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Aging alters envelope representations of speech-like sounds in the inferior colliculus.

Abstract：

:Hearing impairment in older people is thought to arise from impaired temporal processing in auditory circuits. We used a systems-level (scalp recordings) and a microcircuit-level (extracellular recordings) approach to investigate how aging affects the sensitivity to temporal envelopes of speech-like sounds in rats. Scalp-recorded potentials suggest an age-related increase in sensitivity to temporal regularity along the ascending auditory pathway. The underlying cellular changes in the midbrain were examined using extracellular recordings from inferior colliculus neurons. We observed an age-related increase in sensitivity to the sound's onset and temporal regularity (i.e., periodicity envelope) in the spiking output of inferior colliculus neurons, relative to their synaptic inputs (local field potentials). This relative enhancement for aged animals was most prominent for multi-unit (relative to single-unit) spiking activity. Spontaneous multi-unit, but not single-unit, activity was also enhanced in aged compared with young animals. Our results suggest that aging is associated with altered sensitivity to a sound's temporal regularities, and that these effects may be due to increased gain of neural network activity in the midbrain.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Parthasarathy A,Herrmann B,Bartlett EL

doi

10.1016/j.neurobiolaging.2018.08.023

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

30-40

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(18)30314-2

journal_volume

73

pub_type

杂志文章

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