Geometric response to nerve growth factor is preserved in aged rat sensory neurons: a single-neuron culture study.

abstract：:Dietary restriction (DR) extends lifespan in diverse organisms and, in animal and cellular models, can delay a range of aging-related diseases including Alzheimer's disease (AD). A better understanding of the mechanisms mediating these interactions, however, may reveal novel pathways involved in AD pathogenesis, and p...

journal_title：Neurobiology of aging

authors： Kerr F,Augustin H,Piper MD,Gandy C,Allen MJ,Lovestone S,Partridge L

更新日期：2011-11-01 00:00:00

abstract：:The supraoptic nucleus of the F344 rat shows an age-related dendritic regression. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a qu...

journal_title：Neurobiology of aging

authors： Kaplan AS,Gash DM,Flood DG,Coleman PD

更新日期：1985-10-01 00:00:00

abstract：:C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansio...

journal_title：Neurobiology of aging

authors： Kun-Rodrigues C,Ross OA,Orme T,Shepherd C,Parkkinen L,Darwent L,Hernandez D,Ansorge O,Clark LN,Honig LS,Marder K,Lemstra A,Scheltens P,van der Flier W,Louwersheimer E,Holstege H,Rogaeva E,St George-Hyslop P,Londos E,

更新日期：2017-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are adult-onset neurodegenerative diseases with overlapping clinical characteristics. They share common genetic causes and pathologic hallmarks such as TDP-43 neuronal accumulations. Recently, exome analysis identified mutations in matrin...

journal_title：Neurobiology of aging

authors： Millecamps S,De Septenville A,Teyssou E,Daniau M,Camuzat A,Albert M,LeGuern E,Galimberti D,French research network on FTD and FTD-ALS.,Brice A,Marie Y,Le Ber I

更新日期：2014-12-01 00:00:00

abstract：:The application of beta-amyloid (Abeta) is cytotoxic to endothelial cells, promotes vasoconstriction and impairs nitric oxide (NO) generation or action. However, there is no information on the effect of intracellular Abeta on endothelial cell biology, although recent studies indicate that neuronal Abeta drives Alzheim...

journal_title：Neurobiology of aging

authors： Suhara T,Magrané J,Rosen K,Christensen R,Kim HS,Zheng B,McPhie DL,Walsh K,Querfurth H

更新日期：2003-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a uniquely human brain disorder characterized by the accumulation of amyloid-beta protein (Aβ) into extracellular plaques, neurofibrillary tangles (NFT) made from intracellular, abnormally phosphorylated tau, and selective neuronal loss. We analyzed a large group of aged chimpanzees (n = 20...

journal_title：Neurobiology of aging

authors： Edler MK,Sherwood CC,Meindl RS,Hopkins WD,Ely JJ,Erwin JM,Mufson EJ,Hof PR,Raghanti MA

更新日期：2017-11-01 00:00:00

abstract：:Calmodulin (CaM) and tubulin were analyzed by radioimmunoassay in subcellular fractions prepared from cerebral cortex and striatum of aging male C57BL/6J mice. Three fractions were prepared by a new procedure: cytosol (soluble); EGTA-releasable, membrane-bound; and detergent-extractable (Triton X-100), membrane-bound ...

journal_title：Neurobiology of aging

authors： May PC,Severson JA,Osterburg HH,Finch CE

更新日期：1987-03-01 00:00:00

abstract：:The study aimed to evaluate the effects of noninvasive brain stimulation on cognitive function in healthy older adults and patients with Alzheimer's disease. A comprehensive literature search was performed on noninvasive stimulation studies published from January 1990 to November 2014 in Pubmed and Web of Science. Fou...

journal_title：Neurobiology of aging

authors： Hsu WY,Ku Y,Zanto TP,Gazzaley A

更新日期：2015-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by an extensive loss of motor neurons in the primary motor cortex, brainstem, and spinal cord. Genetic studies report a high heritability of ALS. Recently, whole-exome sequencing analysis of familial ALS (FALS) patients allow...

journal_title：Neurobiology of aging

authors： Leblond CS,Gan-Or Z,Spiegelman D,Laurent SB,Szuto A,Hodgkinson A,Dionne-Laporte A,Provencher P,de Carvalho M,Orrù S,Brunet D,Bouchard JP,Awadalla P,Dupré N,Dion PA,Rouleau GA

更新日期：2016-01-01 00:00:00

abstract：:We have measured several morphological parameters by electron microscopy of the frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rats 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase i...

