当前位置： SCI文献检索 > NEUROBIOLOGY OF AGING期刊下所有文献 > Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.

Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.

Abstract：

:GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinical phenotype, or disease progression in 160 GRN carriers. Importantly, progranulin levels were influenced by gender, with lower levels in male than in female patients in our study. Although we found no correlation with age at onset or with clinical phenotype, we confirmed that decreased level predicts GRN mutations, even in presymptomatic carriers more than four decades before disease onset. We also provided first evidence for the stability of levels throughout longitudinal trajectory in carriers, over a 4-year time span. Finally, we confirmed that progranulin levels constitute a reliable, cost-effective marker, suitable as a screening tool in patients with familial frontotemporal degeneration, and more broadly in patients without family history or with atypical presentations who are less likely to be referred for molecular diagnosis.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Sellami L,Rucheton B,Ben Younes I,Camuzat A,Saracino D,Rinaldi D,Epelbaum S,Azuar C,Levy R,Auriacombe S,Hannequin D,Pariente J,Barbier M,Boutoleau-Bretonnière C,Couratier P,Pasquier F,Deramecourt V,Sauvée M,Sarazin M

doi

10.1016/j.neurobiolaging.2020.02.014

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

167.e1-167.e9

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(20)30047-6

journal_volume

91

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF AGING文献大全
  • Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old.

    abstract：:Recently, two large, and independent genome wide association studies of late-onset Alzheimer's disease (AD) established association with the same rs11136000 variation in the clusterin (CLU) gene. In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.07.016

    authors： Mengel-From J,Christensen K,McGue M,Christiansen L

    更新日期：2011-03-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide protects against β-amyloid toxicity.

    abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/TauP301L) brains. We established an in vitro model of primary neurona...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.03.022

    authors： Han P,Tang Z,Yin J,Maalouf M,Beach TG,Reiman EM,Shi J

    更新日期：2014-09-01 00:00:00

  • Sleep-disordered breathing in healthy and spousally bereaved elderly: a one-year follow-up study.

    abstract：:This study examined the progression of sleep-disordered breathing (SDB) over 1 year in two samples of elderly subjects: 45 healthy controls (20 men; 25 women mean age 74.8 years) and 27 recently spousally bereaved elders (9 men; 18 women, mean age 69.7 years). Although controls and bereaved subjects did not differ in ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(92)90098-i

    authors： Hoch CC,Reynolds CF 3rd,Buysse DJ,Machen M,Schlernitzauer M,Hall F,Kupfer DJ

    更新日期：1992-11-01 00:00:00

  • Pomegranate peel extract attenuates D-galactose-induced oxidative stress and hearing loss by regulating PNUTS/PP1 activity in the mouse cochlea.

    abstract：:Oxidative stress is considered to be a major contributor to age-related hearing loss (ARHL). Here, we investigated whether pomegranate peel extract (PPE) protected against hearing loss by decreased oxidative stress in the cochlea of D-galactose-induced accelerated aging mice. The aging mice exhibited an increase in he...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.07.007

    authors： Liu S,Xu T,Wu X,Lin Y,Bao D,Di Y,Ma T,Dang Y,Jia P,Xian J,Wang A,Liu Y

    更新日期：2017-11-01 00:00:00

  • Medial septal beta-amyloid 1-40 injections alter septo-hippocampal anatomy and function.

    abstract：:Degeneration of septal neurons in Alzheimer's disease (AD) results in abnormal information processing at cortical circuits and consequent brain dysfunction. The septum modulates the activity of hippocampal and cortical circuits and is crucial to the initiation and occurrence of oscillatory activities such as the hippo...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2008.05.006

    authors： Colom LV,Castañeda MT,Bañuelos C,Puras G,García-Hernández A,Hernandez S,Mounsey S,Benavidez J,Lehker C

    更新日期：2010-01-01 00:00:00

  • Using next-generation sequencing as a genetic diagnostic tool in rare autosomal recessive neurologic Mendelian disorders.

