitz and Goldberger proposed that there is a loss in the complexity of physiological and behavioral systems with aging and disease. Here, we show that this unidirectional view of the change in system complexity is too narrow in its consideration of the actual changes that occur with aging and disease. An increase o...

journal_title：Neurobiology of aging

authors： Vaillancourt DE,Newell KM

更新日期：2002-01-01 00:00:00

abstract：:Progranulin plays an important role in neuroinflammation in Alzheimer's disease (AD) pathophysiology, being upregulated by activated microglia. This study assessed whether cerebrospinal fluid levels of progranulin correlated with structural neuroimaging measures and cognition in 122 cognitively normal individuals, 81 ...

journal_title：Neurobiology of aging

authors： Batzu L,Westman E,Pereira JB,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2020-04-01 00:00:00

abstract：:We previously established a single-neuron culture system to analyze the primary effects of neurotrophic factors and reported that NGF promoted neurite extension in young adult (4- to 6-month-old) rat dorsal root ganglion (DRG) neurons by promoting neurite arborization. In this study, we demonstrated that the effects o...

journal_title：Neurobiology of aging

authors： Itoh T,Sobue G,Yasuda T,Kimata K,Mitsuma T,Takahashi A

更新日期：1993-03-01 00:00:00

abstract：:Aged rats were chronically administered acetyl-L-carnitine (AC) for 10 months. During this period they were tested on learning and sensorimotor tasks and were then subsequently tested electrophysiologically to assess induction and decay rates of long-term synaptic enhancement (LTE) in the hippocampus. Four groups were...

journal_title：Neurobiology of aging

authors： Davis S,Markowska AL,Wenk GL,Barnes CA

更新日期：1993-01-01 00:00:00

abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

journal_title：Neurobiology of aging

authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

更新日期：2001-01-01 00:00:00

abstract：:Aged rats exhibit an impaired ability to sustain long-term potentiation in dentate gyrus which correlates with a decrease in arachidonic acid concentration. Here we confirm the previous finding that dietary supplementation with arachidonic acid and its precursor, gamma-linolenic acid, reversed the impairment in LTP in...

journal_title：Neurobiology of aging

authors： McGahon BM,Murray CA,Horrobin DF,Lynch

更新日期：1999-11-01 00:00:00

abstract：:In Alzheimer's disease, there is a major redistribution of the tau protein pool from soluble to PHF-bound forms. PHF-bound tau can be distinguished from normal tau by acid reversible occlusion of a generic tau epitope in the tandem repeat region and characteristic sedimentation in the if-II protocol developed in this ...

journal_title：Neurobiology of aging

authors： Wischik CM,Edwards PC,Lai RY,Gertz HN,Xuereb JH,Paykel ES,Brayne C,Huppert FA,Mukaetova-Ladinska EB,Mena R

更新日期：1995-05-01 00:00:00

abstract：:Mutations in Leucine-rich repeat kinase 2 (LRRK2) are recognized as the most frequent genetic factors contributing to Parkinson's disease (PD). The aim of our study was to explore LRRK2 variants in PD patients within the mainland Han Chinese population. The whole coding regions of LRRK2 from 296 PD patients were seque...

journal_title：Neurobiology of aging

authors： Zhang JR,Jin H,Li K,Mao CJ,Yang YP,Wang F,Gu CC,Zhang HJ,Chen J,Liu CF

更新日期：2018-12-01 00:00:00

abstract：:Activated microglia are instrumental to neurodegeneration in Parkinson's disease (PD). Fractalkine, as an exclusive ligand for CX3CR1 expressed on microglia, has recently been reported to be released out by neurons, and induce microglial activation as a neuron-to-glia signal in the spinal cord. However, the role of fr...

journal_title：Neurobiology of aging

authors： Shan S,Hong-Min T,Yi F,Jun-Peng G,Yue F,Yan-Hong T,Yun-Ke Y,Wen-Wei L,Xiang-Yu W,Jun M,Guo-Hua W,Ya-Ling H,Hua-Wei L,Ding-Fang C

更新日期：2011-03-01 00:00:00

abstract：:This study investigated the role of genetic and environmental influences on individual differences in brain volumes measured at 2 time points in normal elderly males from the National Heart, Lung, and Blood Institute Twin Study. The magnetic resonance imaging (MRI) scans were conducted 4 years apart on 33 monozygotic ...

journal_title：Neurobiology of aging

authors： Lessov-Schlaggar CN,Hardin J,DeCarli C,Krasnow RE,Reed T,Wolf PA,Swan GE,Carmelli D

更新日期：2012-04-01 00:00:00

abstract：:We identified and validated several novel inflammatory markers of cognitive performance in community-living older persons. An exploratory study (n = 83) correlated 177 inflammatory markers assayed by Luminex with the Mini-Mental State Examination (MMSE) and identified 8 inflammatory markers for enzyme-linked immunosor...

journal_title：Neurobiology of aging

authors： Gao Q,Camous X,Lu YX,Lim ML,Larbi A,Ng TP

更新日期：2016-03-01 00:00:00

abstract：:In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can i...