journal_title：Neurobiology of aging

authors： Hicks P,Rolsten C,Brizzee D,Samorajski T

更新日期：1983-04-01 00:00:00

abstract：:Amyloid deposits are one of the hallmarks of Alzheimer's disease. Recent studies, in transgenic mice modeling Alzheimer's disease showed that, using in vivo, contrast agent-free, MRI, thalamic amyloid plaques are more easily detected than other plaques of the brain. Our study evaluated the characteristics of these tha...

journal_title：Neurobiology of aging

authors： Dhenain M,El Tannir El Tayara N,Wu TD,Guégan M,Volk A,Quintana C,Delatour B

更新日期：2009-01-01 00:00:00

abstract：:Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen rep...

journal_title：Neurobiology of aging

authors： Eberling JL,Wu C,Haan MN,Mungas D,Buonocore M,Jagust WJ

更新日期：2003-09-01 00:00:00

abstract：:Omegaconotoxin binding was studied in young (3 months) and old (24 months) male Sprague-Dawley rats. In both groups omegaconotoxin binding displayed high affinity, was specific and saturable. The age-related changes are mainly a decrease in the Bmax in striatum and cortex (-29% and -31%, respectively). Binding paramet...

journal_title：Neurobiology of aging

authors： Moresco RM,Govoni S,Battaini F,Trivulzio S,Trabucchi M

更新日期：1990-07-01 00:00:00

abstract：:The activities of presenilin 1 (PS1) and 2 modulate the proteolytic processing of amyloid precursor proteins to produce Abeta1-42, and mutations in these proteins are associated with an accelerated rate of Abeta deposition. PS1 and PS2 themselves are subject to a highly-regulated endoproteolytic cleavage to generate s...

journal_title：Neurobiology of aging

authors： Borchelt DR,Lee MK,Gonzales V,Slunt HH,Ratovitski T,Jenkins NA,Copeland NG,Price DL,Sisodia SS

更新日期：2002-03-01 00:00:00

abstract：:We evaluated young (3-4 months) and aged (22-24 months) male Sprague-Dawley rats in an attentional set-shifting procedure that assessed reversal, intradimensional shift (IDS), and extradimensional shift (EDS) discrimination learning tasks within one test session. These aspects of discrimination learning are sensitive ...

journal_title：Neurobiology of aging

authors： Rodefer JS,Nguyen TN

更新日期：2008-02-01 00:00:00

abstract：:It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which is highly expressed in nervous system and regulated by various posttranslational modifications including phosphorylation...

journal_title：Neurobiology of aging

authors： Yan J,Liu XH,Han MZ,Wang YM,Sun XL,Yu N,Li T,Su B,Chen ZY

更新日期：2015-01-01 00:00:00

abstract：:Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer's disease patients and mouse models display age-related or amyloid-β peptide (Aβ)-induced reductions in CD200. The goal of this study was to dete...

journal_title：Neurobiology of aging

authors： Varnum MM,Kiyota T,Ingraham KL,Ikezu S,Ikezu T

更新日期：2015-11-01 00:00:00

abstract：:We have used structural equation models to explicitly distinguish functional status and therefore "dementia-relevant" variance in cognitive task performance (i.e., "δ" for dementia). Our approach is modular and can be directed to other targets. In this analysis, we construct a δ ortholog representing the "cognitive co...

journal_title：Neurobiology of aging

authors： Royall DR,Bishnoi RJ,Palmer RF

更新日期：2015-07-01 00:00:00

abstract：:A recent genome-wide association study of patients with essential tremor (ET) from Germany has nominated SLC1A2 rs3794087 as a novel risk factor for disease. This association was independently replicated in the Chinese population, albeit with an opposite direction of effect. To further define the role of SLC1A2 in ET,...

journal_title：Neurobiology of aging

authors： Ross JP,Rayaprolu S,Bernales CQ,Soto-Ortolaza AI,van Gerpen J,Uitti RJ,Wszolek ZK,Rajput A,Rajput AH,Rajput ML,Ross OA,Vilariño-Güell C

更新日期：2014-04-01 00:00:00

abstract：:Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In c...

journal_title：Neurobiology of aging

authors： Greenwood CE,Tatton WG,Seniuk NA,Biddle FG

更新日期：1991-09-01 00:00:00

abstract：:Calcium-binding proteins play potentially important roles in neurogenesis and neuroprotective mechanism(s). Some evidence exists that brain calbindin-D28K (CALB) is regulated by androgens. In the present study, calretinin (CALRET) and CALB patterns were determined by Western analysis in the medial basal hypothalamus (...

