Distinguishing between dementia with Lewy bodies and Alzheimer's disease using metabolic patterns.

Abstract:

:Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common causes of dementia. We compared the regional metabolism on 18F-fluorodeoxyglucose positron emission tomography (PET) among 21 control subjects and cognitively impaired patients due to DLB (N = 63) and AD (N = 38). All participants underwent 18F-Florbetaben (FBB) PET, and all DLB patients had abnormality on dopamine transporter PET. Both the FBB-positive DLB (N = 38) and FBB-negative DLB (N = 25) groups had increased metabolism in the bilateral central cerebellum, posterior putamen, and somatomotor cortices compared with the control and AD groups. Compared with the control group, the DLB and AD groups commonly exhibited hypometabolism in the bilateral lateral temporal, temporo-parietal junction, posterior cingulate, and precuneus cortices. Both DLB groups had additional hypometabolism in the bilateral thalami and dorsolateral prefrontal cortices, whereas the AD group did in the bilateral entorhinal cortices and hippocampi. Our results suggest that hypermetabolism in the somatomotor cortex, posterior putamen, or central cerebellum could be a useful imaging biomarker for detecting DLB patients, while entorhinal/hippocampal hypometabolism could be a specific biomarker for AD.

journal_name

Neurobiol Aging

journal_title

Neurobiology of aging

authors

Ye BS,Lee S,Yoo H,Chung SJ,Lee YH,Choi Y,Lee PH,Sohn YH,Yun M

doi

10.1016/j.neurobiolaging.2019.10.020

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

11-17

eissn

0197-4580

issn

1558-1497

pii

S0197-4580(19)30384-7

journal_volume

87

pub_type

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