Abstract:
:A group of 51 healthy elderly volunteer subjects participated in a 3- to 6-year longitudinal study of basal cortisol levels. Once per year basal cortisol levels were examined using hourly sampling over a 24-h period. Analyses of three cortisol measures (last measure obtained, mean cortisol levels across years, and the cortisol slope) revealed that the slope of the regression line measuring cortisol levels at each year was the most predictive measure of cortisol secretion over the years in this elderly population. Cortisol levels were shown to increase with years in one subgroup, to decrease in another, and to remain stable in a third. The age of the subjects was not related to either cortisol levels or to the pattern of change in cortisol secretion over years. Free and total cortisol levels were highly correlated and the groups did not differ with regard to plasma corticosteroid binding globulin. No group differences were observed for weight, height, body mass index, pulse, blood pressure and glucose. However, significant group differences were reported for plasma triglycerides levels as well as high density lipoproteins levels. Positive correlations were reported between the obsession/compulsion subscale of the SCL-90 questionnaire and the cortisol slope of subjects. Finally, previously reported group differences in neuropsychological performance are summarized. Thus, there exists considerable variation in hypothalamo-pituitary-adrenal function amongst aged humans. These results are consistent with recent animal studies showing the existence of subpopulations of aged rats which differ in hypothalamo-pituitary-adrenal activity and cognitive efficiency.
journal_name
Neurobiol Agingjournal_title
Neurobiology of agingauthors
Lupien S,Lecours AR,Schwartz G,Sharma S,Hauger RL,Meaney MJ,Nair NPdoi
10.1016/0197-4580(95)02005-5subject
Has Abstractpub_date
1996-01-01 00:00:00pages
95-105issue
1eissn
0197-4580issn
1558-1497pii
0197458095020055journal_volume
17pub_type
杂志文章abstract::Prenatal ethanol exposure produces severe changes in brain, liver, and kidney through mechanisms involving growth factors. These molecules regulate survival, differentiation, maintenance, and connectivity of brain, liver, and kidney cells. Despite the abundant available data on the short and mid-lasting effects of eth...
journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 临床试验,杂志文章
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更新日期:2005-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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更新日期:1999-01-01 00:00:00
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journal_title:Neurobiology of aging
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更新日期:2019-12-01 00:00:00
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journal_title:Neurobiology of aging
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更新日期:1993-05-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/s0197-4580(96)00179-0
更新日期:1996-11-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章,评审
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2015.09.023
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journal_title:Neurobiology of aging
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2015.01.013
更新日期:2015-04-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2006.07.009
更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.neurobiolaging.2011.11.006
更新日期:2012-06-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:1981-04-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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journal_title:Neurobiology of aging
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00