journal_title：Neurobiology of aging

authors： Lephart ED,Taylor H,Jacobson NA,Watson MA

更新日期：1998-05-01 00:00:00

abstract：:RACK1 (receptor for activated C-kinase 1), an anchoring protein that shuttles activated PKC to cellular membranes, plays an important role in PKC-mediated signal transduction pathways. A significant loss of RACK1 has been found in the brain of aging animals and Alzheimer's disease (AD) patients, which implicates the p...

journal_title：Neurobiology of aging

authors： Liu W,Dou F,Feng J,Yan Z

更新日期：2011-10-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution...

journal_title：Neurobiology of aging

authors： Sassi C,Nalls MA,Ridge PG,Gibbs JR,Ding J,Lupton MK,Troakes C,Lunnon K,Al-Sarraj S,Brown KS,Medway C,Clement N,Lord J,Turton J,Bras J,Almeida MR,ARUK Consortium.,Holstege H,Louwersheimer E,van der Flier WM,Schelte

更新日期：2016-10-01 00:00:00

abstract：:We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD wi...

journal_title：Neurobiology of aging

authors： Babiloni C,Del Percio C,Lizio R,Noce G,Lopez S,Soricelli A,Ferri R,Pascarelli MT,Catania V,Nobili F,Arnaldi D,Famà F,Orzi F,Buttinelli C,Giubilei F,Bonanni L,Franciotti R,Onofrj M,Stirpe P,Fuhr P,Gschwandtner U,

更新日期：2019-01-01 00:00:00

abstract：:Regions of diffuse periventricular white matter hyperintensities (PVWMH) are a common finding on T(2)-weighted MRI scans of older subjects, but their aetiology remains unclear. The aim of this study was to characterize differences in water diffusion and magnetization transfer MRI parameters between macroscopically nor...

journal_title：Neurobiology of aging

authors： Bastin ME,Clayden JD,Pattie A,Gerrish IF,Wardlaw JM,Deary IJ

更新日期：2009-01-01 00:00:00

abstract：:Neuroimaging biomarkers differ between patients with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Whether these changes reflect cognitive heterogeneity or differences in disease severity is still unknown. This study aimed at investigating changes in neuroimaging biomarkers, accordi...

journal_title：Neurobiology of aging

authors： Aziz AL,Giusiano B,Joubert S,Duprat L,Didic M,Gueriot C,Koric L,Boucraut J,Felician O,Ranjeva JP,Guedj E,Ceccaldi M

更新日期：2017-06-01 00:00:00

abstract：:Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of neuronal cultures with low concentrations of trypsin, a member of the serine family of proteases, protects neurons from toxic insults by binding to the pro...

journal_title：Neurobiology of aging

authors： Nikolakopoulou AM,Georgakopoulos A,Robakis NK

更新日期：2016-06-01 00:00:00

abstract：:Next-generation sequencing was used to investigate 9 rare Chinese pedigrees with rare autosomal recessive neurologic Mendelian disorders. Five probands with ataxia-telangectasia and 1 proband with chorea-acanthocytosis were analyzed by targeted gene sequencing. Whole-exome sequencing was used to investigate 3 affected...

journal_title：Neurobiology of aging

authors： Chen Z,Wang JL,Tang BS,Sun ZF,Shi YT,Shen L,Lei LF,Wei XM,Xiao JJ,Hu ZM,Pan Q,Xia K,Zhang QY,Dai MZ,Liu Y,Ashizawa T,Jiang H

更新日期：2013-10-01 00:00:00

abstract：:The first hypothesis free genome wide association study on cognition recently revealed the thus far unknown association of a single nucleotide polymorphism (SNP) of the KIBRA gene with episodic memory in healthy young and middle aged volunteers. Here, we report the first independent replication of this finding in an i...

journal_title：Neurobiology of aging

authors： Schaper K,Kolsch H,Popp J,Wagner M,Jessen F

更新日期：2008-07-01 00:00:00

abstract：:Studies in vitro have suggested that acetylcholinesterase (AChE) may interact with beta-amyloid to promote deposition of amyloid plaques in the brain of patients with Alzheimer's disease. To test that hypothesis in vivo, we crossed Tg2576 mice, which express human amyloid precursor protein and develop plaques at 9 mon...

journal_title：Neurobiology of aging

authors： Rees T,Hammond PI,Soreq H,Younkin S,Brimijoin S

更新日期：2003-10-01 00:00:00