    abstract：:Next-generation sequencing was used to investigate 9 rare Chinese pedigrees with rare autosomal recessive neurologic Mendelian disorders. Five probands with ataxia-telangectasia and 1 proband with chorea-acanthocytosis were analyzed by targeted gene sequencing. Whole-exome sequencing was used to investigate 3 affected...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2013.04.029

    authors： Chen Z,Wang JL,Tang BS,Sun ZF,Shi YT,Shen L,Lei LF,Wei XM,Xiao JJ,Hu ZM,Pan Q,Xia K,Zhang QY,Dai MZ,Liu Y,Ashizawa T,Jiang H

    更新日期：2013-10-01 00:00:00

  • Modeling the relation between neurofibrillary tangles and intellectual status.

    abstract：:The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied in 27 patients over the age of 75. The presence and density of tau positive tangles were assessed in six areas including limbic, paralimbic, and isocortical cortices. In the i...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)80306-5

    authors： Duyckaerts C,Bennecib M,Grignon Y,Uchihara T,He Y,Piette F,Hauw JJ

    更新日期：1997-05-01 00:00:00

  • In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography.

    abstract：:Positron emission tomography (PET) has been used extensively to evaluate the neuropathology of Alzheimer's disease (AD) in vivo. Radiotracers directed toward the amyloid deposition such as [(18)F]-FDDNP (2-(1-{6-[(2-[F]Fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile) and [(11)C]-PIB (Pittsburg compound ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.12.027

    authors： Rojas S,Herance JR,Gispert JD,Abad S,Torrent E,Jiménez X,Pareto D,Perpiña U,Sarroca S,Rodríguez E,Ortega-Aznar A,Sanfeliu C

    更新日期：2013-07-01 00:00:00

  • Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease.

    abstract：:In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD), plasma levels of water-soluble (Vitamin C and uric acid) and of lipophilic (Vitamin A, Vitamin E and carotenoids inc...

    journal_title：Neurobiology of aging

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0197-4580(03)00031-9

    authors： Rinaldi P,Polidori MC,Metastasio A,Mariani E,Mattioli P,Cherubini A,Catani M,Cecchetti R,Senin U,Mecocci P

    更新日期：2003-11-01 00:00:00

  • Regional patterns of gray matter volume, hypometabolism, and beta-amyloid in groups at risk of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD) is characterized by the presence of β-amyloid (Aβ) deposition and neurodegeneration. To seek for signs of such pathologies, we compared regional biomarker degrees and patterns of Aβ deposition, glucose hypometabolism, and gray matter volume (GMV) reduction in 3 groups at risk of AD. In elderly...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.10.023

    authors： Wirth M,Bejanin A,La Joie R,Arenaza-Urquijo EM,Gonneaud J,Landeau B,Perrotin A,Mézenge F,de La Sayette V,Desgranges B,Chételat G

    更新日期：2018-03-01 00:00:00

  • Autophagy meets fused in sarcoma-positive stress granules.

    abstract：:Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures known as stress granules under various stress conditions. In addition, mutant FUS expression can ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.08.019

    authors： Matus S,Bosco DA,Hetz C

    更新日期：2014-12-01 00:00:00

  • Drug abuse and depression: possible models for geriatric anorexia.

    abstract：:The central biochemical pathology of anorexia and the natural aging of the brain is similar. Biochemical models for drug withdrawal and depression may also assist in understanding geriatric anorexia. Norepinephrine, corticotropin releasing factor and beta-endorphin may key neurotransmitters in all of these conditions....

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(88)80010-1

    authors： Giannini AJ

    更新日期：1988-01-01 00:00:00

  • Longitudinal study of basal cortisol levels in healthy elderly subjects: evidence for subgroups.

    abstract：:A group of 51 healthy elderly volunteer subjects participated in a 3- to 6-year longitudinal study of basal cortisol levels. Once per year basal cortisol levels were examined using hourly sampling over a 24-h period. Analyses of three cortisol measures (last measure obtained, mean cortisol levels across years, and the...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(95)02005-5

    authors： Lupien S,Lecours AR,Schwartz G,Sharma S,Hauger RL,Meaney MJ,Nair NP

    更新日期：1996-01-01 00:00:00

  • The hormone therapy, Premarin, impairs hippocampus-dependent spatial learning and memory and reduces activation of new granule neurons in response to memory in female rats.