journal_title：Neurobiology of aging

authors： Wessel JR,Ullsperger M,Obrig H,Villringer A,Quinque E,Schroeter ML,Bretschneider KJ,Arelin K,Roggenhofer E,Frisch S,Klein TA

更新日期：2016-02-01 00:00:00

abstract：:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common causes of dementia. We compared the regional metabolism on 18F-fluorodeoxyglucose positron emission tomography (PET) among 21 control subjects and cognitively impaired patients due to DLB (N = 63) and AD (N = 38). All participants under...

journal_title：Neurobiology of aging

authors： Ye BS,Lee S,Yoo H,Chung SJ,Lee YH,Choi Y,Lee PH,Sohn YH,Yun M

更新日期：2020-03-01 00:00:00

abstract：:Aged, cognitively-impaired rats (and humans) show hypothalamic-pituitary-adrenal (HPA) hyperactivity that correlates with hippocampal damage. The resultant increase in plasma glucocorticoid exposure is thought to contribute to impaired hippocampal function and to potentiate hippocampal neuron death. In young, adult ra...

journal_title：Neurobiology of aging

authors： Rowe W,Steverman A,Walker M,Sharma S,Barden N,Seckl JR,Meaney MJ

更新日期：1997-09-01 00:00:00

abstract：:The senescence-accelerated mouse (SAMP8) strain exhibits decreased learning and memory and increased amyloid beta (Aβ) peptide accumulation at 12 months. To detect differences in gene expression in SAMP8 mice, we used a control mouse that was a 50% cross between SAMP8 and CD-1 mice and which showed no memory deficits ...

journal_title：Neurobiology of aging

authors： Armbrecht HJ,Siddiqui AM,Green M,Farr SA,Kumar VB,Banks WA,Patrick P,Shah GN,Morley JE

更新日期：2014-01-01 00:00:00

abstract：:Age-related brain changes are widely documented. Because of differences in measurement methods and case selection, the reported effects of age on regional grey and white matter brain volumes, however, are much more pronounced and widespread in neuroimaging than in postmortem studies. Consequently, the magnitude of the...

journal_title：Neurobiology of aging

authors： Piguet O,Double KL,Kril JJ,Harasty J,Macdonald V,McRitchie DA,Halliday GM

更新日期：2009-08-01 00:00:00

abstract：:Amyloid beta (A beta) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human A beta induces humoral immunity, however, the immune response to endogenous rodent A beta is unknown. Fourteen-month J20 APP-tg mice and non-tg littermates were immunized subcutaneously followed by chronic intranasal ...

journal_title：Neurobiology of aging

authors： Seabrook TJ,Bloom JK,Iglesias M,Spooner ET,Walsh DM,Lemere CA

更新日期：2004-10-01 00:00:00

abstract：:Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand...

journal_title：Neurobiology of aging

authors： Bradburn S,McPhee J,Bagley L,Carroll M,Slevin M,Al-Shanti N,Barnouin Y,Hogrel JY,Pääsuke M,Gapeyeva H,Maier A,Sipilä S,Narici M,Robinson A,Mann D,Payton A,Pendleton N,Butler-Browne G,Murgatroyd C

更新日期：2018-03-01 00:00:00

abstract：:Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer's disease patients and mouse models display age-related or amyloid-β peptide (Aβ)-induced reductions in CD200. The goal of this study was to dete...

journal_title：Neurobiology of aging

authors： Varnum MM,Kiyota T,Ingraham KL,Ikezu S,Ikezu T

更新日期：2015-11-01 00:00:00

abstract：:Energy deficiency and dysfunction of the Na,K-ATPase are common consequences of many pathological insults. Glutamate through cyclic GMP and cyclic GMP-dependent protein kinase (PKG) has been shown to stimulate alpha(2/3)-Na,K-ATPase activity in the central nervous system. Thus, a slight impairment of this pathway may ...

journal_title：Neurobiology of aging

authors： Scavone C,Munhoz CD,Kawamoto EM,Glezer I,de Sá Lima L,Marcourakis T,Markus RP

更新日期：2005-06-01 00:00:00

abstract：:Despite very numerous studies on Alzheimer's disease (AD), especially on amyloid plaques and neurofibrillary tangles, little information has been obtained thus on the causes of the disease. Evidence is described here that implicates firstly herpes simplex virus type 1 (HSV1) as a strong risk factor when it is present ...

journal_title：Neurobiology of aging

authors： Itzhaki RF,Wozniak MA,Appelt DM,Balin BJ

更新日期：2004-05-01 00:00:00

abstract：:We obtained serum samples and measured alpha 1-antichymotrypsin (ACT) levels in 36 pairs of consecutive probable Alzheimer's disease (AD) patients and age- and sex-matched, cognitively intact control subjects. Serum ACT was measured by radial immunodiffusion. Unique to this study, we found that ACT levels rose signifi...

journal_title：Neurobiology of aging

authors： Hinds TR,Kukull WA,Van Belle G,Schellenberg GD,Villacres EC,Larson EB

更新日期：1994-01-01 00:00:00