    abstract：:Estrogens have been implicated as possible therapeutic agents for improving cognition in postmenopausal women and have been linked to neurodegenerative disorders such as Alzheimer's disease. However, the utility of Premarin (Wyeth Pharmaceuticals, Markham, ON, Canada), a conjugated equine estrogen and the most commonl...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2012.07.009

    authors： Barha CK,Galea LA

    更新日期：2013-03-01 00:00:00

  • Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease.

    abstract：:Discovered in the brains of multiple animal species, piRNAs may contribute to the pathogenesis of neuropsychiatric illnesses. The present study aimed to identify brain piRNAs across transcriptome that are associated with Alzheimer's disease (AD). Prefrontal cortical tissues of 6 AD cases and 6 controls were examined f...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.05.020

    authors： Qiu W,Guo X,Lin X,Yang Q,Zhang W,Zhang Y,Zuo L,Zhu Y,Li CR,Ma C,Luo X

    更新日期：2017-09-01 00:00:00

  • Spatial relationships between astrocytes and classical plaque components.

    abstract：:Four biopsies of the brain cortex of patients with Alzheimer's disease were used for ultrastructural studies. Three-dimensional reconstruction and morphometric studies of three classical plaques were carried out to determine the distribution of the astrocytes and their processes, and spatial relationships between astr...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(91)90091-w

    authors： Wisniewski HM,Wegiel J

    更新日期：1991-09-01 00:00:00

  • Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse.

    abstract：:Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. Several healthy lifestyle options and over-the-counter drugs that it has been suggested delay the onset of the disease are in an experimental phase, but it is unclear whether they will have any therap...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2011.11.016

    authors： García-Mesa Y,Giménez-Llort L,López LC,Venegas C,Cristòfol R,Escames G,Acuña-Castroviejo D,Sanfeliu C

    更新日期：2012-06-01 00:00:00

  • Genetic analysis of NUS1 in Chinese patients with Parkinson's disease.

    abstract：:Recently, a mutation in NUS1 has been reported to be associated with Parkinson's disease (PD) in a Chinese population. To further investigate the relationship between NUS1 and sporadic PD, we sequenced all exons and exon-intron boundaries of NUS1 in Chinese Han population including 494 PD patients and 478 healthy cont...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2019.09.002

    authors： Chen X,Xiao Y,Zhou M,Lin Y,Guo W,Huang S,Qiu J,Peng G,Mo M,Li Z,Zhu X,Xu P

    更新日期：2020-02-01 00:00:00

  • Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases.

    abstract：:Lipid rafts are highly dynamic membrane microdomains intimately associated with cell signaling. Compelling evidence has demonstrated that alterations in lipid rafts are associated with neurodegenerative diseases such Alzheimer's disease, but at present, whether alterations in lipid raft microdomains occur in other typ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2016.08.027

    authors： Marin R,Fabelo N,Martín V,Garcia-Esparcia P,Ferrer I,Quinto-Alemany D,Díaz M

    更新日期：2017-01-01 00:00:00

  • Mutation analysis of patients with neurodegenerative disorders using NeuroX array.

    abstract：:Genetic analyses of patients with neurodegenerative disorders have identified multiple genes that need to be investigated for the presence of damaging variants. However, mutation analysis by Sanger sequencing is costly and time consuming. We tested the utility of a recently designed semi-custom genome-wide array (Neur...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.07.038

    authors： Ghani M,Lang AE,Zinman L,Nacmias B,Sorbi S,Bessi V,Tedde A,Tartaglia MC,Surace EI,Sato C,Moreno D,Xi Z,Hung R,Nalls MA,Singleton A,St George-Hyslop P,Rogaeva E

    更新日期：2015-01-01 00:00:00

  • Longitudinal assessment of default-mode brain function in aging.

    abstract：:Age-related changes in the default-mode network (DMN) have been identified in prior cross-sectional functional magnetic resonance imaging studies. Here, we investigated longitudinal change in DMN activity and connectivity. Cognitively intact participants (aged 49-79 years at baseline) were scanned twice, with a 6-year...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2014.03.012

    authors： Persson J,Pudas S,Nilsson LG,Nyberg L

    更新日期：2014-09-01 00:00:00

  • Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.

    abstract：:Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been foun...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2017.01.019

    authors： Siitonen A,Nalls MA,Hernández D,Gibbs JR,Ding J,Ylikotila P,Edsall C,Singleton A,Majamaa K

    更新日期：2017-05-01 00:00:00

  • Age-related decrease in sympathetic sprouting is primarily due to decreased target receptivity: implications for understanding brain aging.

    abstract：:Aging of the nervous system is characterized by reduced anatomical plasticity. The cause of this decreased plasticity is not known because it is usually not possible to distinguish between extrinsic and intrinsic factors that affect neuronal growth. One example of age-related reduced neuronal plasticity that is amenda...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/0197-4580(90)90543-9

    authors： Crutcher KA

    更新日期：1990-05-01 00:00:00

  • Sex differences in risk factors for white matter hyperintensities in non-demented older individuals.

    abstract：:White matter hyperintensities (WMH) are generally considered to be associated with cerebral small vessel disease, especially, in older age. Although significant sex differences have been reported in the severity of WMH, it is not yet known if the risk factors for WMH differ in men and women. In this study, magnetic re...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2020.11.001

    authors： Alqarni A,Jiang J,Crawford JD,Koch F,Brodaty H,Sachdev P,Wen W

    更新日期：2020-11-10 00:00:00

  • Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

    abstract：:4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD), we quantified levels of free and protein-b...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(97)00108-5

    authors： Lovell MA,Ehmann WD,Mattson MP,Markesbery WR

    更新日期：1997-09-01 00:00:00

  • Aging alters envelope representations of speech-like sounds in the inferior colliculus.

    abstract：:Hearing impairment in older people is thought to arise from impaired temporal processing in auditory circuits. We used a systems-level (scalp recordings) and a microcircuit-level (extracellular recordings) approach to investigate how aging affects the sensitivity to temporal envelopes of speech-like sounds in rats. Sc...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2018.08.023

    authors： Parthasarathy A,Herrmann B,Bartlett EL

    更新日期：2019-01-01 00:00:00

  • Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus.

    abstract：:Age-dependent cognitive impairments have been correlated with functional and structural modifications in the hippocampal formation. In particular, the brain endogenous steroid pregnenolone-sulfate (Preg-S) is a cognitive enhancer whose hippocampal levels have been linked physiologically to cognitive performance in sen...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2004.03.013

    authors： Mayo W,Lemaire V,Malaterre J,Rodriguez JJ,Cayre M,Stewart MG,Kharouby M,Rougon G,Le Moal M,Piazza PV,Abrous DN

    更新日期：2005-01-01 00:00:00

  • Age-related effects on eyeblink conditioning in the F344 x BN F1 hybrid rat.

    abstract：:Young, middle-aged, old, and senescent Fischer 344 x Brown Norway F1 hybrid rats were trained in either the trace or delay eyeblink conditioning task in order to investigate how aging affects associative learning and memory over the life span. Senescent rats at 34-35 months showed severe impairments in acquisition of ...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/s0197-4580(00)00194-9

    authors： Knuttinen MG,Gamelli AE,Weiss C,Power JM,Disterhoft JF

    更新日期：2001-01-01 00:00:00

  • Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice.

    abstract：:Glial cell line-derived neurotrophic factor (GDNF) supports the viability of midbrain dopamine (DA) neurons that degenerate in Parkinson's disease. Middle-aged, 12 month old, Gdnf heterozygous (Gdnf(+/-)) mice have diminished spontaneous locomotor activity and enhanced synaptosomal DA uptake compared with wild type mi...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章

    doi：10.1016/j.neurobiolaging.2010.10.013

    authors： Littrell OM,Pomerleau F,Huettl P,Surgener S,McGinty JF,Middaugh LD,Granholm AC,Gerhardt GA,Boger HA

    更新日期：2012-02-01 00:00:00

  • Extracellular vesicles, new actors in the search for biomarkers of dementias.

    abstract：:Increased life expectancy impacts directly on the number of older people worldwide with the associated increase in neurodegenerative diseases. Besides their social implications, the different forms of dementia, including Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies or frontotemporal dementia, sh...

    journal_title：Neurobiology of aging

    pub_type： 杂志文章,评审

    doi：10.1016/j.neurobiolaging.2018.10.006

    authors： Gámez-Valero A,Beyer K,Borràs FE

    更新日期：2019-02-01 00:00:00